Effect of High Dose of Selenium Nanoparticles on Alimentary Tract in Rodents

Khubulava, Salome; Chichiveishvili, Nino; Shavshishvili, Naili; Mulkijanyan, Karen; Khodeli, N; Jangavadze, M.; Tsagareli, Z; Dgebuadze, M; Phichkhaia, Giorgi

doi:10.35248/2157-7439.19.10.531

Cited by 6 publications

(10 citation statements)

References 25 publications

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“…However, no significant changes were observed after a 90-day exposure to a dose of 500 mg/kg (Khubulava et al, 2019).…”

Section: Effects Of Np Of Se or Its Compounds On Laboratory Rodents S...mentioning

confidence: 79%

“…Zhang et al (2019) also reported an LD50 of over 36 Se/kg for male and female rats. Lesnichaya et al (2020) found an LD50 of over 2000 mg/kg for mice, while Khubulava et al (2019) reported an LD50 of over 5000 mg/kg for rats.…”

Section: The Median Lethal Dose For the Np Of Se And Its Compoundsmentioning

confidence: 99%

“…Some researchers have associated the observed intestinal alterations reported by Khubulava et al (2019) with the fact that this organ is involved in detoxification processes (Strubelt et al, 1996).…”

Section: Effects Of Np Of Se or Its Compounds On Laboratory Rodents S...mentioning

confidence: 99%

“…4.8 | The median lethal dose for the NP of Se and its compounds Khubulava et al (2019) did not aim to determine the LD50. The study was conducted on nanoparticles with a size under 100 nm, with each group consisting of one female rat and two male rats receiving single doses of 1000 mg/kg and 5000 mg/kg.…”

Section: Noael and Loaelmentioning

confidence: 99%

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Toxicological effects of selenium nanoparticles in laboratory animals: A review

Ryabova

Sutunkova

Minigalieva

et al. 2023

J of Applied Toxicology

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This paper provides a comprehensive summary of the main toxicological studies conducted on selenium nanoparticles (NPs) using laboratory animals, up until February 28, 2023. A literature search revealed 17 articles describing experimental studies conducted on warm‐blooded animals. Despite some uncertainties, in vivo studies have demonstrated that selenium NPs have an adverse effect on laboratory animals, as evidenced by several indicators of general toxic action. These effects include reductions of body mass, changes in hepatotoxicity indices (increased enzyme activity and accumulation of selenium in the liver), and the possibility of impairment of fatty acid, protein, lipid, and carbohydrate metabolisms. However, no specific toxic action attributable solely to selenium has been identified. The LOAEL and NOAEL values are contradictory. The NOAEL was 0.22 mg/kg body weight per day for males and 0.33 mg/kg body weight per day for females, while the LOAEL was assumed to be a dose of 0.05 mg/kg of nanoselenium. This LOAEL value is much higher for rats than for humans. The relationship between the adverse effects of selenium NPs and exposure dose is controversial and presents a wide typological diversity. Further research is needed to clarify the absorption, metabolism, and long‐term toxicity of selenium NPs, which is critical to improving the risk assessment of these compounds.

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“…However, no significant changes were observed after a 90-day exposure to a dose of 500 mg/kg (Khubulava et al, 2019).…”

Section: Effects Of Np Of Se or Its Compounds On Laboratory Rodents S...mentioning

confidence: 79%

Section: The Median Lethal Dose For the Np Of Se And Its Compoundsmentioning

confidence: 99%

Section: Effects Of Np Of Se or Its Compounds On Laboratory Rodents S...mentioning

confidence: 99%

Section: Noael and Loaelmentioning

confidence: 99%

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Toxicological effects of selenium nanoparticles in laboratory animals: A review

Ryabova

Sutunkova

Minigalieva

et al. 2023

J of Applied Toxicology

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show abstract

“…Khubulava et al [4] have evaluated the effect of single and continuous high dose of selenium nanoparticles through oral administration on the alimentary tract. The results revealed that multiple exposures at regular intervals was less toxic and did not cause gastritis, gastric metaplasia, haemorrhage or intestinal wall disorganization when compared to single exposure.…”

Section: Editor Notementioning

confidence: 99%

Nanotechnology: Nanoparticle Characterization and Application in Pharmacology and Toxicology

Ostafin¹

2019

J Nanomed Nanotechnol

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Biotransformation of selenium in the mycelium of the fungus Phycomyces blakesleeanus

et al. 2022

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Biotransformation of toxic selenium ions to non-toxic species has been mainly focused on biofortification of microorganisms and production of selenium nanoparticles (SeNPs), while far less attention is paid to the mechanisms of transformation. In this study, mycelium of fungus Phycomyces blakesleeanus was exposed to selenite (Se +4 ) to examine its ability to reduce Se +4 to nanoparticles, as well as to elucidate the mechanisms of reduction itself. Red coloration and pungent odor that appeared after only a few hours of incubation with 10 mM Se +4 indicate formation of SeNPs and volatile methylated selenium compounds. SEM-EDS confirmed pure selenium NPs with an average diameter of 57 nm, which indicates to potentially very good medical, optical and photoelectric characteristics. XANES spectroscopy of mycelium revealed concentration dependent mechanisms of reduction, where 0.5 mM Se +4 led to predominant formation of Se-S containing organic molecules, while 10 mM Se +4 induced production of biomethylated selenide (Se -2 ) in the form of volatile dimethylselenide (DMSe) and selenium nanoparticles (SeNPs), with SeNPs/DMSe ratio rising with incubation time. Several structural forms of elemental selenium were detected, predominantly monoclinic Se 8 chains, together with trigonal Se polymer chain, Se 8 and Se 6 ring structures.

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Effect of High Dose of Selenium Nanoparticles on Alimentary Tract in Rodents

Abstract: Nanomedicine & Nanotechnology J o ur nal of N a n o m ed icine & N a n o te chnolo g y

Cited by 6 publications

References 25 publications

Toxicological effects of selenium nanoparticles in laboratory animals: A review

Toxicological effects of selenium nanoparticles in laboratory animals: A review

Nanotechnology: Nanoparticle Characterization and Application in Pharmacology and Toxicology

Biotransformation of selenium in the mycelium of the fungus Phycomyces blakesleeanus

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