Acute Phase Response of Selenium Status and Glutathione Peroxidase Activity in Blood Plasma Before and After Total Knee Arthroplasty Surgery

Defi, Irma Ruslina; Yamazaki, Chiho; Kameo, Satomi; Kobayashi, Kenji; Nakazawa, Minato; Sato, Naoki; Wada, Naoki; Shirakura, Kenji; Koyama, Hiroshi

doi:10.1007/s12011-011-9107-9

Cited by 7 publications

(2 citation statements)

References 32 publications

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“…Severe disease is associated with strongly altered serum trace element concentrations, notably low concentrations of Se (28)(29)(30) and Zn (29-32), and slightly or strongly elevated serum Cu (32,33). The observed changes are in line with prior reports on the acute phase response in infection or sepsis, where serum Se is established as a negative (34)(35)(36), and serum Cu as a positive acute phase reactant (37,38). Response of Zn seems more complex as it involves strong and dynamic redistribution between the tissues (39).…”

Section: Introductionsupporting

confidence: 85%

Association of COVID-19 mortality with serum selenium, zinc and copper: Six observational studies across Europe

et al. 2022

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IntroductionCertain trace elements are essential for life and affect immune system function, and their intake varies by region and population. Alterations in serum Se, Zn and Cu have been associated with COVID-19 mortality risk. We tested the hypothesis that a disease-specific decline occurs and correlates with mortality risk in different countries in Europe.MethodsSerum samples from 551 COVID-19 patients (including 87 non-survivors) who had participated in observational studies in Europe (Belgium, France, Germany, Ireland, Italy, and Poland) were analyzed for trace elements by total reflection X-ray fluorescence. A subset (n=2069) of the European EPIC study served as reference. Analyses were performed blinded to clinical data in one analytical laboratory.ResultsMedian levels of Se and Zn were lower than in EPIC, except for Zn in Italy. Non-survivors consistently had lower Se and Zn concentrations than survivors and displayed an elevated Cu/Zn ratio. Restricted cubic spline regression models revealed an inverse nonlinear association between Se or Zn and death, and a positive association between Cu/Zn ratio and death. With respect to patient age and sex, Se showed the highest predictive value for death (AUC=0.816), compared with Zn (0.782) or Cu (0.769).DiscussionThe data support the potential relevance of a decrease in serum Se and Zn for survival in COVID-19 across Europe. The observational study design cannot account for residual confounding and reverse causation, but supports the need for intervention trials in COVID-19 patients with severe Se and Zn deficiency to test the potential benefit of correcting their deficits for survival and convalescence.

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Section: Introductionsupporting

confidence: 85%

Association of COVID-19 mortality with serum selenium, zinc and copper: Six observational studies across Europe

et al. 2022

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“…Plasma selenium concentration decreases during inflammation because albumin, which is one of the carrier proteins for selenium, is a negative acute-phase protein ( 28 ). We used correlation analysis to examine the relation between plasma selenium concentration and plasma concentrations of CRP and AGP, separately, at 36 wk of gestation.…”

Section: Methodsmentioning

confidence: 99%

Provision of Small-Quantity Lipid-Based Nutrient Supplements Increases Plasma Selenium Concentration in Pregnant Women in Malawi: A Secondary Outcome of a Randomized Controlled Trial

