Review of Selenium and Prostate Cancer Prevention

Yang, Lei; Mouracadé, Pascal; Wu, Xiaohou

doi:10.7314/apjcp.2013.14.4.2181

Cited by 11 publications

(6 citation statements)

References 20 publications

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“…Though supplementation with selenium has obtained some beneficial effects during these cases, current findings are not conclusive enough and are sometimes inconsistent. For example, both the Selenium and Vitamin E Cancer Prevention Trial (SELECT) and a Phase III trial of selenium have failed to confirm the effective role of selenium in prostate cancer prevention from the Nutritional Prevention of Cancer Trial (NPC) results [ 51 ]. The disparate results of these trials may be explained by the U-shaped relationship between selenium status and protection from cancer [ 7 ].…”

Section: Associations Of Selenof and Disease Pathologiesmentioning

confidence: 99%

Role of Selenoprotein F in Protein Folding and Secretion: Potential Involvement in Human Disease

Ren

Liu

et al. 2018

Nutrients

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Selenoproteins form a group of proteins of which its members contain at least one selenocysteine, and most of them serve oxidoreductase functions. Selenoprotein F (SELENOF), one of the 25 currently identified selenoproteins, is located in the endoplasmic reticulum (ER) organelle and is abundantly expressed in many tissues. It is regulated according to its selenium status, as well as by cell stress conditions. SELENOF may be functionally linked to protein folding and the secretion process in the ER. Several studies have reported positive associations between SELENOF genetic variations and several types of cancer. Also, altered expression levels of SELENOF have been found in cancer cases and neurodegenerative diseases. In this review, we summarize the current understanding of the structure, expression, and potential function of SELENOF and discuss its possible relation with various pathological processes.

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Section: Associations Of Selenof and Disease Pathologiesmentioning

confidence: 99%

Role of Selenoprotein F in Protein Folding and Secretion: Potential Involvement in Human Disease

Ren

Liu

et al. 2018

Nutrients

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“…An example of the controversial health benefits is the supplementation with selenium for cancer prevention. Selenium was found to prevent prostate cancer in the Nutritional Prevention of Cancer Trial (NPC); these results prompted two additional clinical trials: the Selenium and Vitamin E Cancer Prevention Trial (SELECT) and a Phase III trial, which failed to confirm the results of the NPC trial, and not only demonstrated the inefficacy of these dietary supplements in preventing prostate cancer, but also reported a 17% increased risk in men taking the antioxidant compared to those taking the placebo [188]. …”

Section: Role Of Lifestyle In the Oxidative Stress Response For Hementioning

confidence: 99%

Exploring the Role of Genetic Variability and Lifestyle in Oxidative Stress Response for Healthy Aging and Longevity

Dato

Crocco

D’Aquila

et al. 2013

IJMS

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Oxidative stress is both the cause and consequence of impaired functional homeostasis characterizing human aging. The worsening efficiency of stress response with age represents a health risk and leads to the onset and accrual of major age-related diseases. In contrast, centenarians seem to have evolved conservative stress response mechanisms, probably derived from a combination of a diet rich in natural antioxidants, an active lifestyle and a favorable genetic background, particularly rich in genetic variants able to counteract the stress overload at the level of both nuclear and mitochondrial DNA. The integration of these factors could allow centenarians to maintain moderate levels of free radicals that exert beneficial signaling and modulator effects on cellular metabolism. Considering the hot debate on the efficacy of antioxidant supplementation in promoting healthy aging, in this review we gathered the existing information regarding genetic variability and lifestyle factors which potentially modulate the stress response at old age. Evidence reported here suggests that the integration of lifestyle factors (moderate physical activity and healthy nutrition) and genetic background could shift the balance in favor of the antioxidant cellular machinery by activating appropriate defense mechanisms in response to exceeding external and internal stress levels, and thus possibly achieving the prospect of living a longer life.

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“…These preclinical evidence, as well as findings from the Linxian trials, suggested the role of selenium and vitamin E in prostate cancer prevention. There is good evidence of protective effects of selenium against prostate cancer (Karimi et al, 2012;Yang et al, 2013).…”

Section: Vitamin Ementioning

confidence: 99%

Prevention of Prostate Cancer with Vitamins - Current Perspectives

Dalela¹,

Goel²,

Kumar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Cancer prostate is the most common solid malignancy in males of developed countries. With increasing knowledge of the aetiology, pathogenesis and natural history of the disease, influences of dietary factors on prostate cancer development have become more evident. There is ample evidence in the literature of significance of dietary constituents for prostate cancer including vitamins A, D and E. Different vitamins have been found to effect the growth and proliferation of prostate cancer cells as evident in epidemiological, experimental and clinical studies. Various factors play the major role in determining the relationship between these vitamins and prostate cancer in terms of environmental, pharmacological, or genetic aspects. To explore these aspects, the present article reviews the literature on the present status of vitamin use for prevention and management of prostate cancer. Keywords, Prostate cancer -vitamins A -vitamin D -vitamin E MINI-REVIEW Prevention of Prostate Cancer with Vitamins -Current PerspectivesManish Garg*, Divakar Dalela, Apul Goel, Manoj Kumar, Satya Narayan Sankhwar Literature SurveyA PubMed search was conducted with the key words 'prostate cancer'; prevention in prostate cancer; 'epidemiology factors'; 'vitamins and prostate cancer'. The specific role of vitamins was searched in prevention of prostate cancer as 'vitamins A'; 'vitamin D'; 'vitamin E. In addition, the 'related articles' search option on PubMed and references of relevant articles were also looked for with knowledge of epidemiological and other experimental study. At the end of literature research, the most relevant articles were selected for the discussion of role of vitamins in cancer prostate in this review. Vitamin AVitamin A and Retinoids, the natural or synthetic derivatives of vitamin A, demonstrated the effects on proliferation and differentiation in different organs and deficiency of this vitamin resulted in multiple developmental defects (Clagett-Dame DeLuca, 2002;Duester, 2008). Important metabolites of vitamin A (retinol) are All trans-retinoic acid (ATRA) and 9-CisRetinoic Acid (9-CRA) and both of these have diverse physiological functions in the body (Duester, 2008). These retinoids, in carcinogen induced prostate cancer mouse models, have been shown to reverse hyperplasia (Chopra

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Review of Selenium and Prostate Cancer Prevention

Cited by 11 publications

References 20 publications

Role of Selenoprotein F in Protein Folding and Secretion: Potential Involvement in Human Disease

Role of Selenoprotein F in Protein Folding and Secretion: Potential Involvement in Human Disease

Exploring the Role of Genetic Variability and Lifestyle in Oxidative Stress Response for Healthy Aging and Longevity

Prevention of Prostate Cancer with Vitamins - Current Perspectives

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