Selenium Nanoparticles: Potential in Cancer Gene and Drug Delivery

Maiyo, Fiona; Singh, Moganavelli

doi:10.2217/nnm-2017-0024

Cited by 185 publications

(144 citation statements)

References 80 publications

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“…The major antioxidant effect of selenium is mediated through activation and stimulation of antioxidant defense enzymes, especially GSH and GPx. In recent years, colloidal selenium nanoparticles have been proposed for use as a chemotherapy agent . Some selenium compounds such as CysSeSeCys and Se‐methylselenocysteine (SMC) have shown dual functions as both antioxidant and pro‐oxidant agents .…”

Section: Selenium Compounds and Their Effectsmentioning

confidence: 99%

“…In recent years, colloidal selenium nanoparticles have been proposed for use as a chemotherapy agent. 29 Some selenium compounds such as CysSeSeCys and Se-methylselenocysteine (SMC) have shown dual functions as both antioxidant and pro-oxidant agents. 30 It has been reported that these compounds may be useful as chemotherapy adjuvants for treatment and better control of tumors.…”

Section: And Their Effectsmentioning

confidence: 99%

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Selenium as an adjuvant for modification of radiation response

Farhood

Mortezaee

Motevaseli

et al. 2019

J of Cellular Biochemistry

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Ionizing radiation plays a central role in several medical and industrial purposes. In spite of the beneficial effects of ionizing radiation, there are some concerns related to accidental exposure that could pose a threat to the lives of exposed people. This issue is also very critical for triage of injured people in a possible terror event or nuclear disaster. The most common side effects of ionizing radiation are experienced in cancer patients who had undergone radiotherapy. For complete eradication of tumors, there is a need for high doses of ionizing radiation. However, these high doses lead to severe toxicities in adjacent organs. Management of normal tissue toxicity may be achieved via modulation of radiation responses in both normal and malignant cells. It has been suggested that treatment of patients with some adjuvant agents may be useful for amelioration of radiation toxicity or sensitization of tumor cells. However, there are always some concerns for possible severe toxicities and protection of tumor cells, which in turn affect radiotherapy outcomes. Selenium is a trace element in the body that has shown potent antioxidant and radioprotective effects for many years. Selenium can potently stimulate antioxidant defense of cells, especially via upregulation of glutathione (GSH) level and glutathione peroxidase activity. Some studies in recent years have shown that selenium is able to mitigate radiation toxicity when administered after exposure. These studies suggest that selenium may be a useful radiomitigator for an accidental radiation event. Molecular and cellular studies have revealed that selenium protects different normal cells against radiation, while it may sensitize tumor cells. These differential effects of selenium have also been revealed in some clinical studies. In the present study, we aimed to review the radiomitigative and radioprotective effects of selenium on normal cells/tissues, as well as its radiosensitive effect on cancer cells.

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Section: Selenium Compounds and Their Effectsmentioning

confidence: 99%

Section: And Their Effectsmentioning

confidence: 99%

Selenium as an adjuvant for modification of radiation response

Farhood

Mortezaee

Motevaseli

et al. 2019

J of Cellular Biochemistry

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“…13 Additionally, numerous studies have declared its chemopreventive and therapeutic activity against various types of cancers. [14][15][16][17] ALG is a natural ionic polymer with l-guluronate and d-mannuronate as major components. It is typically extracted from brown algae (Phaeophyceae).…”

Section: Introductionmentioning

confidence: 99%

Fabrication and physicochemical characterization of porous composite microgranules with selenium oxyanions and risedronate sodium for potential applications in bone tumors

