Selenium and zinc protections against metal-(loids)-induced toxicity and disease manifestations: A review

Rahman, Md. Mostafizur; Hossain, Kaniz Fatima Binte; Banik, Subrata; Sikder, Md. Tajuddin; Akter, Mahmuda; Bondad, Serene Ezra Corpus; Rahaman, Md. Shiblur; Hosokawa, Toshiyuki; Saito, Takeshi

doi:10.1016/j.ecoenv.2018.10.054

Cited by 126 publications

(37 citation statements)

References 213 publications

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“…Se is considered to exert an overall protection against toxicity induced by heavy metals such as Cd, Pb, As and Hg [55], mainly through the sequestration of these elements into biologically inert complexes and/or through the action of Se-dependent antioxidant enzymes [55]. This protection from Cd toxicity occurs regardless of the Se form (as selenite, selenomethionine, nanoSe, or Se from lentils) [56].…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Myo-Inositol and Selenium on Cadmium-Induced Thyroid Toxicity in Mice

et al. 2020

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Cadmium (Cd) damages the thyroid gland. We evaluated the effects of myo-inositol (MI), seleno-L-methionine (Se) or their combination on the thyroids of mice simultaneously administered with Cd chloride (CdCl2). Eighty-four male mice were divided into 12 groups (seven mice each). Six groups (controls) were treated with 0.9% NaCl (vehicle), Se (0.2 mg/kg/day), Se (0.4 mg/kg/day), MI (360 mg/kg/day), MI+Se (0.2 mg/kg) and MI+Se (0.4 mg/kg). The other six groups were treated with CdCl2 (2 mg/kg), CdCl2+MI, CdCl2+Se (0.2 mg/kg), CdCl2+Se (0.4 mg/kg), CdCl2+MI+Se (0.2 mg/kg) and CdCl2+MI+Se (0.4 mg/kg). An additional group of CdCl2-challenged animals (n = 7) was treated with resveratrol (20 mg/kg), an effective and potent antioxidant. All treatments lasted 14 days. After sacrifice, the thyroids were evaluated histologically and immunohistochemically. CdCl2 reduced the follicular area, increased the epithelial height, stroma, and cells expressing monocyte chemoattractant protein-1 (MCP-1) and C-X-C motif chemokine 10 (CXCL10). CdCl2+Se at 0.2/0.4 mg/kg insignificantly reversed the follicular and stromal structure, and significantly decreased the number of MCP-1 and CXCL10-positive cells. CdCl2+MI significantly reversed the thyroid structure and further decreased the number of MCP-1 and CXCL10-positive cells. CdCl2+MI+Se, at both doses, brought all indices to those of CdCl2-untreated mice. MI, particularly in association with Se, defends mice from Cd-induced damage. The efficacy of this combination was greater than that of resveratrol, at least when using the follicular structure as a read-out for a comparison. We suggest that the use of these nutraceuticals, more specifically the combination of MI plus SE, can protect the thyroid of Cd-exposed subjects.

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Section: Discussionmentioning

confidence: 99%

Protective Effects of Myo-Inositol and Selenium on Cadmium-Induced Thyroid Toxicity in Mice

et al. 2020

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“…As-containing compounds cause an abnormal pregnancy outcome in experimental animals at sufficiently high levels. Abnormal pregnancy outcomes, including miscarriages, stillbirths, and infant deaths have been reported in communities that consumed drinking water with As concentrations above 50 ppb (µg/l) and often above this level (Amadi et al 2017;Concha et al 1998;Rahman et al 2019). Epidemiological studies of areas with high levels of As in drinking water indicate an association between in utero As exposure and the development of adult diseases such as cancer, chronic pulmonary disease, cardiovascular disease, and diabetes (Sanchez et al 2016;Steinmaus et al 2014;Vahter 2008;Young et al 2018).…”

Section: Clinical Features Of Arsenic Toxicitymentioning

confidence: 99%

“…The relieving action of Se against As toxicity, both in vitro and in vivo has also been investigated. Defense from oxidative injury due to As treatment has been demonstrated as a detoxification pathway by Se supplementation through the selenoproteins upregulation (GPx and thioredoxin reductase) (Rahman et al 2019). The combination of As and Se enhanced antioxidant defense in As-treated PC12 cells, positively regulating autophagy and apoptosis .…”

