Selenium status during pregnancy and child psychomotor development—Polish Mother and Child Cohort study

Polańska, Kinga; Król, Anna; Sobala, Wojciech; Gromadzińska, Jolanta; Brodzka, Renata; Calamandrei, Gemma; Chiarotti, Flavia; Wąsowicz, Wojciech; Hanke, Wojciech

doi:10.1038/pr.2016.32

Cited by 60 publications

(45 citation statements)

References 33 publications

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“…Median selenium levels in our pregnant population varied from 0.96 µmol/L in week 18 to 0.85 µmol/L in week 36, comparable to reported selenium levels in pregnancy week 15–22 ranging from 0.54 µmol/L in Polish women [6], to 1.25 µmol/L in Spanish women [9], with lower levels observed just before delivery [6,8,9]. The levels increased postpartum, and were higher in regular users of MMN throughout pregnancy and postpartum, as has been observed by others [8], however, almost all (97–99%) values were below 1.57 µmol/L at all time points.…”

Section: Discussionsupporting

confidence: 83%

Impact of Maternal Selenium Status on Infant Outcome during the First 6 Months of Life

et al. 2017

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Pregnant women and infants are at risk for selenium deficiency, which is known to have negative effects on immune and brain function. We have investigated selenium levels in 158 healthy never-pregnant women and in 114 pregnant and lactating women and their infants at age 6 months and related this to clinical outcomes during the first 6 months of life. Neurodevelopment was assessed with the parental questionnaire Ages and Stages (ASQ) at 6 months. A maternal selenium level ≤0.90 µmol/L in pregnancy week 18 was negatively related to infant neurodevelopment at 6 months (B = −20, p = 0.01), whereas a selenium level ≤0.78 µmol/L in pregnancy week 36 was associated with an increased risk (odds ratio 4.8) of having an infant infection during the first 6 weeks of life. A low maternal selenium status in pregnancy was found to be associated with an increased risk of infant infection during the first 6 weeks of life and a lower psychomotor score at 6 months. We suggest a cutoff for maternal serum selenium deficiency of 0.90 µmol/L in pregnancy week 18 and 0.78 µmol/L in pregnancy week 36. This should be reevaluated in an intervention study.

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Section: Discussionsupporting

confidence: 83%

Impact of Maternal Selenium Status on Infant Outcome during the First 6 Months of Life

et al. 2017

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“…12 (±1.5) months. Details regarding child psychomotor assessment have been published before [19][20][21][22][23]. Examination was performed at pediatric medical centers at 2 university hospitals in Łódź and Legnica.…”

Section: Descriptive Analysismentioning

confidence: 99%

“…The covariates considered in the analysis were as follows: maternal age at delivery, pre-pregnancy BMI, weight gain during pregnancy, parental level of education (highest level of completed education), marital status, socioeconomic status, maternal salivary cotinine during pregnancy, child passive smoking status within 1 year after birth (based on maternal smoking status during the first year after delivery and child urinary cotinine at 1 year of age), child gender, birthweight, type of delivery, preterm delivery and child day care attendance. Details regarding the assessment of the variables have been published previously [20][21][22][23].…”

Section: Confounding Variablesmentioning

confidence: 99%

Duration of breastfeeding and psychomotor development in 1-year-old children – Polish Mother and Child Cohort Study

Stelmach

Kwarta

Jerzyńska

et al. 2019

Int J Occup Med Environ Health

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The objective of this study was to evaluate the association between breastfeeding duration and child neurodevelopment based on the Polish Mother and Child Cohort Study. Material and Methods: The current analysis included 501 mother-child pairs. The analysis evaluating the association between the length of breastfeeding and child neurodevelopment considered the following variables: maternal age and body mass index, weight gain during pregnancy, parental level of education, marital status, socioeconomic status, child gender, birthweight, type of delivery, preterm delivery, pre-and postnatal exposure to tobacco constituents and child day care attendance. Psychomotor development was assessed in 1-year-olds on the Bayley Scales of Infant and Toddler Development. Results: The length of breastfeeding correlated positively with maternal age at delivery (ρ = 0.13), maternal and paternal level of education (ρ = 0.2 and ρ = 0.14 respectively), birthweight (ρ = 0.1) and marital status (ρ = 0.16) (p < 0.05). A negative correlation between the length of breastfeeding and maternal smoking status during the first year after delivery (ρ =-0.19) and weight gain during pregnancy (r =-0.1) was observed (p < 0.05). The association between the duration of breastfeeding and child development was not statistically significant in the model with the inclusion of confounding variables. A significant association between language development and maternal level of education (p = 0.004), gender of the child (p = 0.0007) and maternal weight gain during pregnancy (p = 0.01) was found. A negative association between cognitive development and maternal salivary cotinine during pregnancy (p = 0.03) and a negative association between motor development and maternal smoking status during the first year after delivery (p = 0.007) were also found. Conclusions: This study found no significant association between the duration of breastfeeding and child development after adjustment for confounders.

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“…It was established in 2007 with the aim of evaluating the contribution of environmental factors to pregnancy outcomes, children's health and neurodevelopment (Polanska et al 2011). Findings to date suggest that maternal lifestyle, micronutrient and vitamin D status during pregnancy and child environment after birth have significant impacts on child health and psychomotor development (Stelmach et al 2014(Stelmach et al , 2015Polanska et al 2015Polanska et al , 2016.…”

Section: The Polish Mother and Child Cohort (Repro_pl)mentioning

confidence: 99%

Early‐life dietary and epigenetic influences on childhood musculoskeletal health: Update on the UK component of the ALPHABET project

Curtis

Suderman²,

Phillips

et al. 2018

Nutrition Bulletin

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The ALPHABET project, funded through the European Research Area Healthy Diet for a Healthy Life Biomarkers call, aims to expand the knowledge base regarding interactions between diet, epigenetics and offspring health, characterising biomarkers that may inform future health strategies. This review focuses on the UK Biotechnology and Biological Sciences Research Council (BBSRC)‐funded component in which the aim was to (1) generate and collate early‐life epigenetic data and (2) investigate early diet and epigenetic marks as predictors of later bone health. The project builds on a wealth of evidence implicating environmental factors, such as maternal diet and body composition, as influences on the long‐term health and development of the offspring, and that these relationships might be mediated at least in part through epigenetic signals. Experimental studies in animal models have demonstrated that manipulation of maternal diet during pregnancy leads to altered offspring epigenetic marking and phenotype. Human studies convincingly demonstrate associations between early environment and later health and disease for outcomes across musculoskeletal, respiratory, neurodevelopmental and cardiometabolic health. The priority now is to find ways in which such observations can be translated into improved lifelong health. A key approach is to identify early biomarkers of adverse health outcomes and then to test these, and subsequent interventions, in trials aimed at identifying strategies to optimise health throughout the life course. The ALPHABET project will inform this process for musculoskeletal outcomes, and the project as a whole should help elucidate not only novel mechanisms, but also potential strategies to reduce the burden of musculoskeletal, respiratory, neurodevelopmental and cardiometabolic disease in future generations.

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Selenium status during pregnancy and child psychomotor development—Polish Mother and Child Cohort study

Cited by 60 publications

References 33 publications

Impact of Maternal Selenium Status on Infant Outcome during the First 6 Months of Life

Impact of Maternal Selenium Status on Infant Outcome during the First 6 Months of Life

Duration of breastfeeding and psychomotor development in 1-year-old children – Polish Mother and Child Cohort Study

Early‐life dietary and epigenetic influences on childhood musculoskeletal health: Update on the UK component of the ALPHABET project

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