Selenium status and cardiovascular risk factors in healthy Dutch subjects.

Abstract

To provide further insight into the possible role of selenium in cardiovascular disease, we examined the relationship between cardiovascular risk factors, some nutritional parameters, and short- and long-term selenium status. A total of 82 healthy Dutch volunteers, 59 men and 23 women, aged 40-75 years, were studied. Means and standard deviations of selenium parameters were: plasma selenium 106.4 +/- 23.7 micrograms/L, erythrocyte selenium 0.59 +/- 0.19 microgram/g Hb, toenail selenium 0.78 +/- 0.17 ppm, and erythrocyte glutathione peroxidase activity 28.0 +/- 8.1 U/g Hb. No association was found between selenium status and gender, age, serum total-, LDL-, and HDL-cholesterol, systolic and diastolic blood pressure, alcohol intake, and body mass index. A significantly lower plasma selenium level was observed among smokers compared to nonsmokers (101.0 micrograms/L, SE = 3.9 vs 112.0 micrograms/L, SE = 3.6, p = 0.04). A significant negative association was found between erythrocyte selenium and serum levels of vitamin A and ferritin. No relevant relationship was observed between selenium status and serum fatty acid composition, vitamin E, vitamin B6, and iron. Apart from an association between smoking and short-term selenium status, we found no indications that a possible effect of selenium on cardiovascular disease may operate through the known risk factors.

The Relationship between Serum Selenium Levels and Lipid Profiles in Adult Women

“…However, we could not find any associa tion between selenium status and lipid levels when sub jects with low selenium or high selenium levels were excluded in the stepwise analysis for females aged over 40 y (data are not shown). The present result was simi lar to the report of Bukkens et al (54), who found no indications that the possible effect of selenium on CVD may operate through the known CVD risk factors in Dutch people aged 40-75y having similar selenium levels like our subjects aged over 40y. It is well accepted that with advancing age, various lifestyle changes such as physical activity, smoking habits, and administration of estrogen status and its therapy can influence the blood lipid profiles of female adults.…”

Selenium and vitamin status in the Al‐Kharj district, Saudi Arabia

“…There are only a few published studies that can be used for comparison. The mean toenail selenium concentration in the entire population (0.613¡0.217 mg g 21 , range , detection limit 21.797 mg g 21 ) was lower than levels reported by Swanson et al [41] from the USA and Bukkens et al [89] from the Netherlands, although it compares favourably with data from Russia [90] and Greece [91] for both genders. Toenail selenium has been used recently to study the link between selenium deficiency and chronic health conditions such as heart disease and cancer.…”

Plasma Copper, Zinc, and Selenium Levels and Correlates with Metabolic Syndrome Components of Lebanese Adults

“…Furthermore, subjects with low selenium levels were reported to have an increased risk for ischemic heart diseases and myocardial infarction, and this was believed to be the result of a positive association between serum selenium and HDL-C [15,33]. However, others failed to find such an association with HDL-C [34,35] or total cholesterol [34]. A correlation between serum selenium and risk factors for CHD has been reported in adolescents [23], where a positive correlation was found with total cholesterol, HDL-C, non-HDL-C, and DBP.…”