Selenium in serum and whole blood in patients with surgical interventions

Winnefeld, K; Dawczynski, H; Schirrmeister, W; Adam, Gerhard; Friedrich, Ursula; Hein, Stefan

doi:10.1007/bf02789417

Cited by 14 publications

(13 citation statements)

References 2 publications

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“…Our study showed that the levels of Se in the plasma decreased after the total knee arthroplasty. This result is in agreement with previous studies [21][22][23]. To induce selenoenzymes, Se is required and incorporated into the enzymes as Sec.…”

Section: Discussionsupporting

confidence: 95%

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Acute Phase Response of Selenium Status and Glutathione Peroxidase Activity in Blood Plasma Before and After Total Knee Arthroplasty Surgery

Defi

Yamazaki

Kameo

et al. 2011

Biol Trace Elem Res

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Several studies show the consistent results of the decrease in plasma or serum selenium (Se) after surgery, and the change is suggested to be a negative acute phase response of Se to the surgical inflammation. Plasma glutathione peroxidase (GPx), which is included in the acute phase response proteins, is a selenoenzyme. However, previous studies failed to show any changes in GPx activity before and after surgery. In the present study, we investigated the Se- and selenoenzyme responses that accompany the acute inflammatory reactions during and following major surgery. Patients who underwent elective total knee arthroplasty surgery due to knee osteoarthritis at the Department of Orthopaedic Surgery at Gunma University Hospital in Japan were studied. The plasma Se concentration was determined, and the activity of plasma GPx was measured. C-reactive protein (CRP), albumin, blood urea nitrogen (BUN), and white blood cell (WBC) count were also analysed. Increases in the inflammatory biomarkers of CRP and WBC showed inflammatory reactions with the surgery. A significant increase in plasma GPx activity (p < 0.05) and decreases in the plasma Se concentration (p < 0.05) and in serum albumin (p < 0.05) after surgery were observed. Since albumin is a Se-containing protein and represents a negative acute phase protein that provides amino acids for the production of other series of acute phase proteins, the present results suggest that there is a redistribution of plasma Se to GPx that occurs as an acute phase response, and the source of Se for GPx could be, at least partly, from albumin.

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Section: Discussionsupporting

confidence: 95%

“…Consistent results of decrease in plasma or serum Se after surgery have been obtained in several previous studies [21][22][23]. However, the acute response of Se and selenoenzyme metabolism due to surgery has not been fully elucidated.…”

Section: Introductionsupporting

confidence: 72%

Acute Phase Response of Selenium Status and Glutathione Peroxidase Activity in Blood Plasma Before and After Total Knee Arthroplasty Surgery

Defi

Yamazaki

Kameo

et al. 2011

Biol Trace Elem Res

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show abstract

“…Measurements were taken using automated graphite furnace atomic absorption spectrophotometry. For the comparison of WBSL, we used the recommended normal range of 85 Á 162 mg/l [31]. This normal range comes from the University of Jena (Thuringia), and we can use it for the entirety of Germany, because we believe there is not a substantial variation of diet among German people.…”

Section: Methodsmentioning

confidence: 99%

Whole blood selenium levels (WBSL) in patients with prostate cancer (PC), benign prostatic hyperplasia (BPH) and healthy male inhabitants (HMI) and prostatic tissue selenium levels (PTSL) in patients with PC and BPH

et al. 2009

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“…The blood analyses were conducted in the biosyn laboratory, Fellbach, Germany. Based on measurements in healthy individuals, the reference range for optimal or suboptimal values was 89-168 µg/l [35]. The selenium values were correlated with patient-(age, gender), tumor-(diagnosis, stage) and treatment-related parameters (radiation dose, treated volume, anatomic site).…”

Section: Methodsmentioning

confidence: 99%

“…51 patients (23%) showed selenium concentrations within the reference range ("optimal" or "suboptimal" levels) between 89 µg/l and 168 µg/l [35]. 170 patients (77%) had decreased selenium values < 89 µg/l.…”

Section: Selenium Valuesmentioning

confidence: 99%