Self-assembled nanoparticles from thiol functionalized liquid crystalline brush block copolymers for dual encapsulation of doxorubicin and gold nanoparticles

Abstract

A facile approach to synthesize new thiol functionalized liquid crystalline brush block copolymers for dual encapsulation of an anticancer drug and inorganic nanoparticles.

Redox-sensitive nanoparticles from amphiphilic cholesterol-based block copolymers for enhanced tumor intracellular release of doxorubicin

“…By comparing the integration of peaks in the 1 H-NMR spectra at 5.33 ppm (olefin group in cholesteryl moiety) and 3.64 ppm (PEO repeating unit), the weight fraction of the each block was determined. 31 Gel permeation chromatography (GPC) was used to measure the number average molecular (M n ) and the polydispersity indices (PDI) of PEO-SS-PC5MA (Table 1). The PEO-SS-PC5MA sharply shifted to a higher molecular weight region with a narrow molecular weight distribution.…”

“…26-30 Our previous studies have shown that amphiphilic brush block copolymers containing cholesterol blocks formed long circulating self-assembled nanoparticles for improved DOX delivery to tumor. 31, 32 However, these nanoparticles showed a very slow drug release pattern that reduced their anti-tumor effect. 32 …”

Well-defined diblock brush polymer–drug conjugates for sustained delivery of paclitaxel

“…16 With densely grafted macromolecular architectures, brush polymers can possess a variety of well-defined unimolecular nanostructures, as well as intermolecularly assembled superstructures. [22][23][24][25][26][27][28][29] Brush copolymers with amphiphilic poly-(ε-caprolactone)-b-poly(ethylene glycol) (PCL-b-PEG) diblock grafts have been studied for the encapsulation and release of DOX. [22][23][24][25][26][27][28][29] Brush copolymers with amphiphilic poly-(ε-caprolactone)-b-poly(ethylene glycol) (PCL-b-PEG) diblock grafts have been studied for the encapsulation and release of DOX.…”

“…22,23 As reported by Wang and co-workers, 22 these brush copolymers assembled into spherical multi-molecular micelles in aqueous solutions, and these micelles exhibited higher loading and slower release of DOX than the spherical micelles of the corresponding linear PCL 19 -b-PEG 45 diblock copolymer. 24,25 The selfassembled nanostructures of these copolymers were capable of encapsulating a high wt% DOX, and in vivo studies showed that the resulting DOX-loaded nanostructures can lead to improved DOX delivery to tumour tissues as compared to free DOX. Comparison of the results reported by these two groups indicated that the assembly behaviour of brush polymers can critically affect their drug encapsulation and release performance.…”

Brush in the bath of active particles: Anomalous stretching of chains and distribution of particles

“…6,[23][24][25][26][27][28] Theoretical and simulation studies have shown that the solubility, the size and the shape of particles greatly influence their spatial organization on the brush. [29][30][31][32][33][34][35][36][37][38][39][40][41][42] For example, for soluble spherical nanoparticles, there is an upper threshold size beyond which particles cannot penetrate into the brush and a lower threshold size below which particles can completely penetrate into the brush; and for the size in between particles can partly penetrate into the brush with a thickness proportional to the brush height and inversely proportional to the particle volume.…”