Self-assembled mPEG&amp;ndash;PCL-g&amp;ndash;PEI micelles for simultaneous codelivery of chemotherapeutic drugs and DNA: synthesis and characterization in vitro

Qian, Zhiyong

doi:10.2147/ijn.s28932

Cited by 18 publications

(6 citation statements)

References 34 publications

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“…MPEG-PCL di-block copolymer (MPEG 2000 –PCL 2000 , Mn = 4000) was synthesized by ring-opening polymerization of ε-CL and MPEG (weight ratio = 1:1), using Sn(Oct) 2 (account for 0.5% of total feed stock) as the catalyst (Shi et al., 2012 ; Wang et al., 2019b ). Briefly, a predetermined amount of ε-CL and MPEG were transferred into a dry glass flask under nitrogen atmosphere, and a small amount of Sn(Oct) 2 was added with mild agitation at 130 °C for 6 h. At the end of polymerization, the mixture was cooled to room temperature (RT) and dissolved in dichloromethane, and re-precipitated using AR grade excess cold petroleum ether.…”

Section: Methodsmentioning

confidence: 99%

Self-assembled dihydroartemisinin nanoparticles as a platform for cervical cancer chemotherapy

et al. 2020

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Dihydroartemisinin (DHA) is a potent anti-cancer drug that has limited clinical applications due to poor water solubility and low bioavailability. We designed a biodegradable poly(ethylene glycol) methyl ether-poly(ε-caprolactone) (MPEG-PCL) micelle carrier for DHA using the self-assembly method. The DHA/MPEG-PCL nanoparticles were spherical with an average particle size of 30.28 ± 0.27 nm, and released the drug in a sustained manner in aqueous solution. The drug-loaded nanoparticles showed dose-dependent toxicity in HeLa cells by inducing cycle arrest and apoptosis. Furthermore, compared to free DHA, the DHA/MPEG-PCL nanoparticles showed higher therapeutic efficacy and lower toxicity in vivo , and significantly inhibited tumor growth and prolonged the survival of tumor-bearing nude mice. In addition, the tumor tissues of the DHA/MPEG-PCL-treated mice showed a marked decline in the in situ expression of proliferation and angiogenesis markers. Taken together, the self-assembled DHA/MPEG-PCL nanoparticles are a highly promising delivery system for targeted cancer treatment.

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Section: Methodsmentioning

confidence: 99%

Self-assembled dihydroartemisinin nanoparticles as a platform for cervical cancer chemotherapy

et al. 2020

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“…Shi et al. (2012) designed a series of triblock copolymer, PEG–poly ε-caprolactone–polyethylenimine (mPEG–PCL-g–PEI), for co-delivery DNA plasmid and drugs. These copolymers could self-assemble into micelles with positive charge.…”

Section: Application Of Esterase-responsive Nanoparticles In Tumor Trmentioning

confidence: 99%

Application and design of esterase-responsive nanoparticles for cancer therapy

et al. 2019

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Nanoparticles have been developed for tumor treatment due to the enhanced permeability and retention effects. However, lack of specific cancer cells selectivity results in low delivery efficiency and undesired side effects. In that case, the stimuli-responsive nanoparticles system designed for the specific structure and physicochemical properties of tumors have attracted more and more attention of researchers. Esterase-responsive nanoparticle system is widely used due to the overexpressed esterase in tumor cells. For a rational designed esterase-responsive nanoparticle, ester bonds and nanoparticle structures are the key characters. In this review, we overviewed the design of esterase-responsive nanoparticles, including ester bonds design and nano-structure design, and analyzed the fitness of each design for different application. In the end, the outlook of esterase-responsive nanoparticle is looking forward.

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“…The majority of triblock copolymers used for co-delivery are used for the co-delivery of a drug and a gene 13, 85, 86 . Similarly to diblock copolymers used for the co-delivery of a gene and a drug, triblock copolymer carriers typically contain a hydrophobic drug encapsulated within the hydrophobic core and the nucleic acid complexed to one of the hydrophilic blocks (Figure 5, bottom row).…”

Section: Polymeric Micellar Nanoparticlesmentioning

confidence: 99%

Materials innovation for co-delivery of diverse therapeutic cargos

2013

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Co-delivery is a rapidly growing sector of drug delivery that aspires to enhance therapeutic efficacy through controlled delivery of diverse therapeutic cargoes with synergistic activities. It requires the design of carriers capable of simultaneously transporting to and releasing multiple therapeutics at a disease site. Co-delivery has arisen from the emerging trend of combination therapy, where treatment with two or more therapeutics at the same time can succeed where single therapeutics fail. However, conventional combination therapy offers little control over achieving an optimized therapeutic ratio at the target site. Co-delivery via inclusion of multiple therapeutic cargos within the same carrier addresses this issue by not only ensuring delivery of both therapeutics to the same cell, but also offering a platform for control of the delivery process, from loading to release. Co-delivery systems have been formulated using a number of carriers previously developed for single-therapeutic delivery. Liposomes, polymeric micelles, PLGA nanoparticles, and dendrimers have all been adapted for co-delivery. Much of the effort focuses on dealing with drugs having dissimilar properties, increasing loading efficiencies, and controlling loading and release ratios. In this review, we highlight the innovations in carrier designs and formulations to deliver combination cargoes of drug/drug, drug/siRNA, and drug/pDNA toward disease therapy. With rapid advances in mechanistic understanding of interrelating molecular pathways and development of molecular medicine, the future of co-delivery will become increasingly promising and prominent.

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Self-assembled mPEG–PCL-g–PEI micelles for simultaneous codelivery of chemotherapeutic drugs and DNA: synthesis and characterization in vitro

Cited by 18 publications

References 34 publications

Self-assembled dihydroartemisinin nanoparticles as a platform for cervical cancer chemotherapy

Self-assembled dihydroartemisinin nanoparticles as a platform for cervical cancer chemotherapy

Application and design of esterase-responsive nanoparticles for cancer therapy

Materials innovation for co-delivery of diverse therapeutic cargos

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