Haskell

Maleta

Jorgensen

et al. 2022

Current Developments in Nutrition

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Background Pregnant women in Malawi are at risk of selenium deficiency, which may have adverse effects on pregnancy outcomes. Interventions for improving selenium status are needed. Objectives The effect of provision of small-quantity lipid-based nutrient supplements (SQ-LNS) to Malawian women during pregnancy on their plasma selenium concentrations was assessed at 36 wk gestation. Methods Pregnant women (≤20 wk gestation) were randomized to receive daily either: 1) iron and folic acid (IFA); 2) multiple micronutrients (MMN; 130 µg selenium/capsule) or 3) SQ-LNS (130 µg selenium/20 g). Plasma selenium concentrations were measured by ICP-MS at baseline and after at least 16 wk of intervention (at 36 wk gestation) and compared by intervention group. Results At 36 wk gestation, median (Q1, Q3) plasma selenium concentrations (µmol/L) were 0.96 (0.73, 1.23), 0.94 (0.78, 1.18), and 1.01 (0.85, 1.28) in the IFA, MMN and SQ-LNS groups respectively. Geometric mean (GM) plasma selenium concentration was 5.4% (95%CI:1.8%, 9.0%) higher in the SQ-LNS group than in the MMN group and tended to be higher than in the IFA group (+4.2% (95%CI: 1.0%, 7.8%). The prevalence of adjusted plasma selenium concentrations < 1 µmol/L was 55.1%, 57.8% and 47.3% in the IFA, MMN, and SQ-LNS groups, respectively; it was lower in the SQ-LNS group than in the MMN group, OR = 0.44 (95%CI:0.24, 0.83), and tended to be lower than in the IFA group, OR = 0.54 (95%CI:0.29, 1.03). There was a significant interaction between baseline plasma selenium concentration and intervention group (P = 0.003). In the lowest tertile of baseline selenium concentrations, GM (95%CI) plasma selenium concentration was higher, and the prevalence of low values was lower in the SQ-LNS group compared to the MMN and IFA groups at 36 wk gestation (P ≤ 0.007). Conclusion Provision of SQ-LNS containing selenium to pregnant women can be an effective strategy for improving their selenium status. Clinicaltrials.gov identifier: NCT01239693.

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Effects of Selenium Supplementation on the Diabetic Condition Depend on the Baseline Selenium Status in KKAy Mice

Febiyanto

Yamazaki

Kameo

et al. 2017

Biol Trace Elem Res

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Oxidative stress in obesity leads to insulin resistance in type 2 diabetes. Some selenoproteins possess antioxidant properties, suggesting that selenium (Se) may protect against type 2 diabetes; however, evidence from epidemiological studies is contradictory. We hypothesized that Se status before supplementation (baseline) contributes to the supplementation outcome. This study aimed to clarify the influence of baseline Se status on the effect of Se supplementation on the diabetic condition. Six-week-old KKAy mice were fed a diet without supplemental Se or with 0.1 ppm Se in the form of L-selenomethionine (SeM) for 2 weeks to create low-Se and sufficient-Se baseline statuses, respectively. For the next 4 weeks, low-Se mice were given a SeM (0.5 ppm Se)-supplemented diet, and sufficient-Se mice were given either a SeM (0.5 ppm Se)- or sodium selenite (0.5 ppm Se)-supplemented diet; control groups continued on baseline diets. Serum Se concentrations, glutathione peroxidase (GPx) activities, adiponectin levels, glucose tolerance, and insulin sensitivity were analyzed. All mice became diabetic during the 2-week baseline induction period. At the end of the supplementation period, Se-receiving groups demonstrated significantly higher Se concentrations and GPx activities than their respective controls. Sufficient-Se mice receiving SeM had lower blood glucose levels and better insulin sensitivity than control and sodium selenite-receiving mice, whereas low-Se mice receiving SeM showed no such improvements compared with their controls. Our results suggest that Se supplementation in the form of SeM may help prevent type 2 diabetes aggravation in people taking the 55 μg/day Se recommended dietary allowance.

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Acute Phase Response of Selenium Status and Glutathione Peroxidase Activity in Blood Plasma Before and After Total Knee Arthroplasty Surgery

Cited by 7 publications

References 32 publications

Association of COVID-19 mortality with serum selenium, zinc and copper: Six observational studies across Europe

Association of COVID-19 mortality with serum selenium, zinc and copper: Six observational studies across Europe

Provision of Small-Quantity Lipid-Based Nutrient Supplements Increases Plasma Selenium Concentration in Pregnant Women in Malawi: A Secondary Outcome of a Randomized Controlled Trial

Effects of Selenium Supplementation on the Diabetic Condition Depend on the Baseline Selenium Status in KKAy Mice

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