Selenium preserves keratinocyte stemness and delays senescence by maintaining epidermal adhesion

Jobeili, Lara; Rousselle, Patricia; Béal, David; Blouin, Eric; Roussel, Anne‐Marie; Damour, O.; Rachidi, Walid

doi:10.18632/aging.101322

Cited by 30 publications

(29 citation statements)

References 46 publications

(54 reference statements)

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“…This is in agreement with the study conducted in Isfahan in 1998 that found that basel cell carcinoma could be accounted for about 74% of skin cancers (23). Skin could be exposed to ecological issues such as pollutants, chemicals, and ultra violet exposure, which can induce untimely skin aging and increase the risk of skin cancer (7). Thus, further study toward these directions, seem to be advantageous in Iranian population with skin cancer.…”

Section: Discussionsupporting

confidence: 89%

“…Antioxidants molecules could also reduce the effect of oxidative stress in such events. Selenoproteins, endogenous antioxidants, could reduce this effect by a defending role (7). The investigation based on a retrospective chart review on 656 patients highlighted an increased incidence of non-melanoma skin cancer in 1.4%, particularly in the 50 -64 age range (2.8%) when compared with the general United States population (0.65% -1.05%) (8).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Skin Cancer in Isfahan Province, Iran

Tolou-Ghamari

2018

Jentashapir J Health Res

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Background:Internationally previous publications confirmed that skin cancer could be categorized as one of the most common cancer among others. Objectives: This study aimed to investigate skin cancer crude rate and incidence in Isfahan Province, Iran. Methods: Data (2011Data ( -2015 was collected from the Isfahan Cancer Registry. The skin cancer was defined by topography code C43 and C44. Period prevalence and incidence was calculated per 100 000 persons. Results: There were 3837 patients that corresponded to a period prevalence of 77.1. With a minimum of 5 and a maximum of 103, skin cancer in 67% was defined at the age between 60 and 70 years. Malignant melanoma of skin was reported in 8 out of total population in which all died from it at the age between 42 to 95 years. There was an increase in incidence from 17.4 to 22.3, in which the mean incidence in males (24) was significantly higher (P < 0.001) than females (14.3). Conclusions: In total population there was death-reported-data in 2% of patients with skin cancer. A 28.2% increase in incidence and 69.1% higher crude rate of males (96.2) versus females (56.9), which recommends further research in this direction.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Prevalence of Skin Cancer in Isfahan Province, Iran

Tolou-Ghamari

2018

Jentashapir J Health Res

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“…First of all and in order to select the optimal concentration of SS to be included in our culture condition, we showed that SS is well tolerated by keratinocytes below 500 nM concentrations. This result is consistent with several studies showing that there is no toxicity observed in several primary or transformed cell lines treated with a range of SS concentrations below 500 nM [ 25 , 26 ]. However, higher concentrations of SS showed high toxicity in several cell lines (e.g., IC50 of sodium selenite 2.3 μ M on HaCat cell line).…”

Section: Discussionsupporting

confidence: 93%

Age-Dependent Protective Effect of Selenium against UVA Irradiation in Primary Human Keratinocytes and the Associated DNA Repair Signature

Favrot

Béal

Blouin

et al. 2018

Oxidative Medicine and Cellular Longevity

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Few studies have focused on the protective role of selenium (Se) against skin aging and photoaging even though selenoproteins are essential for keratinocyte function and skin development. To the best of our knowledge, the impact of Se supplementation on skin cells from elderly and young donors has not been reported. Therefore, the main objective of our study was to evaluate the effects of Se supplementation on skin keratinocytes at baseline and after exposure to ultraviolet A (UVA) irradiation. Low doses of Se (30 nM) were very potently protective against UVA-induced cytotoxicity in young keratinocytes, whereas the protection efficiency of Se in old keratinocytes required higher concentrations (240 nM). Additionally, the DNA repair ability of the old keratinocytes drastically decreased compared with that of the young keratinocytes at baseline and after the UVA exposure. The Se supplementation significantly enhanced the DNA repair of 8-oxoguanine (8oxoG) only in the keratinocytes isolated from young donors. Therefore, aged keratinocytes have an increased vulnerability to oxidative DNA damage, and the Se needs in the elderly should be considered. Strengthening DNA repair activities with Se supplementation may represent a new strategy to combat aging and skin photoaging.

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“…Low doses of Se were very potently protective against UVA-induced cytotoxicity in young keratinocytes, whereas the aged keratinocytes require four times more Se than the young keratinocytes to be protected from UVA-induced cytotoxicity [218,219]. Se protects keratinocyte stem cells (KSCs) against senescence via preservation of their stemness phenotype through adhesion to the basement membrane [219]. showed that Vitamin C (250 mg/kg), vitamin E (250 mg/kg) and Se (0.2mg/kg) exerted antioxidant effects and consequently may prevent skin damage caused by streptozotocininduced diabetes (65 mg/kg) in Swiss albino rats [220].…”

Section: Colostrummentioning

confidence: 99%

Skin Aging & Modern Age Anti-aging Strategies

Mohiuddin¹

2019

GJMR

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As the most voluminous organ of the body that is exposed to the outer environment, the skin suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features such as wrinkling, loss of elasticity, laxity, and rough-textured appearance. This aging process is accompanied with phenotypic changes in cutaneous cells as well as structural and functional changes in extracellular matrix components such as collagens and elastin. With intrinsic aging, structural changes occur in the skin as a natural consequence of the biological changes over time and produce a certain number of histological, physiological, and biochemical modifications. Intrinsic aging is determined genetically (influence of gender and ethnic group), variable in function of skin site, and also influenced by hormonal changes. Visually it is characterized by fine wrinkles. By comparison, “photoaging” is the term used to describe the changes occurring in the skin, resulting from repetitive exposure to sunlight. The histological, physiological, and biochemical changes in the different layers of the skin are much more drastic. From a mechanical point of view, human skin appears as a layered composite containing the stiff thin cover layer presented by the stratum corneum, below which are the more compliant layers of viable epidermis and dermis and further below the much more compliant adjacent layer of subcutaneous white adipose tissue.

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Selenium preserves keratinocyte stemness and delays senescence by maintaining epidermal adhesion

Cited by 30 publications

References 46 publications

Prevalence of Skin Cancer in Isfahan Province, Iran

Prevalence of Skin Cancer in Isfahan Province, Iran

Age-Dependent Protective Effect of Selenium against UVA Irradiation in Primary Human Keratinocytes and the Associated DNA Repair Signature

Skin Aging & Modern Age Anti-aging Strategies

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