Self-assembled amphiphilic mixed α/β-tetrapeptoid nanostructures as promising drug delivery vehicles

Goel, Rahul; Sharma, Ashwani; Gupta, Atul

doi:10.1039/c6nj03281h

Cited by 11 publications

(12 citation statements)

References 49 publications

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“…It was found out that the hydrophobic pocket of the supramolecular structures formed shows remarkable affinity towards aspirin, l -Dopa, and other hydrophobic materials. 188…”

Section: Applications Of Self-assembled Hybrid Peptidesmentioning

confidence: 99%

“…The size and morphology of the nanovesicular structure were confirmed by TEM. 188 Sanjayan and his group successfully fabricated a hollow vesicular morphology through concentration and solvent-assisted self-assembly of a urea mounted nonamphiphilic anthranilic acid-proline octapeptide. Herein, urea groups drove the molecule towards vesicle formation, and the inner hydrophobic cavity showed an encapsulation property (Fig.…”

Section: Reviewmentioning

confidence: 99%

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Advances in hybrid peptide-based self-assembly systems and their applications

Boruah

Roy

2022

Biomater. Sci.

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“…It was found out that the hydrophobic pocket of the supramolecular structures formed shows remarkable affinity towards aspirin, l -Dopa, and other hydrophobic materials. 188…”

Section: Applications Of Self-assembled Hybrid Peptidesmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Advances in hybrid peptide-based self-assembly systems and their applications

Boruah

Roy

2022

Biomater. Sci.

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“…Zero order, First order, Korsmeyer peppas and Higuchi. 39,40 Different polymers follow different kinetics for releasing the peptide. Detailed explanations of all models are given in Supplementary Material (S5)…”

Section: Fourier Transform Infra-red Analysismentioning

confidence: 99%

Polyaspartic acid, 2-acrylamido-2-Methyl propane sulfonic acid and sodium alginate based biocompatible stimuli responsive polymer gel for controlled release of GHK-Cu peptide for wound healing

et al. 2022

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Stimuli responsive polymer based on Polyaspartic acid, 2-Acrylamido-2-methylpropane sulfonic acid and sodium alginate (NaAlg) were synthesized using two cross-linkers Ethylene glycol dimethacrylate (EGDMA) and TMPTA (Trimethylolpropane triacrylate). The polymers were standardized and optimized to obtain a polymer with maximum swelling in distilled water, saline, glucose and solutions of varying pH. The synthesized polymer swelled well in distilled water, glucose solution and acidic- alkaline medium. The biocompatibility of the polymer was evaluated for blood compatibility and protein adsorption. The polymer with maximum swelling property was used for peptide release studies. The polymer was further used to study the peptide encapsulation and release efficiency of the polymeric material which was confirmed by FTIR, Scanning Emission Microscope and EDX. The encapsulation efficiency of the polymer for encapsulating (glycyl-l-histidyl-l-lysine-copper) GHK-Cu was observed to be 55.26% and peptide release of 51.84% was observed for Ethylene glycol dimethacrylate based polymer after 24 h whereas for Trimethylolpropane triacrylate based polymer the encapsulation efficiency was observed to be 49.6% and release was 39.01%. The EGDMA based polymer was further examined under in vivo studies in order to evaluate the efficiency of the synthesized polymer. The in vivo studies include wound closure, histopathological analysis, biochemical and toxicity assay. The material has shown promising results for both in vivo and in vitro studies.

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“…The encapsulation efficiency was measured by comparing the UV absorption spectra of peptide-loaded polymeric sample using calibration curve of peptide , (SI3).…”

Section: Experimental Sectionmentioning

confidence: 99%

“…The amount of peptide release was measured at 605 nm using UV spectrophotometer at predetermined time intervals, i.e., 1, 2, 3, 4, and 24 h. Aliquot (3 mL) was used for absorbance measurement. Volume of the solution was maintained by returning back aliquots after measurement , (SI4).…”

Section: Experimental Sectionmentioning

confidence: 99%

In Vitro and in Vivo Studies of pH-Sensitive GHK-Cu-Incorporated Polyaspartic and Polyacrylic Acid Superabsorbent Polymer

Sharma

Anwar²,

Dinda³

et al. 2019

ACS Omega

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The main aim of this study was to evaluate the in vitro and in vivo efficiency of the polyaspartic acid- and acrylic acid-based superabsorbent polymer. The synthesized polymer was first investigated to check the blood compatibility by protein adsorption and blood clotting tests. Further, the GHK-Cu peptide was incorporated within the polymer and release studies were performed to evaluate the drug-delivery efficiency of the superabsorbent polymer. The polymer with best peptide release results were further used for in vivo analysis for wound healing. The healing efficiency of polymer with and without peptide was analyzed using wound closure, biochemical assay, histopathological, and toxicity studies.

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Self-assembled amphiphilic mixed α/β-tetrapeptoid nanostructures as promising drug delivery vehicles

Abstract: Tetrapeptoid nanostructures have been prepared and their potential used for delivering hydrophobic drug molecules.

Cited by 11 publications

References 49 publications

Advances in hybrid peptide-based self-assembly systems and their applications

Advances in hybrid peptide-based self-assembly systems and their applications

Polyaspartic acid, 2-acrylamido-2-Methyl propane sulfonic acid and sodium alginate based biocompatible stimuli responsive polymer gel for controlled release of GHK-Cu peptide for wound healing

In Vitro and in Vivo Studies of pH-Sensitive GHK-Cu-Incorporated Polyaspartic and Polyacrylic Acid Superabsorbent Polymer

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