Application and design of esterase-responsive nanoparticles for cancer therapy

Dong, Haonan; Pang, Long; Cong, Hailin; Shen, Youqing; Yu, Bing

doi:10.1080/10717544.2019.1588424

Cited by 137 publications

(86 citation statements)

References 122 publications

(155 reference statements)

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“…PEG modification on the surface of nanoparticles could shield the surface from aggregation, opsonization, and phagocytosis, prolonging systemic circulation time. 34 According to the pH difference between tumor tissues and normal tissues, 35 pH-response FA-PEG-HZ-GO ligand was designed for the nanoparticle preparation. FA-CBP/PTX-LPNs were prepared by a one-step nanoprecipitation method.…”

Section: Discussionmentioning

confidence: 99%

<p>Combination Treatment of Cervical Cancer Using Folate-Decorated, pH-Sensitive, Carboplatin and Paclitaxel Co-Loaded Lipid-Polymer Hybrid Nanoparticles</p>

Wang¹

2020

DDDT

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Purpose: Cervical cancer is one of the most common causes of death among women globally. Combinations of cisplatin, paclitaxel, bevacizumab, carboplatin, topotecan, and gemcitabine are recommended as first-line therapies. Methods: This study focuses on the development of folate-decorated, pH-sensitive lipidpolymer hybrid nanoparticles (LPNs). Loading carboplatin (CBP) and paclitaxel (PTX), LPNs were expected to combine the therapeutic effects of CBP and PTX, thus show synergistic ability on cervical cancer. Results: FA-CBP/PTX-LPNs showed the sizes of 169.9 ± 5.6 nm, with a narrow size distribution of 0.151 ± 0.023. FA-CBP/PTX-LPNs exhibited pH-responsive drug release, high cellular uptake efficiency (66.7 ± 3.1%), and prominent cell inhibition capacity (23 ± 1.1%). In vivo tumor distribution and tumor inhibition efficiency of FA-CBP/PTX-LPNs was the highest, with no obvious body weight lost. Conclusion: High tumor distribution and remarkable antitumor efficiency obtained using in vitro as well as in vivo models further proved the FA-CBP/PTX-LPNs is a promising tool for cervical cancer therapy.

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Section: Discussionmentioning

confidence: 99%

<p>Combination Treatment of Cervical Cancer Using Folate-Decorated, pH-Sensitive, Carboplatin and Paclitaxel Co-Loaded Lipid-Polymer Hybrid Nanoparticles</p>

Wang¹

2020

DDDT

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“…Another approach is to introduce acidic-sensitive moiety in the micellar assembly to promote the SRD. Finally, an enzymatic driven degradation, for example, by an esterase, can be induced within the target tissue [115]. PLA is typically conjugated with an amphiphilic block copolymers (ABPs) to introduce hydrophilic residues in the hydrophobic structure of the biopolyesters.…”

Section: Stimuli-responsive Biopolymer-based Ddsmentioning

confidence: 99%

Recent Advances in Bioplastics: Application and Biodegradation

et al. 2020

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The success of oil-based plastics and the continued growth of production and utilisation can be attributed to their cost, durability, strength to weight ratio, and eight contributions to the ease of everyday life. However, their mainly single use, durability and recalcitrant nature have led to a substantial increase of plastics as a fraction of municipal solid waste. The need to substitute single use products that are not easy to collect has inspired a lot of research towards finding sustainable replacements for oil-based plastics. In addition, specific physicochemical, biological, and degradation properties of biodegradable polymers have made them attractive materials for biomedical applications. This review summarises the advances in drug delivery systems, specifically design of nanoparticles based on the biodegradable polymers. We also discuss the research performed in the area of biophotonics and challenges and opportunities brought by the design and application of biodegradable polymers in tissue engineering. We then discuss state-of-the-art research in the design and application of biodegradable polymers in packaging and emphasise the advances in smart packaging development. Finally, we provide an overview of the biodegradation of these polymers and composites in managed and unmanaged environments.

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“…A series of chemical anticancer drugs have been well developed and clinically used in these decades, such as doxorubicin (DOX) (Zhang et al, 2012;Fabbri et al, 2016), paclitaxel (PTX) (Markman & Mekhail, 2002;Yang et al, 2018), and camptothecin (CPT) (Venditto & Simanek, 2010;Llin as et al, 2018); however, these drugs are limited in the further clinical applications due to the serious side-effects caused by offtargeting and low therapeutic efficacy (Jungk et al, 2016;Yoshizawa et al, 2016). To overcome these obstacles, nanoscale drug delivery systems (DDSs) have attracted more and more attention and been extensively investigated (Chen et al, 2014), such as polymeric micelles (PMs), nanoparticles (NPs), prodrug, and liposome (Zhang et al, 2016;Zylberberg & Matosevic, 2016;Huang et al, 2018;Li et al, 2018;Dong et al, 2019). These effective DDSs are used to deliver hydrophobic or hydrophilic therapeutics which exhibit poor pharmacokinetics and high cytotoxicity to the site of tumor (Wang et al, 2016;Qin et al, 2017;Li et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Layer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacy in vivo

et al. 2020

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In this work, a pH-sensitive liposome-polymer nanoparticle (NP) composed of lipid, hyaluronic acid (HA) and poly(b-amino ester) (PBAE) was prepared using layer-by-layer (LbL) method for doxorubicin (DOX) targeted delivery and controlled release to enhance the cancer treatment efficacy. The NP with pH-sensitivity and targeting effect was successfully prepared by validation of charge reversal and increase of hydrodynamic diameter after each deposition of functional layer. We further showed the DOX-loaded NP had higher drug loading capacity, suitable particle size, spherical morphology, good uniformity, and high serum stability for drug delivery. We confirmed that the drug release profile was triggered by low pH with sustained release manner in vitro. Confocal microscopy research demonstrated that the NP was able to effectively target and deliver DOX into human non-small cell lung carcinoma (A549) cells in comparison to free DOX. Moreover, the blank NP showed negligible cytotoxicity, and the DOX-loaded NP could efficiently induce the apoptosis of A549 cells as well as free DOX. Notably, in vivo experiment results showed that the DOX-loaded NPs effectively inhibited the growth of tumor, enhanced the survival of tumor-bearing mice and improved the therapeutic efficacy with reduced side-effect comparing with free drug. Therefore, the NP could be a potential intelligent anticancer drug delivery carrier for cancer chemotherapy, and the LbL method might be a useful strategy to prepare multi-functional platform for drug delivery.

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Application and design of esterase-responsive nanoparticles for cancer therapy

Cited by 137 publications

References 122 publications

<p>Combination Treatment of Cervical Cancer Using Folate-Decorated, pH-Sensitive, Carboplatin and Paclitaxel Co-Loaded Lipid-Polymer Hybrid Nanoparticles</p>

<p>Combination Treatment of Cervical Cancer Using Folate-Decorated, pH-Sensitive, Carboplatin and Paclitaxel Co-Loaded Lipid-Polymer Hybrid Nanoparticles</p>

Recent Advances in Bioplastics: Application and Biodegradation

Layer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacy in vivo

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