Applications of Orthogonal “Click” Chemistries in the Synthesis of Functional Soft Materials

Abstract

in 2006, where he conducted research with Professor Dhandapani Venkataraman of the Chemistry Department and Professor Todd Emrick of the Polymer Science and Engineering Department. He came to UCSB to pursue a Ph.D. in the Hawker group in 2006, where his research is focused on both smallmolecule and polymer synthesis for solar cells and other energy capture and storage applications.

Porous polymer particles—A comprehensive guide to synthesis, characterization, functionalization and applications

“…From the several proposed click type reactions in the literature [326][327], two of them received much attention within the polymer society: Cu(I) catalyzed azide-alkyne cycloaddition (CuAAC) [328][329][330][331][332] and the addition of a thiyl radical to olefins (thiol-ene and thiol-yne) [230,[333][334] (Scheme 2).…”

Chemoenzymatic Synthesis of Polypeptides for Use as Functional and Structural Materials

“…Methyl, [57,58,63] ethyl [46,49,52,56,62] Proteinase I, [49] papain (4)(5)(6)(7)(8)(9)(10)(11)(12), [46,52,[56][57][58][59][60]62] bromelain (6.5-7.9), [46,59] α-chymotrypsin (8.2-9.4), [46,59,61] protease SG (8.5), [59] CPDY (6) [63] l-Isoleucine…”

“…Poly(Glu-co-Cys) is a biomimetic polypeptide of phytochelatins, which effectively capture and remove heavy metals in natural plants. Poly(Glu-co-Cys) with a composition of Glu/Cys = 53/47 exhibited the ability to sequester divalent heavy metal ions, similar to the uniform sequence peptide (Glu-Cys) 4 -Gly, a phytochelatin analog. [106] These results suggest that cysteine-containing polypeptides can be used as a potential sorbent for toxic heavy metals in wastewater and polluted soils.…”

“…The wide range of protein functionality has inspired intense interest in the possibility of using polypeptide materials in various fields, including biomedicine, pharmaceuticals, and tissue engineering. [1][2][3][4][5][6][7] In particular, specific functional motifs of polypeptides, which are represented by short polypeptide fragments in their sequences, are extracted to exploit their specific functions. [3,8] sequentially controlled polypeptides.…”

Click Chemistry‐Based Functionalization on Non‐Oxidized Silicon Substrates

“…[40] The "click" chemistry toolbox includes, for example, ring-opening reactions, thiolene addition, and CuAAC reactions. [41][42][43][44][45] In particular, the CuAAC reaction can be performed under physiological conditions and has found numerous applications in the field of surface chemistry. [45] The upcoming use of silicon-based materials has logically initiated a growing interest in the post-modification of SiÀC-bound organic monolayers by using the click reaction.…”