Selenium Copper Interaction in Goats

Hussein, Kamal S. M.; Jones, Bernt; Frank, Adrian

doi:10.1111/j.1439-0442.1985.tb01949.x

Cited by 12 publications

(2 citation statements)

References 20 publications

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“…Schrauzer (2009) reported that the sequestration of toxic elements by Se represents an efficient detoxification mechanism, but also results in the physiological inactivation and loss of Se. In our study, as ruminants have also demonstrated that after injection of Se, Cu concentration in the liver increased in animals receiving both normal (Hussein et al 1985) or Cu deficient diets (Thomson and Lawson 1970). However, Kotyzova et al (2009) reported that in long term Se deficiency of rats an increase of liver Cu concentration was noted.…”

Section: Discussionsupporting

confidence: 62%

Influence of organic selenium supplementation on the accumulation of toxic and essential trace elements involved in the antioxidant system of chicken

Pappas

Zoidis

Georgiou

et al. 2011

Food Additives & Contaminants: Part A

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Section: Discussionsupporting

confidence: 62%

Influence of organic selenium supplementation on the accumulation of toxic and essential trace elements involved in the antioxidant system of chicken

Pappas

Zoidis

Georgiou

et al. 2011

Food Additives & Contaminants: Part A

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“…In a previous study (12) we found that intramuscular Se injections potentiated the toxic effects of Cu in goats given oral doses of Cu, resulting in a rapid onset of haemolytic crisis (HC) due to chronic copper poisoning (CCP). This was not expected since Se has earlier been shown to provide protection against the toxic effects of heavy metals, e. g. cadmium, mercury and thallium (19).…”

Section: Introductionmentioning

confidence: 99%

Influence of Intramuscular Selenium Injections on Copper Metabolism in Copper‐loaded Sheep

Hussein

Frank

Jones

1985

Zentralblatt für Veterinärmedizin Reihe A

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Summary Fifteen apparently normal adult Swedish landrace sheep were divided into three groups: a copper group (Cu group) and a copper plus selenium group (Cu + Se group), each consisting of six animals, and a copper control group (Cu control group) with three animals. The sheep of the Cu + Se group were given intramuscular injections of an Se vitamin E preparation (0.6 mg Se and 30 mg vit. E per 10 kg BW) for three months. All sheep in the three groups were then given copper sulphate orally (15 mg Cu/kg BW) five days per week. Sheep injected with Se had significantly higher blood GSH‐Px activity at the start of Cu dosing. These animals developed clinical signs of CCP earlier than sheep in the two other groups. Possible reasons for this increased sensitivity are discussed. The sheep of the Cu + Se and Cu control groups showed decreased levels of Hb concentration and PCV at the time of the haemolytic crisis. At this time they also showed increased activities of serum ASAT, γ‐GT and S‐CK. Macroscopic and microscopic changes seen in livers and kidneys of the sheep with HC were typical of CCP. Zusammenfassung Einfluß von intramuskulären Seleninjektionen auf den Kupferstoffwechsel von Kupfer‐supplementierten Schafen Fünfzehn klinisch gesunde erwachsene Schafe der Schwedischen Landrasse wurden in drei Gruppen eingeteilt: Eine Kupfergruppe (Cu) und eine Kupfer + Selengruppe (Cu + Se) mit je 6 Tieren sowie eine Kupfer‐Kontrollgruppe (Cu‐Kontrolle) mit 3 Tieren. Den Schafen der Cu + Se‐Gruppe wurde monatlich ein Selen‐Vitamin‐E‐Präparat intramuskulär injiziert (0,6 mg Se + 30 mg Vitamin E/10 kg KGW), beginnend 3 Monate vor der Kupferverabreichung. Sämtliche Schafe in allen drei Gruppen erhielten während 5 Tagen pro Woche je 15 mg Kupfer/kg KGW als Sulfat oral verabreicht. Schafe, denen Selen verabreicht wurde, wiesen zu Beginn der Kupferverabreichung eine signifikant höhere GSH‐Px‐Aktivität auf. Bei diesen Tieren manifestierten sich die Anzeichen einer chronischen Kupfervergiftung (CCP) früher als bei den Schafen der anderen Gruppen. Die möglichen Ursachen der größeren Sensitivität werden diskutiert. Die Schafe der Cu + Se‐und der Cu‐Kontrollgruppe wiesen zum Zeitpunkt der hämolytischen Krise erniedrigte Hb‐Konzentrationen und PCV‐Werte auf. Gleichzeitig waren die Aktivitäten der ASAT, γ‐GT und CK im Serum erhöht. Die makroskopischen und mikroskopischen Veränderungen in Leber und Nieren dieser Schafe waren typisch für eine CCP. Résumé Influence d'injections intrasmusculaires de sélénium sur le métabolisme du cuivre chez des moutons recevant une supplémentation en cuivre Quinze moutons adultes cliniquement sains de race suédoise ont été répartis en trois groupes: un groupe cuivre (Cu) et un groupe cuivre + sélénium (Cu + Se) de chacun 6 animaux, ainsi qu'un groupe de contrôle cuivre (Cu‐contrôles) avec 3 animaux. Les moutons du groupe Cu + Se ont reçu une injection intramusculaire par mois d'une préparation de vitamine E‐sélénium (0,6 mg Se + 30 mg vitamine E/10kg de poids) en ayant commencé 3 mois avant l'application de cu...

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Blood, Lymph, and Immune Systems

Smith

Sherman

2009

Goat Medicine

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Selenium Copper Interaction in Goats

Cited by 12 publications

References 20 publications

Influence of organic selenium supplementation on the accumulation of toxic and essential trace elements involved in the antioxidant system of chicken

Influence of organic selenium supplementation on the accumulation of toxic and essential trace elements involved in the antioxidant system of chicken

Influence of Intramuscular Selenium Injections on Copper Metabolism in Copper‐loaded Sheep

Blood, Lymph, and Immune Systems

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