Kolmas

Pajor

Pajchel

et al. 2017

IJN

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Nanocrystalline hydroxyapatite containing selenite ions (SeHA; 9.6 wt.% of selenium) was synthesized using wet method and subject to careful physicochemical analysis by powder X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, solid-state nuclear magnetic resonance, wavelength dispersive X-ray fluorescence, and inductively coupled plasma optical emission spectrometry. SeHA was then used to develop the selenium-containing hydroxyapatite/alginate (SeHA/ALG) composite granules. Risedronate sodium (RIS) was introduced to the obtained spherical microgranules of a size of about 1.1–1.5 mm in 2 ways: during the granules’ preparation (RIS solution added to a suspension of ALG and SeHA), and as a result of SeHA/ALG granules soaking in aqueous RIS solution. The analysis made using 13 C and 31 P cross-polarization magic angle spinning nuclear magnetic resonance confirmed the presence of RIS and its interaction with calcium ions. Then, the release of selenium (inductively coupled plasma optical emission spectrometry) and RIS (high-performance liquid chromatography) from microgranules was examined. Moreover, cytotoxicity of fabricated granules was assessed by MTT test. Selenium release was biphasic: the first stage was short and ascribed to a “burst release” probably from a hydrated surface layer of SeHA crystals, while the next stage was significantly longer and ascribed to a sustained release of selenium from the crystals’ interior. The study showed that the method of obtaining microgranules containing RIS significantly affects its release profile. Performed cytotoxicity test revealed that fabricated granules had high antitumor activity against osteosarcoma cells. However, because of the “burst release” of selenium during the first 10 h, the granules significantly reduced viability of normal osteoblasts as well.

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“…Selenium (Se) is an essential trace element in the human body with physiological functions and extensive pharmacological effects. For instance, Se enhances the ability of immune systems to recognize viruses, foreign bodies, and diseases in the body, improving immune function 104. Recently, researchers have attracted more and more attention on SeNPs compared with inorganic or organic selenium due to their better oxidation resistance and low toxicity 57.…”

Section: Nanotherapeutics Of Ra Based On Nanodrugsmentioning

confidence: 99%

“…For instance, Se enhances the ability of immune systems to recognize viruses, foreign bodies, and diseases in the body, improving immune function. [104] Recently, researchers have attracted more and more attention on SeNPs compared with inorganic or organic selenium due to their better oxidation resistance and low toxicity. [57] SeNPs have been reported to be used as a carrier for antitumor and Alzheimer's disease therapeutics.…”

Section: Antiangiogenesis Therapymentioning

confidence: 99%

Recent Advances in Nanotheranostics for Treat‐to‐Target of Rheumatoid Arthritis

Wang

Meng

et al. 2020

Adv Healthcare Materials

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Early diagnosis, standardized treatment, and regular monitoring are the clinical treatment principle of rheumatoid arthritis (RA). The overarching principles and recommendations of treat‐to‐target (T2T) in RA advocate remission as the optimum aim, especially for patients with very early disease who are initiating therapy with anti‐RA medications. However, traditional anti‐RA drugs cannot selectively target the inflammatory areas and may cause serious side effects due to its short biological half‐life and poor bioavailability. These limitations have significantly driven the research and application of nanomaterial‐based drugs in theranostics of RA. Nanomedicines have appropriate sizes and easily modified surfaces which can enhance their biological compatibility and prolong circulation time of drug‐loading systems in vivo. Traditional T2T regimens cannot evaluate the efficacy of drugs in real time, while clinical drug nanosizing can realize the integration of diagnosis and treatment of RA. This review bridges clinically proposed T2T concepts and nanomedicine in an integrated system for RA early‐stage diagnosis and treatment. The most advanced progress in various nanodrug delivery systems for theranostics of RA is summarized, establishing a clear path and a new perspective for further optimization of T2T. Finally, the key facing challenges are discussed and prospects are addressed.

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Selenium Nanoparticles: Potential in Cancer Gene and Drug Delivery

Cited by 185 publications

References 80 publications

Selenium as an adjuvant for modification of radiation response

Selenium as an adjuvant for modification of radiation response

Fabrication and physicochemical characterization of porous composite microgranules with selenium oxyanions and risedronate sodium for potential applications in bone tumors

Recent Advances in Nanotheranostics for Treat‐to‐Target of Rheumatoid Arthritis

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