Selenium and prostate cancer: systematic review and meta-analysis

Hurst, Rachel; Hooper, Lee; Norat, Teresa; Lau, Raymond; Aune, Dagfinn; Greenwood, Darren C.; Vieira, R.; Collings, Rachel; Harvey, Linda J.; Sterne, Jonathan A C; Beynon, Rebecca; Savović, Jelena; Fairweather‐Tait, Susan J.

doi:10.3945/ajcn.111.033373

Cited by 131 publications

(102 citation statements)

References 87 publications

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“…265 A similar relation was observed in a metaanalysis on prostate cancer, where plasma/serum Se negatively correlated with prostate cancer risk only below 170 ng mL À1 . 253 These findings suggest that Se exhibits a U-shape relation with cancer risk, in analogy with many other antioxidants. 3 Still, all observational studies and randomized trials appear to be highly conditioned by the composition of the population with respect to covariates and confounding factors including baseline levels of Se intake, co-supplemented antioxidants, age, gender, diet, lifestyle, time scale and others.…”

Section: Male Infertilitymentioning

confidence: 88%

Selenium biochemistry and its role for human health

Roman¹,

Jitaru²,

Barbante³

2014

Metallomics

629

451

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Despite its very low level in humans, selenium plays an important and unique role among the (semi)metal trace essential elements because it is the only one for which incorporation into proteins is genetically encoded, as the constitutive part of the 21st amino acid, selenocysteine. Twenty-five selenoproteins have been identified so far in the human proteome. The biological functions of some of them are still unknown, whereas for others there is evidence for a role in antioxidant defence, redox state regulation and a wide variety of specific metabolic pathways. In relation to these functions, the selenoproteins emerged in recent years as possible biomarkers of several diseases such as diabetes and several forms of cancer. Comprehension of the selenium biochemical pathways under normal physiological conditions is therefore an important requisite to elucidate its preventing/therapeutic effect for human diseases. This review summarizes the most recent findings on the biochemistry of active selenium species in humans, and addresses the latest evidence on the link between selenium intake, selenoproteins functionality and beneficial health effects. Primary emphasis is given to the interpretation of biochemical mechanisms rather than epidemiological/observational data. In this context, the review includes the following sections: (1) brief introduction; (2) general nutritional aspects of selenium; (3) global view of selenium metabolic routes; (4) detailed characterization of all human selenoproteins; (5) detailed discussion of the relation between selenoproteins and a variety of human diseases.

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Section: Male Infertilitymentioning

confidence: 88%

Selenium biochemistry and its role for human health

Roman¹,

Jitaru²,

Barbante³

2014

Metallomics

629

451

View full text Add to dashboard Cite

show abstract

“…In our study, Selenium level was found to be significantly lower (p = 0.01) in PCa versus BPH. Although, observational epidemiological studies suggest an inverse association between selenium and risk of prostate cancer [19,20], randomized controlled trials of selenium supplementation have reported conflicting results [21,22]. In the Selenium and Vitamin E Cancer Prevention Trial (SELECT) clinical trial, selenium supplementation had no effect on prostate cancer risk [23].…”

Section: Discussionmentioning

confidence: 99%

Status and Interrelationship of Zinc, Copper, Iron, Calcium and Selenium in Prostate Cancer

et al. 2015

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Deficiency or excess of certain trace elements has been considered as risk factor for prostate cancer. This study was aimed to detect differential changes and mutual correlations of selected trace elements in prostate cancer tissue versus benign prostatic hyperplasia tissue. Zinc, copper, iron, calcium and selenium were analysed in histologically proven 15 prostate cancer tissues and 15 benign prostatic hyperplasia tissues using atomic absorption spectrophotometer. Unpaired two tailed t test/MannWhitney U test and Pearson correlation coefficient were used to compare the level of trace elements, elemental ratios and their interrelations. As compared to benign prostatic tissue, malignant prostatic tissue had significantly lower selenium (p = 0.038) and zinc (p = 0.043) concentrations, a lower zinc/iron ratio (p = 0.04) and positive correlation of selenium with zinc (r = 0.71, p = 0.02) and iron (r = 0.76, p = 0.009). Considerably divergent interrelationship of elements and elemental ratios in prostate cancer versus benign prostatic hyperplasia was noted. Understanding of differential elemental changes and their interdependence may be useful in defining the complex metabolic alterations in prostate carcinogenesis with potential for development of element based newer diagnostic, preventive and therapeutic strategies. Further studies may be needed to elucidate this complex relationship between trace elements and prostate carcinogenesis.

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“…that the selenium do not lower the incidence of prostate cancer which is opposite to the result of the NPC trial, it's too early to conclude that the selenium is not preventive to prostate cancer because Hurst et al found a decreased risk of prostate cancer appears to be associated with a relatively narrow range of selenium status from a systematic review and meta-analysis (Hurst et al, 2012). The differences among the 3 trials above which might be the potential influence to the results are worthy to discuss.…”

Section: 2181 Review Of Selenium Trials For Prostate Cancer Preventionmentioning

confidence: 99%

Review of Selenium and Prostate Cancer Prevention

Yang

Mouracadé²,

Wu³

2013

Asian Pacific Journal of Cancer Prevention

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Prostate cancer is the most common malignancy in men in the United States. Surgery or radiation are sometimes unsatisfactory treatments because of the complications such as incontinence or erectile dysfunction. Selenium was found to be effective to preven prostate cancer in the Nutritional Prevention of Cancer Trial (NPC), which motivated two other clinical trials: the Selenium and Vitamin E Cancer Prevention Trial (SELECT) and a Phase III trial of selenium to prevent prostate cancer in men with high-grade prostatic intraepithelial neoplasia. However, these two trials failed to confirm the results of the NPC trial and indicated that the selenium may not be preventive of prostate cancer. In this article we review the three clinical trials and discuss some different points which might be potential factors underlying variation in results obtained.

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Selenium and prostate cancer: systematic review and meta-analysis

Abstract: The relation between selenium status and decreased prostate cancer risk was examined over a relatively narrow range of selenium status; further studies in low-selenium populations are required.

Cited by 131 publications

References 87 publications

Selenium biochemistry and its role for human health

Selenium biochemistry and its role for human health

Status and Interrelationship of Zinc, Copper, Iron, Calcium and Selenium in Prostate Cancer

Review of Selenium and Prostate Cancer Prevention

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