Ameliorating effects of Rhamnus alaternus L. aqueous extract on aluminum chloride-induced nephrotoxicity via attenuation of oxidative stress in male Wistar rats

Tichati, Lazhari; Benzaid, Chahrazed; Trea, Fouzia; Rouabhia, Mahmoud; Ouali, Kheireddine

doi:10.1007/s00580-022-03405-6

Cited by 4 publications

(5 citation statements)

References 39 publications

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“…Additionally, renal tubules with wide lumen, deteriorated epithelium and congested renal blood vessels were observed. Similar observations of degenerative changes in renal tissues of AlCl 3 ‐intoxicated animals were reported 5,66,103 …”

Section: Discussionsupporting

confidence: 82%

“…Similar observations of degenerative changes in renal tissues of AlCl 3 -intoxicated animals were reported. 5,66,103 In contrast, SM and its nanoparticles notably declined the harmful influences of AlCl 3 on hematological parameters. Additionally, their administration protects the kidney damaged by AlCl 3 -intoxication as shown by a considerable restoration of serum urea, creatinine, and uric acid levels.…”

Section: Discussionmentioning

confidence: 93%

“…Al is an industrial and environmental contaminant that causes a wide range of toxicity. Exposure to high Al levels leads to hepatotoxicity, cardiotoxicity, 2 neurotoxicity, hematotoxicity, 3 lung damage, 4 and nephrotoxicity 5 . Additionally, Al compounds can bind with RNA and DNA and prohibit vital enzymes including hexokinase, alkaline phosphatase (ALP), phosphooxidase, and phosphodiesterase 6 .…”

Section: Introductionmentioning

confidence: 99%

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Nephroprotective effects of silymarin and its fabricated nanoparticles against aluminum‐induced oxidative stress, hyperlipidemia, and genotoxicity

El‐Demerdash,

Ahmed,

El‐Sayed

et al. 2024

Environmental Toxicology

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BackgroundAluminum (Al) is a ubiquitous element with proven nephrotoxicity. Silymarin (SM) is a mixture of polyphenolic components extracted from Silybum marianum and exhibited protective influences. However, SM bioactivity can be enhanced by its incorporation in chitosan (CS) through the use of nanotechnology. This work proposed to assess the protective influence of SM and its loaded chitosan nanoparticles (SM‐CS‐NPs) on aluminum chloride (AlCl3)‐induced nephrotoxicity.MethodsSix groups were created randomly from 42 male Wistar rats and each one contains 7 rats (n = 7). Group I, acted as a control and received water. Group II received SM (15 mg/kg/day) and group III administered with SM‐CS‐NPs (15 mg/kg/day). Group IV received AlCl3 (34 mg/kg) and groups V and VI were treated with SM and SM‐CS‐NPs with AlCl3 respectively for 30 days.ResultsAlCl3 administration significantly elevated TBARS, H2O2, and kidney function levels besides LDH activity. Whereas GSH, CAT, SOD, GPx, GST, and GR values were all substantially reduced along with protein content, and ALP activity. Additionally, significant alterations in lipid profile, hematological parameters, and renal architecture were observed. Moreover, TNF‐α, TGF‐β, and MMP9 gene expression were upregulated in kidney tissues. The administration of SM or its nanoparticles followed by AlCl3 intoxication attenuated renal dysfunction replenished the antioxidant system, and downregulated TNF‐α, TGF‐β, and MMP9 gene expression in renal tissues compared to the AlCl3 group.ConclusionSM‐CS‐NPs have more pronounced appreciated protective effects than SM and have the proficiency to balance oxidant/antioxidant systems in addition to their anti‐inflammatory effect against AlCl3 toxicity.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Nephroprotective effects of silymarin and its fabricated nanoparticles against aluminum‐induced oxidative stress, hyperlipidemia, and genotoxicity

El‐Demerdash,

Ahmed,

El‐Sayed

et al. 2024

Environmental Toxicology

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“…We observed that MDA, Caspase-3, and TNF-α levels increased in the Alu group compared to the control. It was seen that MDA levels increased while antioxidant enzyme levels decreased in the Alu group and it was reported that the antioxidant Rhamnus aternus L. extract protects the tissue by increasing antioxidant enzyme levels (Tichati et al, 2022). Othman et al (2020) determined that lipid peroxidation and nitric oxide and TNF-α levels increased while glutathione decreased in rats' liver and kidney tissues treated with Alu.…”

Section: Discussionmentioning

confidence: 94%

Alüminyuma Maruz Kalan Sıçanların Böbreklerinde 3-Benzoil-7-Hidroksi Kumarin Bileşiğinin TNF-α ve Kaspaz-3 İmmün Reaktivitesi Üzerine Etkileri

TÜRK,

KULOĞLU,

ZENCİRCİ

et al. 2023

Comm. J. Biol.

