Self-assembled nanoparticles composed of glycol chitosan-dequalinium for mitochondria-targeted drug delivery

Mallick, Sudipta; Song, Su Jeong; Bae, Yoonhee; Choi, Ji Soo

doi:10.1016/j.ijbiomac.2019.03.215

Cited by 36 publications

(26 citation statements)

References 35 publications

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“…Covalent modifications of chitosan to aid in its mitochondrial targeting have also been investigated, such as N-glycyrrhetinic acid-PEG-chitosan and N-quaternary ammonium chitosan NQC loaded with brucine, which indicated mitochondrial targeting in HepG2 cells [105]. Triphenyl phosphine-conjugated chitosan NPs, hyaluronic acid-coated chitosan NPs, and glycol chitosan polymerized with dequalinium have all been used; however, in these cases, chitosan was utilized as an aid for efficient cellular uptake, whereas the mitochondrial targeting moieties were triphenyl phosphine, hyaluronic acid, and dequalinium, respectively [106][107][108]. Conversely, carboxymethylated chitosan and chitosan-coated iron oxide NPs have been used to prevent mitochondrial stress and hydrogen peroxide-induced cell death in Schwan cells in addition to mitochondrial membrane protection with reduced ROS generation in HeLa, A549, and HEK 293 cell lines, respectively [109,110].…”

Section: Mitochondrial Metabolismmentioning

confidence: 99%

Chitosan Nanoparticles at the Biological Interface: Implications for Drug Delivery

et al. 2021

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The unique properties of chitosan make it a useful choice for various nanoparticulate drug delivery applications. Although chitosan is biocompatible and enables cellular uptake, its interactions at cellular and systemic levels need to be studied in more depth. This review focuses on the various physical and chemical properties of chitosan that affect its performance in biological systems. We aim to analyze recent research studying interactions of chitosan nanoparticles (NPs) upon their cellular uptake and their journey through the various compartments of the cell. The positive charge of chitosan enables it to efficiently attach to cells, increasing the probability of cellular uptake. Chitosan NPs are taken up by cells via different pathways and escape endosomal degradation due to the proton sponge effect. Furthermore, we have reviewed the interaction of chitosan NPs upon in vivo administration. Chitosan NPs are immediately surrounded by a serum protein corona in systemic circulation upon intravenous administration, and their biodistribution is mainly to the liver and spleen indicating RES uptake. However, the evasion of RES system as well as the targeting ability and bioavailability of chitosan NPs can be improved by utilizing specific routes of administration and covalent modifications of surface properties. Ongoing clinical trials of chitosan formulations for therapeutic applications are paving the way for the introduction of chitosan into the pharmaceutical market and for their toxicological evaluation. Chitosan provides specific biophysical properties for effective and tunable cellular uptake and systemic delivery for a wide range of applications.

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Section: Mitochondrial Metabolismmentioning

confidence: 99%

Chitosan Nanoparticles at the Biological Interface: Implications for Drug Delivery

et al. 2021

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“…Clinically, invasive surgery has been performed to deliver drugs locally into the CNS, but it can damage the permeability of the BBB, which may cause neuronal dysfunction and inflammation due to leakage of membrane proteins, and may also lead to toxins or pathogens entering the CNS. In recent years, the development of nanotechnology has aimed to solve the problem that systemic chemotherapy is unable to precisely localize the tumour sites on one hand, and the permeability of chemotherapy agents on the other hand 33,107 . Meanwhile, the conjugate of DQA and other anti‐cancer drugs can inhibit drug‐resistant tumour growth and reduce systemic toxicity 108 .…”

Section: Limitationsmentioning

confidence: 99%

The potential value of dequalinium chloride in the treatment of cancer: Focus on malignant glioma

Pan

Zhao

Chen

2021

Clin Exp Pharma Physio

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Dequalinium chloride has been known as one kind of antibiotic that displays a broad antimicrobial spectrum and has been clinically proven to be very safe. In recent years, studies have shown that dequalinium chloride can inhibit the growth of malignant tumours, and reports were mainly used for solid tumours. Glioblastoma is the most common malignant neuroepithelial tumour of the central nervous system in adults, and the prognosis of glioblastoma is poor as it has a high resistance to apoptosis. This review summarizes the current understanding of dequalinium chloride‐induced cancer cell apoptosis and its potential role in glioblastoma resistance and progression. Particularly, we focus on dequalinium chloride as it exerts a wide range of anti‐cancer activity through its ability to target and accumulate in the mitochondria, and it effectively inhibits the growth of glioblastoma cells in vitro and vivo. Dequalinium chloride is an inhibitor of XIAP and can also act as a mitochondrial targeting agent, which gives it an interesting perspective regarding recent advances in the treatment of malignant glioma.

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“…By adopting a peptide linker, Mallick et al constructed an amphiphilic polymer composed of glycol chitosan (GC) and DQA. DQA was selected for mitochondria targeting as well as function as the lipophilic section of polymer that was able to self-assemble into nanoparticles in aqueous solvent (Mallick et al, 2019). The GC component facilitated the cellular uptake and subsequent endosomal escape with no evident toxicity.…”

Section: Non-tpp Lipophilic Cations For Mitochondria Targetingmentioning

confidence: 99%

Polymeric Nanoparticles for Mitochondria Targeting Mediated Robust Cancer Therapy

Sun

Yang

Xia

et al. 2021

Front. Bioeng. Biotechnol.

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Despite all sorts of innovations in medical researches over the past decades, cancer remains a major threat to human health. Mitochondria are essential organelles in eukaryotic cells, and their dysfunctions contribute to numerous diseases including cancers. Mitochondria-targeted cancer therapy, which specifically delivers drugs into the mitochondria, is a promising strategy for enhancing anticancer treatment efficiency. However, owing to their special double-layered membrane system and highly negative potentials, mitochondria remain a challenging target for therapeutic agents to reach and access. Polymeric nanoparticles exceed in cancer therapy ascribed to their unique features including ideal biocompatibility, readily design and synthesis, as well as flexible ligand decoration. Significant efforts have been put forward to develop mitochondria-targeted polymeric nanoparticles. In this review, we focused on the smart design of polymeric nanosystems for mitochondria targeting and summarized the current applications in improving cancer therapy.

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Self-assembled nanoparticles composed of glycol chitosan-dequalinium for mitochondria-targeted drug delivery

Cited by 36 publications

References 35 publications

Chitosan Nanoparticles at the Biological Interface: Implications for Drug Delivery

Chitosan Nanoparticles at the Biological Interface: Implications for Drug Delivery

The potential value of dequalinium chloride in the treatment of cancer: Focus on malignant glioma

Polymeric Nanoparticles for Mitochondria Targeting Mediated Robust Cancer Therapy

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