Selenium nanoparticles and quercetin suppress thioacetamide‐induced hepatocellular carcinoma in rats: Attenuation of inflammation involvement

Abstract

The current study investigates the anti-inflammatory and hepatoprotective effects of selenium (Se) formulated as nanoparticles (SeNPs) and in combination with quercetin (QCT) against thioacetamide (TAA)-induced hepatocellular carcinoma (HCC) in rats. Seventy-two male Sprague-Dawley rats were divided into six groups (n = 12). Three control groups; normal, SeNPs; group received SeNPs only and HCC; group received TAA. In addition, three preventive groups; SeNPs + TAA, QCT + TAA, and QCT + SeNPs + TAA. Induction of HCC was detected histopathologically and by the raise of the serum level of alpha-fetoprotein (AFP). Oxidative stress was evaluated by the hepatic levels of reduced glutathione (GSH), glutathione peroxidase (GPx), and malondialdehyde (MDA) spectrophotometrically. The oncogenic pathway of p53/β-catenin/cyclin D1 was assessed by immunohistochemistry. The inflammatory markers; interleukin-33 (IL-33), IL-6, and IL-1β were assessed by enzyme-linked immune sorbent assay. SeNPs prevented the elevation of serum AFP and hepatic IL-33, IL-1β, and IL-6 in comparison to HCC or QCT + TAA groups.SeNPs + TAA exhibited a lower positive hepatic staining of p53, β-catenin, and cyclin D1 in comparison to HCC or QCT + TAA groups. Moreover, SeNPs improved the overall oxidative balance indicated by low hepatic MDA and enhanced GSH and GPx when compared to HCC or QCT + TAA groups. SeNPs alone and in combination with QCT were found to suppress the progression of HCC in rats via the enhancement of the oxidative stress and then inflammatory status and the prevention of the deregulation of the oncogenic axis pathway of p53/β-catenin/cyclin D.

Simvastatin Induces Apoptosis And Suppresses Hepatocellular Carcinoma Induced In Rats

“…The significant high levels of AFP are usually related to poor differentiation and biologically malignant characteristics especially portal vein invasion of HCC [ 66 , 67 ]. In the current study, serum AFP concentration was significantly elevated in the HCC group as compared to the control group, in agreement with [ 47 , 48 , 57 , 60 ] who reported that AFP concentration was significantly increased in TAA-induced HCC rats. The SV group exhibited lower serum AFP levels ( p < 0.0001), increasing the probability of better prognosis of HCC.…”

The advance anticancer role of polymeric core‐shell ZnO nanoparticles containing oxaliplatin in colorectal cancer

“…Additionally, they can be designed for tracking and monitoring purposes and to slow drug release. [ 1–9 ] Polymeric nanocomposites are a new branch of biomaterials that have attracted much attention in pharmacy and medicine. Polymeric nanocomposites may be made of various nanoparticles such as ceramics, metals, metal oxides, and clays scattered in a polymeric matrix.…”

Triple Cross‐linked Dynamic Responsive Hydrogel Loaded with Selenium Nanoparticles for Modulating the Inflammatory Microenvironment via PI3K/Akt/NF‐κB and MAPK Signaling Pathways

“…[31] Selenium nanoparticles (SeNPs) have received extensive attention due to their excellent biocompatibility, antibacterial, antiviral, and anticancer activities, and notable antioxidant and anti-inflammatory properties. [32][33][34][35][36][37] SeNPs triggers intracellular ROS overproduc-tion to induce cell and bacterial apoptosis. Nevertheless, SeNPs have significantly emerged with pro-oxidant and antioxidant potential dependent on subsequent duration, dose, frequency, and oxidation state.…”