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In this study, we aimed to investigate the effects of 3-benzoyl-7-hydroxy coumarin compound on apoptotic markers in the kidney tissues of rats treated with Aluminum(Alu). 28 Wistar albino male rats were divided into four groups (n = 7) as: Control Group: 1 ml/kg 0.9% NaCl was administered by oral gavage every other day during the experiment. Aluminium (Alu) Group: Alu was prepared in water and given by intraperitoneal(i.p) for 30 days at an excess of 8.3 mg/kg/day. Treatment Group: 10 mg/kg 3-Benzoyl-7-Hydroxy Coumarin was administered to rats by oral gavage every other day for 30 days. Alu + Treatment Group: 8.3 mg/kg Alu was prepared in water and administered i.p for 30 days every other day, and then 10 mg/kg 3-Benzoyl-7-Hydroxy Coumarin was administered to rats by oral gavage every other day for 30 days. At the end of the 30-day experiment, the kidney tissue of the animals were removed under anesthesia and stored under appropriate conditions. In according to our data, Alu administration caused increased Caspase-3 TNF-α and MDA levels in kidney tissue, and 3-benzoyl-7-hydroxy coumarin was found to significantly reverse these changes.

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“…In addition, Al disrupts mitochondrial function, resulting in the excessive generation of highly reactive free radicals/electrophiles [ 9 ]. These ROS can further damage cellular constituents such as lipids, proteins, and DNA, and interfere with the redox regulatory system [ 10 ]. However, recent studies suggest that neutralizing ROS is a crucial strategy in preventing or impeding the progression of pathological processes associated with Al exposure [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Nephroprotective Effects of Caffeine, Vanillin, and Their Combination against Experimental AlCl3-Induced Renal Toxicity in Adult Male Wistar Rats

Afolabi,

Olasehinde,

Olaoye

et al. 2023

Biochemistry Research International

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Aluminum (Al) is known to be a nephrotoxic metal that can cause renal toxicity in both humans and animals. The use of functional foods has been reported to have significance in managing the toxic effects associated with such metals. This study aimed to assess the potential protective effects of caffeine, vanillin, and their combination in mitigating AlCl3-induced renal toxicity in adult male Wistar rats. A total of thirty (30) adult male Wistar rats weighing between 150 and 200 g were randomly divided into five groups, each consisting of six rats (n = 6). Group 1 served as the control, while the remaining treatment groups received a daily oral dose of 100 mg/kg AlCl3 for a duration of 21 days. In addition, groups 3–5 were coadministered 50 mg/kg body weight (bw) of caffeine, vanillin, and a combination (50/50 mg/kg bw) of both substances, respectively. In the results, AlCl3-treated showed a significant ( p < 0.05) increase in serum biomarkers such as ALT, ALP, urea, and creatinine, and a significant ( p < 0.05) decrease in serum total proteins (TPs). The renal tissue’s antioxidant system, including SOD, CAT, GPx, and GSH, exhibited a significant ( p < 0.05) reduction, accompanied by an elevated MDA level. However, the administration of caffeine, vanillin, and their combination resulted in a significant ( p < 0.05) decrease in serum ALT, ALP, urea, and creatinine, and a significant ( p < 0.05) increase in serum TP. Furthermore, following the treatment, there was a significant ( p < 0.05) increase in renal SOD, CAT, GPx, and GSH levels, along with a reduction in the MDA level. In addition, the treatment for 21 days caused a significant ( p < 0.05) reversal to the altered histomorphological architecture. These findings suggest that caffeine, vanillin, and their combination could potentially be an effective regimen in managing AlCl3-induced renal toxicity.

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Ameliorating effects of Rhamnus alaternus L. aqueous extract on aluminum chloride-induced nephrotoxicity via attenuation of oxidative stress in male Wistar rats

Cited by 4 publications

References 39 publications

Nephroprotective effects of silymarin and its fabricated nanoparticles against aluminum‐induced oxidative stress, hyperlipidemia, and genotoxicity

Nephroprotective effects of silymarin and its fabricated nanoparticles against aluminum‐induced oxidative stress, hyperlipidemia, and genotoxicity

Alüminyuma Maruz Kalan Sıçanların Böbreklerinde 3-Benzoil-7-Hidroksi Kumarin Bileşiğinin TNF-α ve Kaspaz-3 İmmün Reaktivitesi Üzerine Etkileri

Nephroprotective Effects of Caffeine, Vanillin, and Their Combination against Experimental AlCl3-Induced Renal Toxicity in Adult Male Wistar Rats

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