Self-assembled hyaluronic acid nanoparticles for active tumor targeting

Cancer is the second worldwide cause of death, exceeded only by cardiovascular diseases. It is characterized by uncontrolled cell proliferation and an absence of cell death that, except for hematological cancers, generates an abnormal cell mass or tumor. This primary tumor grows thanks to new vasculatization and, in time, adquires metastatic potential and spreads to other body sites, which causes metastasis and finally death. Cancer is caused by damage or mutations in the genetic material of the cells due to environmental or inherited factors. While surgery and radiotherapy are the primary treatment used for local and non-metastatic cancers, anti-cancer drugs (chemotherapy, hormone and biological therapies) are the choice currently used in metastasic cancers. Chemotherapy is based on the inhibition of the division of rapidly growing cells, which is a characteristic of the cancerous cells, but unfortunately, it also affects normal cells with fast proliferation rates, like the hair follicles, bone marrow and gastrointestinal tract cells, generating the characteristic side effects of chemotherapy. The indiscriminate destruction of normal cells, the toxicity of conventional chemotherapeutic Código de campo cambiado

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“…Choi et al [488] designed self-assembled amphiphilic hyaluronic acid nanoparticles to actively target …”

Section: Hyaluronic Acid-based Targetingmentioning

confidence: 99%

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

Pérez-Herrero

Fernández‐Medarde

2015

European Journal of Pharmaceutics and Biopharmaceutics

1,326

754

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“…The strong florescent signals detected in the cytoplasm indicated HA-NPs were readily taken by the cancer cells receptor-mediated endocytosis. In addition, the florescent signals were stronger at the tumor site than in the normal tissues ( Figure 6) indicating appreciable tumor targeting, which the authors suggested may be due to enhanced permeation and retention (EPR) effect as well as receptor-mediated endocytosis of HA-NPs [75]. In summary self-assembled HA-NPs can be utilized for as targeted drug carriers and or imaging agents for therapy and monitoring of therapeutic efficacy of the incorporated drug.…”

Section: Natural Polymers For Theranosticsmentioning

confidence: 95%

“…However, natural polysaccharides due to their excellent biocompatibility, low toxicity, biodegradability and functionalities that the body can identify with, make them excellent materials for theranostics. Self-assembled modified hyaluronic acid (HA) derivatized nanoparticles were fabricated for tumor targeting [75]. First, amphiphilic HA was conjugated with 5β-cholanic acid to form HA-CA conjugates.…”

Section: Natural Polymers For Theranosticsmentioning

confidence: 99%

Naturapolyceutics: The Science of Utilizing Natural Polymers for Drug Delivery

2014

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Naturapolyceutics defines the emerging science and technology platform that blends natural polymers and pharmaceutics for the design and development of drug delivery systems. Natural polymers due to their biological properties, sustainability, chemical flexibility, human and eco-friendliness are promising in this field. As drug delivery advances, there will be need for more polymers. Given that polymers utilized in pharmaceuticals require regulatory approval, robust processes are undertaken to facilitate the production of pharmaceutical grade natural polymers. This review provides insight into the processes-extraction, purification, modifications and characterizations-involved in the eventual utilization of natural polymers for drug delivery. The versatility of natural polymers and particularly modified natural polymers in targeted drug delivery, micro-/nano-drug delivery, theranostics, BioMEMs and generally in research and development of highly efficient, safe and quality products is demonstrated. Natural polymers are polymers of today and tomorrow. Therefore, the shift to undertake training, extensive research and subsequent commercialization of more natural polymers-novel and underutilized-for drug delivery is now!

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“…Apart from cholesterol, 5 -Cholanic acid is a non-toxic bile acid present in humans that can be chosen as the hydrophobic moiety to be attached to hyaluronic acid in order to form amphiphilic conjugates. The mean diameters of the obtained nanoparticles are in the range of 237-424 nm (Choi et al, 2010).…”

Section: Nanoparticles Obtained From Self-assembling Of Hydrophobicalmentioning

confidence: 96%