2012
DOI: 10.1016/j.envint.2011.07.005
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No evidence of selenosis from a selenium-rich diet in the Brazilian Amazon

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Cited by 56 publications
(30 citation statements)
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“…Selenium in Brazil nuts is found in selenomethionine and selenocysteine species, and studies show that selenomethionine concentration ranges from 75 to 90 % [46,47]. Despite high selenium content in Brazil nuts, no participants complained of symptoms associated with selenosis, as observed by Lemire et al [48]. The lack of toxicity occurs because selenomethionine, which presents high bioavailability, either can be reduced to hydrogen selenide for selenoprotein synthesis, or can nonspecifically replace methionine in proteins of plasma and blood [45,49].…”
Section: Discussionmentioning
confidence: 62%
“…Selenium in Brazil nuts is found in selenomethionine and selenocysteine species, and studies show that selenomethionine concentration ranges from 75 to 90 % [46,47]. Despite high selenium content in Brazil nuts, no participants complained of symptoms associated with selenosis, as observed by Lemire et al [48]. The lack of toxicity occurs because selenomethionine, which presents high bioavailability, either can be reduced to hydrogen selenide for selenoprotein synthesis, or can nonspecifically replace methionine in proteins of plasma and blood [45,49].…”
Section: Discussionmentioning
confidence: 62%
“…However, more recent studies suggest that the organic forms of Se found in food may be less toxic than those found in occupational settings, nutritional supplements or drinking water (Rayman, 2012). Indeed, no evidence of selenium toxicity was found in the Brazilian Amazon, a fish-eating population with blood Se status at times surpassing 1000 μg/L (Lemire et al, 2006;Lemire et al, 2012). In Northern and Amazonian populations highly exposed to MeHg, high Se intake may partially offset MeHg-mediated oxidative stress and/or be required to maintain optimal Se-enzyme levels.…”
Section: All (N = 702)mentioning
confidence: 93%
“…effects of higher Se levels on motor performance [46] and reduced risk for cataracts [47], Se toxicity may be associated with longer-term disturbances, such as diabetes and cardiovascular disease [2,41,48], and further study is warranted to fully establish the long-term safety of Se supplementation through diet. • Brazil nuts can be used as a dietary selenium supplement.…”
Section: A C C E P T E D Accepted Manuscriptmentioning
confidence: 99%
“…In the present work, different biomarkers were used to cover different periods of Se exposure: plasma and urine were used as markers of current exposure; erythrocytes reflect longer-term nutritional status, due to their half-life of 120 d; and nails and hair were useful as long-term biomarkers and reflect tissue Se levels [1,[34][35][36] [38,41]. A doctor clinically evaluated the children in our study, but no signs of selenosis were observed in both groups, consistent with other studies of Amazon populations [31,41].…”
Section: A C C E P T E D Accepted Manuscriptmentioning
confidence: 99%