Self-assembled amphiphilic zein-lactoferrin micelles for tumor targeted co-delivery of rapamycin and wogonin to breast cancer

Sabra, Sally; Elzoghby, Ahmed O.; Sheweita, Salah A.; Haroun, Medhat A.; Helmy, Maged W.; El-Demellawy, Maha; Xia, Ying; Goodale, David; Allan, Alison L.; Rohani, Sohrab

doi:10.1016/j.ejpb.2018.04.023

Cited by 131 publications

(67 citation statements)

References 61 publications

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“…Moreover, the intravenous injection of Dox-loaded holo-bLf-liposomes in a murine model of breast cancer resulted, along with a high accumulation of the nanocomposites in the tumor site, in tumor suppression and in a higher induction, when compared to mice treated with the sole Dox-loaded liposomes, of hydrogen peroxide conversion to oxygen, due to the release of ferric ions following holo-bLf degradation [202]. Similarly, bLf-containing micelles were used for the efficient targeting of both rapamycin and wogonin to treat breast cancer cells [203]. In general, bLf-micelles showed good serum stability and blood compatibility.…”

Section: Lactoferrin As a Cargo For Cancer Targetingmentioning

confidence: 99%

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Lactoferrin’s Anti-Cancer Properties: Safety, Selectivity, and Wide Range of Action

et al. 2020

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Despite recent advances in cancer therapy, current treatments, including radiotherapy, chemotherapy, and immunotherapy, although beneficial, present attendant side effects and long-term sequelae, usually more or less affecting quality of life of the patients. Indeed, except for most of the immunotherapeutic agents, the complete lack of selectivity between normal and cancer cells for radioand chemotherapy can make them potential antagonists of the host anti-cancer self-defense over time. Recently, the use of nutraceuticals as natural compounds corroborating anti-cancer standard therapy is emerging as a promising tool for their relative abundance, bioavailability, safety, low-cost effectiveness, and immuno-compatibility with the host. In this review, we outlined the anti-cancer properties of Lactoferrin (Lf), an iron-binding glycoprotein of the innate immune defense. Lf shows high bioavailability after oral administration, high selectivity toward cancer cells, and a wide range of molecular targets controlling tumor proliferation, survival, migration, invasion, and metastasization. Of note, Lf is able to promote or inhibit cell proliferation and migration depending on whether it acts upon normal or cancerous cells, respectively. Importantly, Lf administration is highly tolerated and does not present significant adverse effects. Moreover, Lf can prevent development or inhibit cancer growth by boosting adaptive immune response. Finally, Lf was recently found to be an ideal carrier for chemotherapeutics, even for the treatment of brain tumors due to its ability to cross the blood-brain barrier, thus globally appearing as a promising tool for cancer prevention and treatment, especially in combination therapies.

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Section: Lactoferrin As a Cargo For Cancer Targetingmentioning

confidence: 99%

“…In general, bLf-micelles showed good serum stability and blood compatibility. Additionally, they were found to increase cytotoxicity of rapamycin and wogonin in terms of tumor inhibition in in vitro and in vivo models as a result of enhanced active targeting [203].…”

Section: Lactoferrin As a Cargo For Cancer Targetingmentioning

confidence: 99%

Lactoferrin’s Anti-Cancer Properties: Safety, Selectivity, and Wide Range of Action

et al. 2020

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“…The obtained sizes were, however, slightly smaller than the diameters determined by dynamic light scattering. Dynamic light scattering reflects particle size in its swollen state, whereas TEM reflects it in the dried state [18], and these differences may be responsible for the discrepancy between the results. Figure 1B shows the colloidal stability of various liposomes for 3 weeks.…”

Section: Characterization Of Liposomesmentioning

confidence: 95%

Enhanced Intracellular Delivery of BCG Cell Wall Skeleton into Bladder Cancer Cells Using Liposomes Functionalized with Folic Acid and Pep-1 Peptide

et al. 2019

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Although bacillus Calmette–Guérin cell wall skeleton (BCG-CWS) might function as a potential substitute for live BCG, its use in the treatment of bladder cancer remains limited owing to issues such as insolubility and micrometer-size following exposure to an aqueous environment. Thus, to develop a novel nanoparticulate system for efficient BCG-CWS delivery, liposomal encapsulation was carried out using a modified emulsification-solvent evaporation method (targets: Size, <200 nm; encapsulation efficiency, ~60%). Further, the liposomal surface was functionalized with specific ligands, folic acid (FA), and Pep-1 peptide (Pep1), as targeting and cell-penetrating moieties, respectively. Functionalized liposomes greatly increased the intracellular uptake of BCG-CWS in the bladder cancer cell lines, 5637 and MBT2. The immunoactivity was verified through elevated cytokine production and a THP-1 migration assay. In vivo antitumor efficacy revealed that the BCG-CWS-loaded liposomes effectively inhibited tumor growth in mice bearing MBT2 tumors. Dual ligand-functionalized liposome was also superior to single ligand-functionalized liposomes. Immunohistochemistry supported the enhanced antitumor effect of BCG-CWS, with IL-6 production and CD4 infiltration. Thus, we conclude that FA- and Pep1-modified liposomes encapsulating BCG-CWS might be a good candidate for bladder cancer treatment with high target selectivity.

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“…Combination drug therapy in cancer can have additive or synergistic effects, minimize drug resistance, or fight against expected resistance resulting in better safety and efficacy. In our laboratory, we have used a drug combination of the herbal drug wogonin (WOG) and rapamycin (RAP) coencapsulated into amphiphilic zein-lactoferrin nano-micelles for breast cancer therapy [24]. WOG can synergistically circumvent the feedback survival activation pathway induced by RAP monotherapy by initially arresting mTOR/PI3K/AKT pathways.…”

Section: Enabled Synergistic Combinationsmentioning

confidence: 99%

“…WOG can synergistically circumvent the feedback survival activation pathway induced by RAP monotherapy by initially arresting mTOR/PI3K/AKT pathways. Coadministration of the dual drug-loaded micelles into Ehrlich's mammary tumor-bearing mice has maximized the antitumor efficacy demonstrated as synergistic decrease in tumor volume to about 29.27% compared to the control group showing progressive rise in tumor volume (717.43%) after 3 weeks of treatment [24]. For targeting of gastric cancer, the herbal drug ginsenoside was co-incorporated with paclitaxel inside liposomes [25].…”

Section: Enabled Synergistic Combinationsmentioning

confidence: 99%

Nanomedicine-based approaches for improved delivery of phyto-therapeutics for cancer therapy

Hafez

Elkhodairy

Teleb

et al. 2020

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Self-assembled amphiphilic zein-lactoferrin micelles for tumor targeted co-delivery of rapamycin and wogonin to breast cancer

Cited by 131 publications

References 61 publications

Lactoferrin’s Anti-Cancer Properties: Safety, Selectivity, and Wide Range of Action

Lactoferrin’s Anti-Cancer Properties: Safety, Selectivity, and Wide Range of Action

Enhanced Intracellular Delivery of BCG Cell Wall Skeleton into Bladder Cancer Cells Using Liposomes Functionalized with Folic Acid and Pep-1 Peptide

Nanomedicine-based approaches for improved delivery of phyto-therapeutics for cancer therapy

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