Selenium-containing soybean antioxidant peptides: Preparation and comprehensive comparison of different selenium supplements

Zhang, Xing; He, Hui; Xiang, Jingjing; Бин, Ли; Zhao, Mengge; Hou, Tao

doi:10.1016/j.foodchem.2021.129888

Cited by 44 publications

(45 citation statements)

References 39 publications

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“…Zhang et al found that selenium-containing soybean antioxidant peptides inhibited D-galactose-induced liver injury and oxidative brain damage via the MAPK/NF-κB pathway, and played a key role in reducing organic oxidative damage during inflammation and aging. They compared the antioxidant activity of inorganic selenium, organic selenium, and selenium-free peptides and found that the effect of the selenium-enriched peptide treatment group was more significant ( 23 ). Consistent with these findings, this study revealed that PPs exhibited an ameliorative effect on the oxidative damage caused by heat stress and exercise fatigue.…”

Section: Discussionmentioning

confidence: 99%

A Comprehensive Comparison of Different Selenium Supplements: Mitigation of Heat Stress and Exercise Fatigue-Induced Liver Injury

Chen

Zhang

et al. 2022

Front. Nutr.

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This study aimed to compare the protective effects of different selenium supplements against heat stress and exercise fatigue-induced liver injury and to investigate the potential mechanisms of action. Selenium-enriched soybean protein (SePro), selenium-enriched soybean peptides (SePPs), and selenomethionine (SeMet) are organic selenium supplements in which selenium replaces the sulfur in their sulfur-containing amino acids. Common peptides (PPs) are obtained by enzymatic hydrolysis of soybean protein which was extracted from common soybean. The SePPs with higher hydrolysis degree and selenium retention were isolated via alkaline solubilization and acid precipitation and the enzymatic hydrolysis of alkaline protease, neutral protease, and papain. The results showed that SePPs could significantly increase the antioxidant levels in rats, inhibit lipid peroxidation, and reduce liver enzyme levels in rat serum, while the histological findings indicated that the inflammatory cell infiltration in the liver tissue was reduced, and new cells appeared after treatment with SePPs. Moreover, SePPs could increase glutathione (GSH) and GSH peroxidase (GSH-Px) in the liver, as well as protect the liver by regulating the NF-κB/IκB pathway, prevent interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α) release in the liver. The SePPs displayed higher antioxidant and anti-inflammatory activity in vivo than SePro, SeMet, Sodium selenite (Na2SeO3), and PPs. Therefore, SePPs could be used as a priority selenium resource to develop heatstroke prevention products or nutritional supplements.

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Section: Discussionmentioning

confidence: 99%

A Comprehensive Comparison of Different Selenium Supplements: Mitigation of Heat Stress and Exercise Fatigue-Induced Liver Injury

Chen

Zhang

et al. 2022

Front. Nutr.

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“…Recent studies have confirmed that Se-SPep is readily absorbed and displays unique biological activities, such as antioxidant, anti-inflammatory, and immune regulatory properties. 26,27,44,45 Se, which is incorporated into proteins and located in the active centers of some proteins, serves an important biological function in human health. 46 Experimental studies have demonstrated that Se protects the lungs from acute injury by activating GSH-Px, attenuating oxidants, and reducing the inflammatory response and lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

Selenium-enriched soybean peptides pretreatment attenuates lung injury in mice induced by fine particulate matters (PM2.5) through inhibition of TLR4/NF-κB/IκBα signaling pathway and inflammasome generation

Zhang

Chen

et al. 2022

Food Funct.

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“…These results suggest that soybean-derived bioactive peptides exhibit significant antioxidant activities, particularly short peptides [102]. Selenium (Se)-containing peptides [SFQ(K)SeM and SeCPEE] from soybean rich in Se also exhibited antioxidant properties by upregulating liver SOD and GSH peroxidase-1 and downregulating aspartate aminotransferase, alanine aminotransferase, and NF-κB levels through the regulation of MAPK and NF-κB signaling pathways in the presence of Se-containing peptides, which enhanced the protective effects against diseases associated with oxidative stress (Table 1) [103]. These studies show that most antioxidative properties are associated with known/unknown SPH or SPH products.…”

Section: Antioxidative Propertiesmentioning

confidence: 99%

Beneficial Effects of Soybean-Derived Bioactive Peptides

Kim

Yang²,

Kim

2021

IJMS

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Peptides present in foods are involved in nutritional functions by supplying amino acids; sensory functions related to taste or solubility, emulsification, etc.; and bioregulatory functions in various physiological activities. In particular, peptides have a wide range of physiological functions, including as anticancer agents and in lowering blood pressure and serum cholesterol levels, enhancing immunity, and promoting calcium absorption. Soy protein can be partially hydrolyzed enzymatically to physiologically active soy (or soybean) peptides (SPs), which not only exert physiological functions but also help amino acid absorption in the body and reduce bitterness by hydrolyzing hydrophobic amino acids from the C- or N-terminus of soy proteins. They also possess significant gel-forming, emulsifying, and foaming abilities. SPs are expected to be able to prevent and treat atherosclerosis by inhibiting the reabsorption of bile acids in the digestive system, thereby reducing blood cholesterol, low-density lipoprotein, and fat levels. In addition, soy contains blood pressure-lowering peptides that inhibit angiotensin-I converting enzyme activity and antithrombotic peptides that inhibit platelet aggregation, as well as anticancer, antioxidative, antimicrobial, immunoregulatory, opiate-like, hypocholesterolemic, and antihypertensive activities. In animal models, neuroprotective and cognitive capacity as well as cardiovascular activity have been reported. SPs also inhibit chronic kidney disease and tumor cell growth by regulating the expression of genes associated with apoptosis, inflammation, cell cycle arrest, invasion, and metastasis. Recently, various functions of soybeans, including their physiologically active functions, have been applied to health-oriented foods, functional foods, pharmaceuticals, and cosmetics. This review introduces some current results on the role of bioactive peptides found in soybeans related to health functions.

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Selenium-containing soybean antioxidant peptides: Preparation and comprehensive comparison of different selenium supplements

Cited by 44 publications

References 39 publications

A Comprehensive Comparison of Different Selenium Supplements: Mitigation of Heat Stress and Exercise Fatigue-Induced Liver Injury

A Comprehensive Comparison of Different Selenium Supplements: Mitigation of Heat Stress and Exercise Fatigue-Induced Liver Injury

Selenium-enriched soybean peptides pretreatment attenuates lung injury in mice induced by fine particulate matters (PM2.5) through inhibition of TLR4/NF-κB/IκBα signaling pathway and inflammasome generation

Beneficial Effects of Soybean-Derived Bioactive Peptides

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