Self-Amplification of Tumor Oxidative Stress with Degradable Metallic Complexes for Synergistic Cascade Tumor Therapy

Chen, Gui; Yang, Yuanyuan; Xu, Qing; Ling, Mingjian; Lin, Huimin; Wen, Ming‐Shien; Sun, Rui; Xu, Yuchun; Liu, Xiqiang; Li, Nan; Yu, Zhiqiang; Yu, Meng

doi:10.1021/acs.nanolett.0c03127

Cited by 174 publications

(98 citation statements)

References 64 publications

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“…In recent years, diverse efforts based on GSH depletion or H 2 O 2 concentration elevation have been made to improve the anticancer efficiency triggered by Fenton and Fenton-like reactions [ 11 , 83 , 84 ]. GSH is overexpressed in many types of cancer cells and can reduce the ROS that are generated by Fenton- and Fenton-like reactions, thereby decreasing the therapeutic effect of CDT [ 85 – 87 ]. Therefore, in one study, the GSH depletion agent, sabutoclax, was loaded into Fe 3+ -containing nanoparticles (NPs) in order to produce the synergistic effect of Fe 3+ -mediated Fenton reactions and sabutoclax-induced GSH depletion [ 51 ].…”

Section: Introductionmentioning

confidence: 99%

Chemodynamic nanomaterials for cancer theranostics

et al. 2021

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It is of utmost urgency to achieve effective and safe anticancer treatment with the increasing mortality rate of cancer. Novel anticancer drugs and strategies need to be designed for enhanced therapeutic efficacy. Fenton- and Fenton-like reaction-based chemodynamic therapy (CDT) are new strategies to enhance anticancer efficacy due to their capacity to generate reactive oxygen species (ROS) and oxygen (O2). On the one hand, the generated ROS can damage the cancer cells directly. On the other hand, the generated O2 can relieve the hypoxic condition in the tumor microenvironment (TME) which hinders efficient photodynamic therapy, radiotherapy, etc. Therefore, CDT can be used together with many other therapeutic strategies for synergistically enhanced combination therapy. The antitumor applications of Fenton- and Fenton-like reaction-based nanomaterials will be discussed in this review, including: (iþ) producing abundant ROS in-situ to kill cancer cells directly, (ii) enhancing therapeutic efficiency indirectly by Fenton reaction-mediated combination therapy, (iii) diagnosis and monitoring of cancer therapy. These strategies exhibit the potential of CDT-based nanomaterials for efficient cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Chemodynamic nanomaterials for cancer theranostics

et al. 2021

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“…In particular, nanoplatforms with these nanostructures fabricated by self‐assembled strategies have demonstrated extensive advantages during the laboratory and preclinical studies for theranostics of cancer. [ 22–25 ]…”

Section: Introductionmentioning

confidence: 99%

Self‐assembled magnetic nanomaterials: Versatile theranostics nanoplatforms for cancer

Wang

Hou

2021

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Self‐assembled magnetic nanomaterials (MNMs) are a class of promising biomaterials possessing excellent physiochemical and biological characteristics, making them highly attractive in biomedical applications. A myriad of magnetic nanosystems can be created by using self‐assembly as a synthetic tool. Favorable nano‐bio interfacial properties are shown in these promising self‐assembled magnetic nanosystems, while still retaining their physical/chemical functionalities. This review aims to provide a systematical overview of the self‐assembled MNMs. In addition, this review highlights their implementations in cancer theranostics in detail. Overall, this review points out the direction for the application of self‐assembled MNMs in biomedicine, and presents how clinical oncology could benefit from the self‐assembled nanotechnology.

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“…Mitochondria, as so-called cell powerhouses, are the main intracellular sources of reactive oxygen species (ROS) [ 17 ]. Excessive ROS production, known as oxidative stress, can lead to oxidative damage and reduced mitochondrial energy production efficiency, which further increases ROS generation and causes mitochondrial damage to form a “vicious circle” [ 12 , 18 , 19 ]. However, cancer cells normally possess a powerful antioxidant system to balance the increased level of intracellular ROS [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Amplification of oxidative stress with lycorine and gold-based nanocomposites for synergistic cascade cancer therapy

Yang

Liang

et al. 2021

J Nanobiotechnol

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Background Despite advances of surgery and neoadjuvant chemotherapy during the past few decades, the therapeutic efficacy of current therapeutic protocol for osteosarcoma (OS) is still seriously compromised by multi-drug resistance and severe side effects. Amplification of intracellular oxidative stress is considered as an effective strategy to induce cancer cell death. The purpose of this study was to develop a novel strategy that can amplify the intracellular oxidative stress for synergistic cascade cancer therapy. Methods and results A novel nanocomposite, composed of folic acid (FA) modified mesoporous silica–coated gold nanostar (GNS@MSNs-FA) and traditional Chinese medicine lycorine (Ly), was rationally designed and developed. Under near-infrared (NIR) irradiation, the obtained GNS@MSNs-FA/Ly could promote a high level of ROS production via inducing mitochondrial dysfunction and potent endoplasmic reticulum (ER) stress. Moreover, glutathione (GSH) depletion during ER stress could reduce ROS scavenging and further enable efficient amplification of intracellular oxidative stress. Both in vitro and in vivo studies demonstrated that GNS@MSNs-FA/Ly coupled with NIR irradiation exhibited excellent antitumor efficacy without noticeable toxicity in MNNG/HOS tumor-bearing mice. Conclusion All these results demonstrated that GNS@MSNs-FA/Ly coupled with NIR irradiation could dramatically amplify the intra-tumoral oxidative stress, exhibiting excellent antitumor ability without obvious systemic toxicity. Taken together, this promising strategy provides a new avenue for the effective cancer synergetic therapy and future clinical translation.

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Self-Amplification of Tumor Oxidative Stress with Degradable Metallic Complexes for Synergistic Cascade Tumor Therapy

Cited by 174 publications

References 64 publications

Chemodynamic nanomaterials for cancer theranostics

Chemodynamic nanomaterials for cancer theranostics

Self‐assembled magnetic nanomaterials: Versatile theranostics nanoplatforms for cancer

Amplification of oxidative stress with lycorine and gold-based nanocomposites for synergistic cascade cancer therapy

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