Selenium-Rich Yeast Protects Against Aluminum-Induced Renal Inflammation and Ionic Disturbances

Abstract

The aim of this study was to evaluate the protective effects of SeY (selenium-rich yeast) against Al (aluminum)-induced inflammation and ionic imbalances. Male Kunming mice were treated with Al (10 mg/kg) and/or SeY (0.1 mg/kg) by oral gavage for 28 days. The degree of inflammation was assessed by mRNA expression of inflammatory biomarkers. Ionic disorders were assessed by determining the Na, K, and Ca content, as well as the alteration in ATP-modifying enzymes (ATPases), including NaK-ATPase, Ca-ATPase, Mg-ATPase, CaMg-ATPase, and the mRNA levels of ATPase's subunits in kidney. It was observed here that SeY exhibited a significant protective effect on the kidney against the Al-induced upregulation of pro-inflammatory and downregulation of anti-inflammatory cytokines. Furthermore, a significant effect of Al on the Na, K, Ca, and Mg levels in kidney was observed, and Al was observed to decrease the activities of NaK-ATPase, Mg-ATPase, and CaMg-ATPase. The mRNA expression of the NaK-ATPase subunits and Ca-ATPase subunits was regulated significantly by Al. Notably, SeY modulated the Al-induced alterations of ion concentrations, ATPase activity, and mRNA expression of their subunits. These results suggest that SeY prevents renal toxicity caused by Al via regulation of inflammatory responses, ATPase activities, and transcription of their subunits.

Benefits and risks of essential trace elements in chronic kidney disease: a narrative review

“…Moreover, Se supplementation in chronic inflammation restores depleted hepatic and serum levels by increasing selenoprotein biosynthesis, leading to suppressed C-reactive protein production and attenuating the inflammatory process ( 134 ). The toxic effects of aluminum in patients with advanced CKD are expressed by severe encephalopathy and bone disease ( 135 ), and experiment on mice found Se-rich yeast (SeY) prevented renal toxicity caused by aluminum via regulation of inflammatory responses, ATPase activities, and transcription of their subunits ( 136 ). DNA damage in white blood cells is higher in CKD patients on HD than in healthy controls, and Se supplementation prevents the damage to DNA ( 137 ).…”

IP3R and RyR channels are involved in traffic-related PM2.5-induced disorders of calcium homeostasis

“…A relevant study described that the Ca 2+ -Mg 2+ -ATPase activity decreased with the elevated Pb + , Na + , and Ca 2+ concentrations in the cells (Sun et al, 2007). Recent study shows that exposure to Al causes the decrease of Ca 2+ -Mg 2+ -ATPase activity, which leaving Ca 2+ -Mg 2+ -ATPase unable to keep up with the Ca 2+ transport needs and further aggravating Ca 2+ overload (Cao et al, 2018). Previous report also indicates that Ca 2+ overload disrupts the structure and function of mitochondria, impedes cellular energy metabolism, and reduces ATP production (Zhu et al, 1995).…”