Section: Natural Products As Promising Chelating and Detoxifying Agenmentioning

confidence: 99%

Arsenic intoxication: general aspects and chelating agents

et al. 2020

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Arsenic (As) is widely used in the modern industry, especially in the production of pesticides, herbicides, wood preservatives, and semiconductors. The sources of As such as contaminated water, air, soil, but also food, can cause serious human diseases. The complex mechanism of As toxicity in the human body is associated with the generation of free radicals and the induction of oxidative damage in the cell. One effective strategy in reducing the toxic effects of As is the usage of chelating agents, which provide the formation of inert chelator-metal complexes with their further excretion from the body. This review discusses different aspects of the use of metal chelators, alone or in combination, in the treatment of As poisoning. Consideration is given to the therapeutic effect of thiol chelators such as meso-2,3-dimercaptosuccinic acid, sodium 2,3-dimercapto-1-propanesulfonate, 2,3-dimercaptopropanol, penicillamine, ethylenediaminetetraacetic acid, and other recent agents against As toxicity. The review also considers the possible role of flavonoids, trace elements, and herbal drugs as promising natural chelating and detoxifying agents.

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“…Many micronutrients play important roles in regulating the homeostasis of general processes closely related to systemic metabolism, including redox and inflammatory pathways [ 2 ]. Micronutrients act as cofactors that participate in one-carbon metabolism and important cellular pathways (vitamin B9 (VB9)) [ 3 ] and interact with enzymes such as superoxide dismutase and glutathione peroxidase (GPX), which are involved in defence mechanisms (Se, zinc (Zn), copper (Cu)) [ 4 , 5 , 6 ]. Micronutrients also have roles as chemical antioxidants (vitamins C and E (VC and VE)) [ 7 ] and are involved in protein synthesis (vitamin B6 (VB6)).…”

Section: Introductionmentioning

confidence: 99%

“…Like Se, Zn is related to the immune function of the body [ 13 , 14 ], antagonizing the toxicity of heavy metals [ 5 ]. As a component of enzymes [ 15 ], Zn participates in the process of cell growth, division and differentiation [ 16 ] and affects the synthesis of nucleic acids and proteins [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Supplements on the Bioaccessibility of Se, Zn and Cd in Rice: Preliminary Observations from In Vitro Gastrointestinal Simulation Tests

Zhang

et al. 2020

IJERPH

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Trace elements such as selenium (Se) and zinc (Zn) are essential elements in the human body, while cadmium (Cd) has no physiological function. A high proportion of people consume dietary supplements to enhance the performance of the body or alter the nutrient contents within the body. Therefore, this study was conducted to evaluate the interaction effects of several popular dietary supplements on the bioaccessibility of Se, Zn and Cd in rice with the hope of identifying dietary supplements that can increase rice Se and Zn bioaccessibility but decrease rice Cd bioaccessibility. The results from in vitro gastrointestinal simulation tests showed that the bioaccessibility of these elements in rice was in the order of Cd (52.07%) > Zn (36.63%) > Se (10.19%) during the gastric phase and Zn (26.82%) > Cd (18.72%) > Se (14.70%) during the intestinal phase. The bioaccessibility of Se during the intestinal phase was greater than that during the gastric phase, and the bioaccessibility of Zn and Cd were the opposite. The bioaccessibility of Se significantly increased in response to vitamin C (VC), vitamin E (VE), vitamin B6 (VB6) and vitamin B9 (VB9), especially VC, which also increased the bioaccessibility of Zn and decreased that of Cd. Procyanidins (OPC), methionine (Met) and coenzyme Q10 (Q10) significantly reduced the bioaccessibility of Se. These results suggest that the reasonable use of dietary supplements can effectively regulate the in vivo contents of trace elements, which provide valuable information for developing health interventions to address problems for specific people, especially selenium-deficient people.

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Selenium and zinc protections against metal-(loids)-induced toxicity and disease manifestations: A review

Cited by 126 publications

References 213 publications

Protective Effects of Myo-Inositol and Selenium on Cadmium-Induced Thyroid Toxicity in Mice

Protective Effects of Myo-Inositol and Selenium on Cadmium-Induced Thyroid Toxicity in Mice

Arsenic intoxication: general aspects and chelating agents

Effects of Dietary Supplements on the Bioaccessibility of Se, Zn and Cd in Rice: Preliminary Observations from In Vitro Gastrointestinal Simulation Tests

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