Selenium deficiency associated porcine and human cardiomyopathies

Oropeza-Moe, Marianne; Wisløff, Helene; Bernhoft, Aksel

doi:10.1016/j.jtemb.2014.09.011

Cited by 79 publications

(50 citation statements)

References 132 publications

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“…The recommended daily intake of Se varies with age, sex and reproductive condition of the female population. For example, the recommended dietary allowance for lactating women (70 µg day -1 ) is greater than that of the pregnant women (60 µg day -1 ) in the USA [113]. However, they are the same (30-70 µg day -1 ) in some parts of Europe (Germany, Austria, Switzerland) [113].…”

Section: Human Dietary Selenium Intakementioning

confidence: 99%

Selenium in Soil-Crop-Animal System: A Holistic Perspective to Manage Animal and Human Health

Saha¹

2017

IJAAS

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Selenium (Se) dependent enzymes play important roles in physiological functions such as thyroid hormone metabolism, strengthens anti-oxidant defense system and immune system. However, about 800 million people worldwide are believed to be deficient in Se which is attributed to low Se levels in the soil. This is because Se in plant and animal products in human diet depends upon the available Se in the soil. Deficiency of Se can be prevented or treated by adequate dietary intake or through direct supplementation. There have been reports that patients with dilated cardiomyopathy, HIV viral loads and cancer have responded to Se supplementation. However, food fortification has been found to be more efficient than supplementation. Both agronomic biofortification and genetic biofortification have been used to increase Se content of food crops and animal products. Genetic engineering makes use of key genes of Se hyperaccumulators to increase Se accumulating potential of food crops. Agronomic biofortification increases Se content of food crops by adding Se rich fertilizers to the soil or foliar application of Se. Selenium can also be added to animal diets or feedstuff to increase Se content of meat, eggs, and milk. Although inorganic forms of Se are approved as feed additives, they are less efficient than organic sources such as selenomethionine (SeMet) which is the dominant form in plants and animals. Animal products have been found to have higher Se content than plant products with fish having the highest Se content. Fruits and vegetables have a low content of Se probably because of their low protein content. Recommendations for dietary intake of Se vary with country, age and sex. There are concerns that the present recommended Se daily allowance may not be adequate due to discovery of other selenoenzymes with higher Se requirements than gluthathione peroxidase. There may be a need to review the current recommended daily allowance for Se in order to improve human health.

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Section: Human Dietary Selenium Intakementioning

confidence: 99%

Selenium in Soil-Crop-Animal System: A Holistic Perspective to Manage Animal and Human Health

Saha¹

2017

IJAAS

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“…Selenium deficiency results in a variety of cardiovascular diseases, including Keshan disease. Keshan disease, a cardiomyopathy endemic to China, is characterized by heart failure and severe cardiomyopathy, typically with arrhythmia and congestive heart failure (15,16). Our previous study demonstrated that reactive oxygen species accumulation and myocardial injury were features of a mouse model of selenium deficiency (17).…”

Section: Introductionmentioning

confidence: 99%

Role of tRNA selenocysteine 1 associated protein 1 in the proliferation and apoptosis of cardiomyocyte-like H9c2 cells

Cheng

Shi

et al. 2016

Molecular Medicine Reports

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Transfer RNA selenocysteine 1 associated protein 1 (Trnau1ap) serves an essential role in the synthesis of selenoproteins, which have critical functions in numerous biological processes. Selenium deficiency results in a variety of diseases, including cardiac disease. However, the mechanisms underlying myocardial injury induced by selenium deficiency remain unclear. The present study examined the effects of Trnau1ap under‑ and overexpression in cardiomyocyte‑like H9c2 cells, by transfection with small interfering RNA and an overexpression plasmid, respectively. Expression levels of glutathione peroxidase, thioredoxin reductase and selenoprotein K were decreased in Trnau1ap‑underexpressing cells, and increased in Trnau1ap‑overexpressing cells. Using MTT, proliferating cell nuclear antigen, annexin V and caspase‑3 activity assays, it was demonstrated that reducing Trnau1ap expression levels inhibited the proliferation of H9c2 cells and induced apoptosis. Conversely, increasing Trnau1ap expression levels promoted cell growth. Western blot analysis revealed that the phosphoinositide 3‑kinase/protein kinase B signaling pathway was activated in Trnau1ap‑underexpressing cells. Furthermore, the apoptotic pathway was activated in these cells, evidenced by relatively greater expression levels of B‑cell lymphoma (Bcl‑2)‑associated X protein and reduced expression levels of Bcl‑2. Taken together, these findings suggest that Trnau1ap serves a key role in the proliferation and apoptosis of H9c2 cells. The present study provides insight into the underlying mechanisms of myocardial injury induced by selenium deficiency.

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“…Se deficiency causes arrhythmias, heart failure, cardiomegaly, cardiomyopathy, thromboemboly, myocardial infarction [2][3][4]. As well, it decreases protective ability of the body to free radicals [5], including reactive oxygen species (ROS) during oxidative stress.…”

Section: Introductionmentioning

confidence: 99%