Self-Assembled Monolayers of Oligo(ethylene glycol)-Terminated and Amide Group Containing Alkanethiolates on Gold

Valiokas, Ramūnas; Svedhem, Sofia; Svensson, and Stefan C. T.; Liedberg, Bo

doi:10.1021/la981647o

Cited by 120 publications

(219 citation statements)

References 33 publications

(54 reference statements)

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“…The results overall were in good agreement with data presented in previous studies of Lac1-3 (Fyrner et al 2013), Mal-tri (Fyrner et al 2011) and of OEG-terminated SAMs (Valiokas et al 1999, Valiokas et al 2000. For the three SAMs Lac1-3, it is concluded from both the thicknesses and the IRAS data (showing that the amide carbonyl bonds are parallel to the surface), that the monolayers all formed with the hydrocarbon spacers in a near-upright conformation, and that the orientation of the sugar moieties were similar in all cases.…”

Section: Sam Structuresupporting

confidence: 91%

Antifouling properties of oligo(lactose)-based self-assembled monolayers

et al. 2015

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The antifouling properties of oligo(lactose)-based self-assembled monolayers (SAMs), using four different proteins, zoospores of the green alga Ulva linza and cells of the diatom Navicula incerta, were investigated. The SAM-forming alkylthiols, which contained 1, 2 or 3 lactose units, showed significant variation in antifouling properties, with no differences in wettability.Non-specific adsorption of albumin and pepsin was low on all surfaces. Adsorption of lysozyme and fibrinogen decreased with increasing number of lactose units in the SAM, in agreement with the generally observed phenomenon that thicker hydrated layers provide higher barriers to protein adsorption. Settlement of spores of U. linza followed an opposite trend, being greater on the bulkier, more hydrated SAMs. These SAMs are more ordered for the larger saccharide units, and it is therefore hypothesized that the degree of order, and differences in crystallinity or stiffness between the surfaces, is an important parameter regulating spore settlement on these surfaces.

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Section: Sam Structuresupporting

confidence: 91%

Antifouling properties of oligo(lactose)-based self-assembled monolayers

et al. 2015

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“…c After incubation for 3-6 h, cells adhered on the substrate everywhere except for SAM areas (gray area). The areas between two neighboring dash lines were that of the previous microchannels previous studies of SAMs on gold surfaces, the longer chain length thiols formed the thicker SAM films [25,26]. We speculated that the limited space between the gold surface and the PDMS stamp favors short chain length thiols diffusion to form SAMs.…”

Section: Resultsmentioning

confidence: 64%

Diffusion of self-assembled monolayers of thiols on the gold surfaces covered with polydimethylsiloxane stamps

et al. 2014

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Thiols can diffuse and form self-assembled monolayers (SAMs) on the gold surfaces covered with polydimethylsiloxane (PDMS) stamps. For the first time, with cells as the indicator of how far alkanethiols had diffused to form SAM, we studied the growth dynamics of SAMs of HS(CH 2 ) 11 (OCH 2 CH 2 ) 3 OH (EG 3 ) and HS(CH 2 ) 11 (OCH 2 CH 2 ) 6 OH (EG 6 ) on the gold surfaces covered with PDMS stamps. The growth of SAMs is well described by one-dimensional diffusion from a line source of concentration, with surface diffusion coefficient of 193.4 ± 19.2 lm 2 /min (EG 3 ) and 95.8 ± 18.9 lm 2 /min (EG 6 ).

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“…Alkylthiolates containing ethylene glycol reduce the non-specific binding of proteins, bacteria, and cells to Au and Si surfaces. [37][38][39][40][41][42][43][44][45][46] We show that insulating TEG and BAT monolayers on Au surfaces were adsorbed from water at faster rates and with fewer monolayer pinholes than SAMs adsorbed from ethanol. Finally, electrochemical techniques efficiently remove contaminants from Au surfaces to enhance alkylthiolate monolayer formation in a manner that is addressable on a nanometer scale and does not damage the Au surfaces during repeated cleaning.…”

Section: Introductionmentioning

confidence: 76%

Formation and removal of alkylthiolate self-assembled monolayers on gold in aqueous solutions

Canaria

Maloney

et al. 2006

Lab Chip

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We report the development of novel reagents and approaches for generating recyclable biosensors. The use of aqueous media for the formation of protein binding alkylthiolate monolayers on Au surfaces results in accelerated alkylthiolate monolayer formation and improvement in monolayer integrity as visualized by fluorescence microscopy and CV techniques. We have also developed an electrocleaning protocol that is compatible with microfluidics devices, and this technique serves as an on-chip method for cleaning Au substrates both before and after monolayer formation. The techniques for the formation and dissociation of biotinylated SAMs from aqueous solvents reported here may be applied towards the development of Au-based sensor devices and microfluidics chips in the future. A potential use of these devices includes the specific capture and triggered release of target cells, proteins, or small molecules from liquid samples.

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Self-Assembled Monolayers of Oligo(ethylene glycol)-Terminated and Amide Group Containing Alkanethiolates on Gold

Cited by 120 publications

References 33 publications

Antifouling properties of oligo(lactose)-based self-assembled monolayers

Antifouling properties of oligo(lactose)-based self-assembled monolayers

Diffusion of self-assembled monolayers of thiols on the gold surfaces covered with polydimethylsiloxane stamps

Formation and removal of alkylthiolate self-assembled monolayers on gold in aqueous solutions

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