Selenium status in patients with Crohn's disease

Rannem, T.; Ladefoged, Karin; Hylander, E.; Hegnhøj, J; Jarnum, S.

doi:10.1093/ajcn/56.5.933

Cited by 57 publications

(17 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…46,47 Importantly, detection of small reserves of selenium in patients with CD has already been reported. [48][49][50] In our study, however, decreased activity of intestinal GPx in inflamed mucosa was not associated with dietary selenium intake and plasmatic selenium concentrations.…”

mentioning

confidence: 59%

Does active Crohn's disease have decreased intestinal antioxidant capacity?

Pinto

Lopes

Bastos

et al. 2013

Journal of Crohn's and Colitis

View full text Add to dashboard Cite

Background and aims: Oxidative stress is presumed to play an important role in Crohn's disease (CD) pathogenesis. Nevertheless, the evaluation of the intestinal antioxidant capacity through the analysis of glutathione peroxidase activity in CD remains to be determined. Methods: 20 CD outpatients and 16 volunteers going through colonic cancer screening were enrolled. Colonoscopy with biopsies was performed in all individuals. Samples from inflamed and non-inflamed mucosa were taken when there was CD endoscopic activity. Spectrophotometric assays were performed to measure tissue glutathione peroxidase (GPx) activity, and total (GSH T ) and oxidized (GSSG) glutathione in all samples. Demographics and clinical characteristics were collected from clinical charts. Results: Inflamed CD mucosa presented reduced GPx activity compared to non-inflamed CD mucosa (42.94 mU/mg protein vs 79.62 mU/mg protein, P b 0.05) and control mucosa (42.94 mU/mg protein vs 95.08 mU/mg protein, P b 0.001). GSH T concentration was reduced in inflamed mucosa when compared to non-inflamed CD mucosa (0.78 μmol/g vs 1.98 μmol/g, P b 0.01) and the control group (0.78 μmol/g vs 2.11 μmol/g, P b 0.001). A significant correlation was detected between GPx activity and GSSG (r = −0.599), disease duration (r = 0.546), and thiopurine treatment (r = −0.480) in non-inflamed CD mucosa. A v a i l a b l e o n l i n e a t w w w . s c i e n c e d i r e c t . c o m ScienceDirectJournal of Crohn's and Colitis (2013) 7, e358-e366Downloaded from https://academic.oup.com/ecco-jcc/article-abstract/7/9/e358/426937 by guest on 07 June 2019Conclusion: Our findings suggest that reduced GPx activity is present in inflamed CD mucosa. In addition, endoscopic activity, disease duration and thiopurine therapy could be associated with mucosal decreased antioxidant activity.

show abstract

mentioning

confidence: 59%

Does active Crohn's disease have decreased intestinal antioxidant capacity?

Pinto

Lopes

Bastos

et al. 2013

Journal of Crohn's and Colitis

View full text Add to dashboard Cite

show abstract

“…Serum selenium concentrations were signi®cantly correlated with the activity of glutathione peroxydase in UC patients, but not in controls. This suggests that the selenium requirement for enzyme activity was met in the majority of the controls and not in the UC patients (Rannem et al, 1992;Thomas et al, 1994). The decrease in serum antioxidants of UC patients may be explained by increased consumption of antioxidants by the recently in¯amed tissue rather than by impaired digestion and absorption of nutrients, which is unlikely in UC patients.…”

Section: Discussionmentioning

confidence: 96%

Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls

et al. 2000

View full text Add to dashboard Cite

Objective: Malnutrition is observed frequently in patients with in¯ammatory bowel disease (IBD). Knowledge of the nutritional status in patients with recently diagnosed IBD is limited. The aim of this study was to establish a comprehensive picture of the nutritional status in recently diagnosed IBD patients. Subjects: Sixty-nine IBD patients (23 Crohn's disease (CD) and 46 with ulcerative colitis (UC)) within 6 months of diagnosis and 69 age-and sex-matched population controls were included in the study. Methods: The nutritional status was assessed by: (1) body composition (anthropometry and dual-energy X-ray absorptiometry); (2) dietary intake (dietary history); (3) biochemical indexes of nutrition; and (4) muscle strength (isokinetic dynamometer). Results: Body weight and body mass index were signi®cantly lower in UC patients compared with controls. The mean daily intake of carbohydrates was signi®cantly higher in CD patients and the intakes of protein, calcium, phosphorus, and ribo¯avin were signi®cantly lower in UC patients compared with controls, respectively. Serum concentrations of several nutrients (b-carotene, magnesium, selenium and zinc) were signi®cantly lower in UC patients compared with controls. Serum vitamin B 12 concentration was signi®cantly lower in CD patients. Muscle strength did not signi®cantly differ between IBD patients and controls.

show abstract

“…This selenium deficiency may lead to a decrease in erythrocyte GPx activity and, presumably through decreased reactive oxygen species scavenging, to enhanced inflammatory and immune mediator transcription caused by nuclear factor ÎB activation [17]. In these patients, a high selenium requirement is probably not only the result of a short bowel as suggested by Rannem et al [18,19]. Our results suggest that sustained inflammation, in particular in patients with active Crohn's disease or radiation enteritis complicated by chronic bacterial overgrowth, may contribute to selenium and consequently selenium-dependent antioxidant system deficiency.…”

Section: Discussionmentioning

confidence: 94%

Home Parenteral Nutrition: Clinical and Laboratory Analysis of Initial Experience (1994–1997)

et al. 1999

View full text Add to dashboard Cite

Background/Aim and Method: Severe malabsorption often necessitates prolonged parenteral nutrition. Home parenteral nutrition (HPN) offers the opportunity for treatment at home. We report clinical and laboratory data of initial 27 HPN patients of one center since its opening in 1994. Results: Clinical and biological markers of nutritional status were normalized and well maintained in most patients. Except for vitamin E and selenium (lower in HPN patients), the other vitamin and micronutrient levels were normal. There was no obvious essential fatty acid deficiency. Cholestasis was usual, but only 1 patient had a severe hepatic disease. Catheter infection occurred 18 times in 13 patients, but the frequency decreased with time (from 4.2 to 1.7 infections/1,000 days on HPN). No patient died from HPN complications. Social rehabilitation and, in some patients, full professional rehabilitation were constant. Conclusions: These data confirm that HPN performed in centers with expertise allowed patients to overcome gut failure and to recover subnormal or normal nutritional status. Satisfactory social rehabilitation was obtained in all patients. HPN complications were rarely life-threatening, and their frequency decreased with experience.

show abstract

Selenium status in patients with Crohn's disease

Cited by 57 publications

References 20 publications

Does active Crohn's disease have decreased intestinal antioxidant capacity?

Does active Crohn's disease have decreased intestinal antioxidant capacity?

Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls

Home Parenteral Nutrition: Clinical and Laboratory Analysis of Initial Experience (1994–1997)

Contact Info

Product

Resources

About