Selenium, as selenite, prevents adipogenesis by modulating selenoproteins gene expression and oxidative stress–related genes

El-Magd, Nada F. Abo; Barbosa, Priscila Oliveira; Nick, J; Covalero, Viviana; Grignetti, Giacomo; Bermano, Giovanna

doi:10.1016/j.nut.2021.111424

Cited by 18 publications

(7 citation statements)

References 43 publications

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“…It is speculated that overexpression of GPX2 can significantly alleviate oxidative stress in 3T3-L1 adipocytes. These results are in agreement with previous publications that reported selenium directly increased GPX1 expression in adipocytes and decreased adipocyte differentiation and lipid deposition at the same time [ 23 ]. The GPX2 and GPX1 genes have similar gene functions, but the expression levels of the two genes are different [ 7 ].…”

Section: Discussionsupporting

confidence: 94%

GPX2 Gene Affects Feed Efficiency of Pigs by Inhibiting Fat Deposition and Promoting Muscle Development

Luo

Wen

et al. 2022

Animals

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GPX2 has been recognized as a potential candidate gene for feed efficiency in pigs. This article aimed to elucidate polymorphism of GPX2 associated with feed efficiency and its related molecular mechanism. In this study, seven single nucleotide polymorphisms (SNP) of GPX2 were found among 383 Duroc pigs. In addition, seven SNPs and ALGA0043483 (PorcineSNP60 BeadChip data in 600 Duroc pigs), which are near the GPX2 gene, were identified in one haplotypes block. Furthermore, associated studies showed that the genotype of GPX2 has significant association with weaning weight and 100 kg BF in Duroc pigs. In addition, the AG had no effect when the backfat became thinner, and the FCR and RFI traits had a tendency to decrease in the G3 + TT combination genotype, accompanied by an increase of GPX2 expression in backfat and muscle tissues. At the cellular level, the adipocyte proliferation and ability of adipogenic differentiation were reduced, and the lipid degradation increased in 3T3-L1 when there was overexpression of GPX2. In contrast, overexpression of the GPX2 gene can promote the muscle cell proliferation and myogenic differentiation in C2C12 cells. In other words, GPX2 has the effect of reducing fat deposition and promoting muscle development, and it is a candidate gene for backfat and feed efficiency.

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Section: Discussionsupporting

confidence: 94%

GPX2 Gene Affects Feed Efficiency of Pigs by Inhibiting Fat Deposition and Promoting Muscle Development

Luo

Wen

et al. 2022

Animals

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“…Nada et al . found that Se can inhibit fat formation by regulating selenoprotein gene expression and oxidative stress-related genes (61) . In addition, a study by Hossain et al .…”

Section: Discussionmentioning

confidence: 99%

“…Adequate intake of Se has been found to maintain tissue Se concentrations and selenoprotein activity, which is important in preventing the development of obesity and its associated metabolic disorders (59,60) . Nada et al found that Se can inhibit fat formation by regulating selenoprotein gene expression and oxidative stress-related genes (61) . In addition, a study by Hossain et al observed that Se regulated lipid metabolism in humans and rodents and increasing dietary Se intake has an important role in the prevention of obesity and diabetes (62) .…”

Section: Discussionmentioning

confidence: 99%

Association between plasma and dietary trace elements and obesity in a rural Chinese population

Liu

Huang

et al. 2023

Br J Nutr

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Trace elements may play an important role in obesity. This study aimed to assess the plasma and dietary intake levels of four trace elements, manganese, copper, zinc and selenium in a rural Chinese population and analyse the relationship between trace elements and obesity. A cross-sectional study involving 2587 participants was conducted. Logistic regression models were used to analyse the association between trace elements and obesity; Restricted cubic spline(RCS) models were used to assess the dose-response relationship between trace elements and obesity; The Weighted Quantile Sum(WQS) model was used to examine the potential interaction of four plasma trace elements on obesity. Logistic regression analysis showed that plasma selenium concentrations in the fourth quartile(Q4) exhibited a lower risk of developing obesity than the first quartile(Q1)(central obesity: OR=0.634, P=0.002; general obesity: OR=0.525, P=0.005). Plasma zinc concentration in the third quartile(Q3) showed a lower risk of developing obesity in general obesity compared to the first quartile(Q1)(OR=0.625, P=0.036). In general obesity, the risk of morbidity was 1.727 and 1.923 times higher for the second and third(Q2, Q3) quartiles of dietary manganese intake than for Q1, respectively. RCS indicated an inverse U-shaped correlation between plasma selenium and obesity. WQS revealed the combined effects of four trace elements were negatively associated with central obesity. Plasma zinc and selenium were negatively associated with obesity and dietary manganese was positively associated with obesity. The combined action of the four plasma trace elements had a negative effect on obesity.

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“…Child and adolescents' obesity has emerged as an important threat to public health; The modulation of inflammation and oxidative stress was hypothesized, while the micro-nutrient Se has been reported to possess qualities that are anti-inflammatory and anti-oxidative in nature [8].…”

Section: Discussionmentioning

confidence: 99%

Selenoprotein-p as Biomarker of Selenium Status in Obese Children and Adolescents

Mahmoud,

Elshafiey,

Elsharaby

et al. 2023

AJPR

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Background: The child and adolescent obesity have become a major public health problem. Selenoprotien p1 (SEPP1) is widely acknowledged to be among the most delicate functional indicators of Se status and it plays a role in the metabolism of Se and in anti-oxidative defense. So, we aimed to assess Selenoprotein-p level in obese children and adolescents. Methods: This cross-sectional comparative work included 60 children: 30 obese children and the control group consisted of 30 children who were healthy and matched in terms of gender and age. A comprehensive taking of history and clinical assessment with anthropometric measurements were conducted on all children and adolescents. Basic investigations and serum selenoprotien-p1 level were performed. Results: Serum selenoprotien-p1 (SEPP1) levels were substantially decreased in obese children contrasted to controls. Conclusions: Selenoprotien p1 levels were substantially decreased in obese children and adolescent. Selenoprotien p1 could be a sensitive functional biomarker of selenium status.

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Selenium, as selenite, prevents adipogenesis by modulating selenoproteins gene expression and oxidative stress–related genes

Cited by 18 publications

References 43 publications

GPX2 Gene Affects Feed Efficiency of Pigs by Inhibiting Fat Deposition and Promoting Muscle Development

GPX2 Gene Affects Feed Efficiency of Pigs by Inhibiting Fat Deposition and Promoting Muscle Development

Association between plasma and dietary trace elements and obesity in a rural Chinese population

Selenoprotein-p as Biomarker of Selenium Status in Obese Children and Adolescents

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