Selenium, Apoptosis, and Colorectal Adenomas

Connelly-Frost, Alexandra; Poole, Charles; Satia, Jessie A.; Kupper, Lawrence L.; Millikan, Robert C.; Sandler, Robert S.

doi:10.1158/1055-9965.epi-05-0759

Cited by 27 publications

(14 citation statements)

References 53 publications

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“…Se supplement can prevent tumorigenesis and decrease the incidence rate of cancer (Beno et al, 2000; Yang, 2000). High Se was associated with a reduced prevalence of colorectal adenomas (Clark et al, 1996; Connelly-Frost et al, 2006). In previous study, cells are endowed with cytoprotective mechanisms (antioxidation, scavenging free radicals, damage repair) that act to counteract the effects of free radical production (Britton, 1996).…”

Section: Discussionmentioning

confidence: 99%

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Effects of Selenium on Colon Carcinogenesis Induced by Azoxymethane and Dextran Sodium Sulfate in Mouse Model with High-Iron Diet

et al. 2011

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Selenium (Se) is known to prevent several cancers while the relationship between high iron and the risk of colorectal cancer is controversial. To investigate the effects of Se in colon carcinogenesis, we subjected three different levels of Se and high-iron diet to a mouse model of colon cancer in which animals were treated with three azoxymethane (AOM) injections followed by dextran sodium sulfate (DSS) administration. There were five experimental groups including vehicle group [normal-Fe (NFe, 45 ppm)+medium-Se (MSe, 0.1 ppm)], positive control group (AOM/DSS+NFe+MSe), AOM/DSS+high-Fe (HFe, 450 ppm)+low-Se (LSe, 0.02 ppm), AOM/DSS+HFe+MSe, and AOM/DSS+HFe+high-Se (HSe, 0.5 ppm). The animals were fed on the three different Se diets for 24 weeks. The incidence of colon tumor in the high-Se diet group (AOM/DSS+HFe+HSe) showed 19.4% lower than positive control group, 5.9% lower than AOM/DSS+HFe+MSe diet group, and 11.1% lower than AOM/DSS+HFe+LSe group. The tumor multiplicity was significantly higher in the low-Se diet group (AOM/DSS+HFe+LSe) compare to all other AOM/DSS treated groups. In the high-Se diet group, the activity of hepatic GPx was comparable to that of positive control group, and significantly higher than those of low-Se or medium-Se diet groups. Expression level of hepatic GPx-1 showed similar results. Hepatic malondialdehyde (MDA) level (indicator of oxidative stress) in the low-Se diet group showed the highest compared to the other groups, and it was significantly higher than positive control group. In the high-Se diet group the level of MDA in the liver was significantly lower than all other AOM/DSS treated groups. High-Se diet group showed significantly lower proliferative index than low-Se and medium-Se groups. The apoptotic indices in low-Se group and medium-Se group were significantly lower than positive control group. However, apoptotic index of high-Se diet group was significantly higher than all other AOM/DSS treated groups. These findings suggest that dietary Se supplement may have protective effect against colon cancer by decreasing proliferation, increasing apoptosis of tumor cells, and reducing oxidative stress in mice with high iron diet.

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Section: Discussionmentioning

confidence: 99%

“…It is likely that Se acts as an anti-carcinogen through several mechanisms, which vary in importance based on disease status of the individual (Connelly-Frost et al, 2006). Free radicals are natural by-products of oxygen metabolism that may contribute to the development of chronic diseases such as cancer and heart disease (Combs et al, 2001).…”

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confidence: 99%

Effects of Selenium on Colon Carcinogenesis Induced by Azoxymethane and Dextran Sodium Sulfate in Mouse Model with High-Iron Diet

et al. 2011

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“…Some of them observed a significantly lower level of Se in serum of CRC patients than in healthy subjects, or a significantly higher risk to develop CRC and lower cumulated cancerrelated survival rates for subject presenting low serum Se levels [3][4][5]. A similar behaviour was noticed in patients affected by colorectal adenoma, the precursor lesion in most CRC cases [6][7][8][9]. Selenium levels have also been associated with the CRC stage (from adenomatous polyps to local and metastatic cancer, respectively) [10].…”

Section: Introductionmentioning

confidence: 90%

Serum seleno-proteins status for colorectal cancer screening explored by data mining techniques - a multidisciplinary pilot study

Roman

Jitaru

Agostini

et al. 2012

Microchemical Journal

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“…Fish also contains vitamin D, which has been inversely associated with colorectal cancer risk (8). Selenium, another nutrient contained in fish, has been shown to exert anticancer effects in in vitro, animal and human studies (9,10).…”

Section: Introductionmentioning

confidence: 99%

Fish Consumption and Colorectal Cancer Risk: An Evaluation Based on a Systematic Review of Epidemiologic Evidence Among the Japanese Population

Pham

Mizoue

Tanaka

et al. 2013

Japanese Journal of Clinical Oncology

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Objective: The association between fish consumption and colorectal cancer risk remains inconclusive. The present study systematically reviewed and meta-analyzed epidemiologic data on the association between fish consumption and colorectal cancer risk among Japanese. Methods: Original data were obtained from MEDLINE searched using PubMed or from searches of the Ichushi database, complemented with manual searches. The associations were evaluated based on the strength of evidence, the magnitude of association and biologic plausibility. Meta-analysis was conducted according to the study design. Results: Five cohort studies and 12 case -control studies were identified. Fish consumption was not significantly associated with colorectal, colon or rectal cancer risks. One cohort study showed a weak positive association with colorectal cancer, and another showed a weak inverse association with colon cancer in men and a moderate and weak inverse association with colon and rectal cancers in women. As regards case -control studies, four studies reported a weak inverse association, whereas one showed a weak positive association with colon cancer. Regarding rectal cancer, four case-control studies showed a weak inverse association, but two reported a weak-to-moderate positive association. The pooled relative risk/odds ratio (95% confidence interval) of colorectal cancer for the highest versus lowest category of fish consumption was 1.03 (0.89 -1.18) and 0.84 (0.75 -0.94) for cohort and case -control studies, respectively. Conclusions: There was insufficient evidence to support an association between fish consumption and the risk of colorectal cancer among Japanese.

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Selenium, Apoptosis, and Colorectal Adenomas

Cited by 27 publications

References 53 publications

Effects of Selenium on Colon Carcinogenesis Induced by Azoxymethane and Dextran Sodium Sulfate in Mouse Model with High-Iron Diet

Effects of Selenium on Colon Carcinogenesis Induced by Azoxymethane and Dextran Sodium Sulfate in Mouse Model with High-Iron Diet

Serum seleno-proteins status for colorectal cancer screening explored by data mining techniques - a multidisciplinary pilot study

Fish Consumption and Colorectal Cancer Risk: An Evaluation Based on a Systematic Review of Epidemiologic Evidence Among the Japanese Population

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