Self‐aggregated nanoparticles of <i>N</i>‐dodecyl,<i>N</i>′‐glycidyl(chitosan) as pH‐responsive drug delivery systems for quercetin

Pedro, Rafael de Oliveira; Pereira, Susana; Goycoolea, Francisco M.; Cavalheiro, Carla Cristina Schmitt; Neumann, Miguel G.

doi:10.1002/app.45678

Cited by 20 publications

(9 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This product was grafted on collagen or nisin to obtain the sorbent materials suitable for pharmaceutic and medical applications [ 35 , 36 ]. Similar hydroxyalkylation with glycidol was also reported [ 37 ]. Generally, the chitosan hydroxyalkylated with epoxides can be further substituted with carboxyl groups [ 38 , 39 ].…”

Section: Introductionsupporting

confidence: 85%

Polyols and Polyurethane Foams Based on Water-Soluble Chitosan

Strzałka

Lubczak

2023

Polymers

View full text Add to dashboard Cite

At present, majority of polyols used in the synthesis of polyurethane foams are of petrochemical origin. The decreasing availability of crude oil imposes the necessity to convert other naturally existing resources, such as plant oils, carbohydrates, starch, or cellulose, as substrates for polyols. Within these natural resources, chitosan is a promising candidate. In this paper, we have attempted to use biopolymeric chitosan to obtain polyols and rigid polyurethane foams. Four methods of polyol synthesis from water-soluble chitosan functionalized by reactions of hydroxyalkylation with glycidol and ethylene carbonate with variable environment were elaborated. The chitosan-derived polyols can be obtained in water in the presence of glycerol or in no-solvent conditions. The products were characterized by IR, 1H-NMR, and MALDI-TOF methods. Their properties, such as density, viscosity, surface tension, and hydroxyl numbers, were determined. Polyurethane foams were obtained from hydroxyalkylated chitosan. The foaming of hydroxyalkylated chitosan with 4,4′-diphenylmethane diisocyanate, water, and triethylamine as catalysts was optimized. The four types of foams obtained were characterized by physical parameters such as apparent density, water uptake, dimension stability, thermal conductivity coefficient, compressive strength, and heat resistance at 150 and 175 °C. It has been found that the obtained materials had most of the properties similar to those of classic rigid polyurethane foams, except for an increased thermal resistance up to 175 °C. The chitosan-based polyols and polyurethane foams obtained from them are biodegradable: the polyol is completely biodegraded, while the PUF obtained thereof is 52% biodegradable within 28 days in the soil biodegradation oxygen demand test.

show abstract

Section: Introductionsupporting

confidence: 85%

Polyols and Polyurethane Foams Based on Water-Soluble Chitosan

Strzałka

Lubczak

2023

Polymers

View full text Add to dashboard Cite

show abstract

“…The results further revealed that the incubation time of the cells with QCT is directly related to the reduction of cell viability, which suggests that a higher incubation time would have led to higher toxicity. In addition, recent studies have confirmed the bioavailability and effectiveness of QCT against MCF-7 cells [7,51,52].…”

Section: Mtt Assaymentioning

confidence: 85%

Self-assembled amphiphilic chitosan nanoparticles for quercetin delivery to breast cancer cells

Pedro

Hoffmann

Pereira

et al. 2018

European Journal of Pharmaceutics and Biopharmaceutics

Self Cite

View full text Add to dashboard Cite

“…Pedro et al synthesized N -dodecyl- N ′-glycidyl(chitosan) for the delivery of quercetin [ 189 ]. The hydrodynamic parameters of quercetin loaded hydrophobically modified CS micelles were measured by dynamic light scattering showing sizes from 140 to 260 nm and Zeta-potential values from +18.7 to +30.4 mV at pH 7.4.…”

Section: Hydrophobic Modification Of Chitosan and Derivatives For mentioning

confidence: 99%

Chitosan Based Self-Assembled Nanoparticles in Drug Delivery

2018

View full text Add to dashboard Cite

Abstract:Chitosan is a cationic polysaccharide that is usually obtained by alkaline deacetylation of chitin poly(N-acetylglucosamine). It is biocompatible, biodegradable, mucoadhesive, and nontoxic. These excellent biological properties make chitosan a good candidate for a platform in developing drug delivery systems having improved biodistribution, increased specificity and sensitivity, and reduced pharmacological toxicity. In particular, chitosan nanoparticles are found to be appropriate for non-invasive routes of drug administration: oral, nasal, pulmonary and ocular routes. These applications are facilitated by the absorption-enhancing effect of chitosan. Many procedures for obtaining chitosan nanoparticles have been proposed. Particularly, the introduction of hydrophobic moieties into chitosan molecules by grafting to generate a hydrophobic-hydrophilic balance promoting self-assembly is a current and appealing approach. The grafting agent can be a hydrophobic moiety forming micelles that can entrap lipophilic drugs or it can be the drug itself. Another suitable way to generate self-assembled chitosan nanoparticles is through the formation of polyelectrolyte complexes with polyanions. This paper reviews the main approaches for preparing chitosan nanoparticles by self-assembly through both procedures, and illustrates the state of the art of their application in drug delivery.

show abstract

Self‐aggregated nanoparticles of N‐dodecyl,N′‐glycidyl(chitosan) as pH‐responsive drug delivery systems for quercetin

Cited by 20 publications

References 72 publications

Polyols and Polyurethane Foams Based on Water-Soluble Chitosan

Polyols and Polyurethane Foams Based on Water-Soluble Chitosan

Self-assembled amphiphilic chitosan nanoparticles for quercetin delivery to breast cancer cells

Chitosan Based Self-Assembled Nanoparticles in Drug Delivery

Contact Info

Product

Resources

About