Selenium status and cardiometabolic health: State of the evidence

Stranges, Saverio; Navas‐Acien, Ana; Rayman, Margaret P.; Güallar, Eliseo

doi:10.1016/j.numecd.2010.10.001

Cited by 116 publications

(82 citation statements)

References 83 publications

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“…The impact of Se on immune-related human physiology and pathophysiology is also discussed, with emphasis placed on disorders related to immunity and chronic inflammation. It should be noted that health issues such as hypertension and cardiovascular diseases have been extensively covered in other reviews (141,183,245), and are not included in this article. Finally, issues are raised as to how Se supplementation may be best utilized to enhance or modulate certain types of inflammation and immune responses.…”

Section: Introductionmentioning

confidence: 99%

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

Huang

Rose

Hoffmann

2012

Antioxidants & Redox Signaling

682

496

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Dietary selenium (]Se), mainly through its incorporation into selenoproteins, plays an important role in inflammation and immunity. Adequate levels of Se are important for initiating immunity, but they are also involved in regulating excessive immune responses and chronic inflammation. Evidence has emerged regarding roles for individual selenoproteins in regulating inflammation and immunity, and this has provided important insight into mechanisms by which Se influences these processes. Se deficiency has long been recognized to negatively impact immune cells during activation, differentiation, and proliferation. This is related to increased oxidative stress, but additional functions such as protein folding and calcium flux may also be impaired in immune cells under Se deficient conditions. Supplementing diets with above-adequate levels of Se can also impinge on immune cell function, with some types of inflammation and immunity particularly affected and sexually dimorphic effects of Se levels in some cases. In this comprehensivearticle, the roles of Se and individual selenoproteins in regulating immune cell signaling and function are discussed. Particular emphasis is given to how Se and selenoproteins are linked to redox signaling, oxidative burst, calcium flux, and the subsequent effector functions of immune cells. Data obtained from cell culture and animal models are reviewed and compared with those involving human physiology and pathophysiology, including the effects of Se levels on inflammatory or immune-related diseases including anti-viral immunity, autoimmunity, sepsis, allergic asthma, and chronic inflammatory disorders. Finally, the benefits and potential adverse effects of intervention with Se supplementation for various inflammatory or immune disorders are discussed. Antioxid. Redox Signal. 16, 705-743.

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Section: Introductionmentioning

confidence: 99%

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

Huang

Rose

Hoffmann

2012

Antioxidants & Redox Signaling

682

496

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“…Since that time, cardiometabolic perturbations (insulin resistance, hyperglycemia, hypertension, hypercholesterolemia and cardiovascular diseases) have been associated with supra-nutritional intake of Se in several western populations of Europe and the US, where the use of Se-enriched foods, Se supplements and fertilizers has increased markedly in the last years (reviewed by Stranges et al, 2010). These cardiometabolic changes were observed at serum Se status below 350 μg/L, the minimum Se levels at which selenosis cases from Se supplements have been reported (Schuh and Jappe, 2007).…”

Section: Discussionmentioning

confidence: 99%

No evidence of selenosis from a selenium-rich diet in the Brazilian Amazon

Lemire

Philibert

Fillion

et al. 2012

Environment International

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“…In addition, toxic concentrations of Se cause garlic breath, hair and nail loss, disorders of the nervous system and skin, poor dental health, and paralysis (Rayman., 2012). The use of Se as fertilizers, supplements and in enriched foods, has increased considerably as result of marketing and consumer trends, forgetting that intake of selenium for therapeutic or nutritional purposes should be done under medical supervision (Stranges et al, 2010 ;Nogueira and Rocha, 2011 ).…”

Section: Toxicitymentioning

confidence: 99%