Self‐assembled amphiphilic poly‐N‐vinylpyrrolidone nanoparticles as carriers for hydrophobic drugs: Stability aspects

Abstract

Nanoparticles can experience numerous impacts during storage or after intravenous administration resulting in disassembly and/or drug leakage and affecting their efficiency as drug delivery systems. In this study, this crucial issue was addressed by investigating the stability of amphiphilic poly-N-vinylpyrrolidone derivative nanocarriers in blood serum, against destabilizing agents and during long-term storage. All amphiphilic poly-N-vinylpyrrolidone derivative nanoparticles prepared in this study were found to possess sizes less than 150 nm, narrow size distribution, spherical morphology, and a slightly negative surface charge. These nanoparticles could efficiently entrap hydrophobic substances (pyrene and curcumin) while retaining excellent compatibility with red blood cells. Moreover, our studies demonstrate the stability of the nanoparticles during long-term storage and upon dilution with body liquids enhancing their potential as stable in vivo carriers, which is critically important for intravenous drug delivery applications. All properties were found to strongly depend on the ratio between the hydrophobic and the hydrophilic moiety of the polymers under study.

N-octyl chitosan derivatives as amphiphilic carrier agents for herbicide formulations

“…The amphiphilic chitosan derivatives have ability to self-assemble into micelles and load a waterinsoluble compound into their hydrophobic core [16]. The application of amphiphilic chitosan derivatives could increase the solubility of hydrophobic pesticide in water while controlling the release of the pesticide [17,18].…”

Reprogramming of CaCo2 colorectal cancer cells after using the complex of poly-(N-vinylpyrrolidone) with small non-coding RNAs

“…An amphiphilic Poly-(N-vinylpyrrolidone), with an Mn = 3500, containing one hydrophobic n-octadecyl end group was used. The side groups of amino acid β-alanin were introduced in 8 mol % of polymer rings by the recently described method [[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]]. The overage diameter of particles was approximately 100 nm.…”

Glycosaminoglycans: Carriers and Targets for Tailored Anti-Cancer Therapy

“…Micro- and nanoencapsulation [ 84 , 85 , 86 ], micellar [ 87 , 88 ], and liposomal [ 89 ] forms, dendrimers [ 90 ], mesoporous particles [ 91 ], and nanogels [ 92 ] are used most often for targeted drug delivery. A wide range of compounds, both synthetic [ 93 , 94 ] and natural [ 86 , 87 , 89 , 92 ], are used as materials, and each of the groups has several advantages and disadvantages ( Table 1 ).…”

“…Indeed, HA micelles can effectively deliver hydrophobic drugs to target cancer cells while simultaneously facilitating bioavailability and the half-life of the utilized drugs [ 111 ]. Importantly, nanoparticles can be loaded with various types of drugs, both hydrophilic and lipophilic, as well as DNA, RNA, peptides, and proteins [ 85 , 88 , 112 , 113 ].…”