Role of Selenoprotein F in Protein Folding and Secretion: Potential Involvement in Human Disease

Ren, Bingyu; Liu, Min; Ni, Jiazuan; Tian, Jichun

doi:10.3390/nu10111619

Cited by 41 publications

(33 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, several other lines of evidence suggest that SELENOF may act as an Se-dependent oncogenic protein. SELENOF can be regulated by both Se status (as indicated also in our study) and endoplasmic reticulum (ER) stress, and several SELENOF genetic variants have been associated with an altered risk at the different cancer sites, including CRC [ 8 , 29 ]. Notably, previous cell and mouse-model studies suggest that higher levels of SELENOF may potentially contribute to favorable growth conditions for the cancerous cells in the colorectum, by reducing cellular ER stress and nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB) activation [ 29 , 30 , 31 ].…”

Section: Discussionmentioning

confidence: 71%

Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer

et al. 2018

View full text Add to dashboard Cite

Dietary selenium (Se) intake is essential for synthesizing selenoproteins that are important in countering oxidative and inflammatory processes linked to colorectal carcinogenesis. However, there is limited knowledge on the selenoprotein expression in colorectal adenoma (CRA) and colorectal cancer (CRC) patients, or the interaction with Se status levels. We studied the expression of seventeen Se pathway genes (including fifteen of the twenty-five human selenoproteins) in RNA extracted from disease-normal colorectal tissue pairs, in the discovery phase of sixty-two CRA/CRC patients from Ireland and a validation cohort of a hundred and five CRC patients from the Czech Republic. Differences in transcript levels between the disease and paired control mucosa were assessed by the Mann-Whitney U-test. GPX2 and TXNRD3 showed a higher expression and GPX3, SELENOP, SELENOS, and SEPHS2 exhibited a lower expression in the disease tissue from adenomas and both cancer groups (p-values from 0.023 to <0.001). In the Czech cohort, up-regulation of GPX1, SELENOH, and SOD2 and down-regulation of SELENBP1, SELENON, and SELENOK (p-values 0.036 to <0.001) was also observed. We further examined the correlation of gene expression with serum Se status (assessed by Se and selenoprotein P, SELENOP) in the Irish patients. While there were no significant correlations with both Se status markers, SELENOF, SELENOK, and TXNRD1 tumor tissue expression positively correlated with Se, while TXNRD2 and TXNRD3 negatively correlated with SELENOP. In an analysis restricted to the larger Czech CRC patient cohort, Cox regression showed no major association of transcript levels with patient survival, except for an association of higher SELENOF gene expression with both a lower disease-free and overall survival. Several selenoproteins were differentially expressed in the disease tissue compared to the normal tissue of both CRA and CRC patients. Altered selenoprotein expression may serve as a marker of functional Se status and colorectal adenoma to cancer progression.

show abstract

Section: Discussionmentioning

confidence: 71%

Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer

et al. 2018

View full text Add to dashboard Cite

show abstract

“…There are some selenoproteins, localized to the endoplasmic reticulum, which perform regulatory function in protein folding. This group include following selenoproteins: SelF, SelM, SelN, SelK, SelT, SelS and ID2 [11,43]. For example, SelF ensures quality of disulfide bonds formation during folding process due to interplay with UDP-glucose:glycoprotein glucosyltransferase [11].…”

Section: Selenium Status and Its Biological Importance: Selenium In Tmentioning

confidence: 99%

Selenium Anticancer Properties and Impact on Cellular Redox Status

et al. 2020

View full text Add to dashboard Cite

(1) Background: In this review, we provide information published in recent years on the chemical forms, main biological functions and especially on antioxidant and prooxidant activities of selenium. The main focus is put on the impact of selenoproteins on maintaining cellular redox balance and anticancerogenic function. Moreover, we summarize data on chemotherapeutic application of redox active selenium compounds. (2) Methods: In the first section, main aspects of metabolism and redox activity of selenium compounds is reviewed. The second outlines multiple biological functions, asserted when selenium is incorporated into the structure of selenoproteins. The final section focuses on anticancer activity of selenium and chemotherapeutic application of redox active selenium compounds as well. (3) Results: optimal dietary level of selenium ensures its proper antioxidant and anticancer activity. We pay special attention to antioxidant activities of selenium compounds, especially selenoproteins, and their importance in antioxidant defence. It is worth noting, that data on selenium anticancer properties is still contraversive. Moreover, selenium compounds as chemotherapeutic agents usually are used at supranutritional doses. (4) Conclusions: Selenium play a vital role for many organism systems due to its incorporation into selenoproteins structure. Selenium possesses antioxidant activity at optimal doses, while at supranutritional doses, it displays prooxidant activity. Redox active selenium compounds can be used for cancer treatment; recently special attention is put to selenium containing nanoparticles.

show abstract

“…In addition to Gpxs 1, 3 and 4, our results also revealed a relatively lower expression of Selenof in response to a low-Se diet, whereas its expression was significantly higher in both Se-adequate and Se-supplemented groups. As a "thioredoxin-like" selenoprotein, SELENOF is believed to perform oxidoreductase roles and is differentially expressed under adaptive and acute cellular stress conditions and changes to the Se levels [101][102][103]. It has been shown that, as an ER-resident selenoprotein, SELENOF is implicated in unfolded protein response (UPR), protecting the accumulation of unfolded or misfolded proteins in ER and thereby mitigating ER stress in cells [101].…”

Section: Expression Of Gpx1 Gpx3 Gpx4 Selenof Bcl-2 and P21mentioning

confidence: 99%

“…In any case, these findings reasonably highlight that expression of Selenof is regulated in a tissue-specific manner and responds differentially to Se levels. Our understanding of the regulation of this selenoprotein, both at transcriptional and translational levels, in different stress-related and pathologic conditions [102,103] is insufficient and further focused studies will help understand its physiological function in detail.…”

Section: Expression Of Gpx1 Gpx3 Gpx4 Selenof Bcl-2 and P21mentioning

confidence: 99%

Dietary Selenium Supplementation Ameliorates Female Reproductive Efficiency in Aging Mice

et al. 2019

View full text Add to dashboard Cite

Female reproductive (ovarian) aging is distinctively characterized by a markedly reduced reproductive function due to a remarkable decline in quality and quantity of follicles and oocytes. Selenium (Se) has been implicated in playing many important biological roles in male fertility and reproduction; however, its potential roles in female reproduction, particularly in aging subjects, remain poorly elucidated. Therefore, in the current study we used a murine model of female reproductive aging and elucidated how different Se-levels might affect the reproductive efficiency in aging females. Our results showed that at the end of an 8-week dietary trial, whole-blood Se concentration and blood total antioxidant capacity (TAOC) were significantly reduced in Se-deficient (0.08 mg Se/kg; Se-D) mice, whereas both of these biomarkers were significantly higher in inorganic (0.33 mg/kg; ISe-S) and organic (0.33 mg/kg; OSe-S) Se-supplemented groups. Similarly, compared to the Se-D group, Se supplementation significantly ameliorated the maintenance of follicles and reduced the rate of apoptosis in ovaries. Meanwhile, the rate of in vitro-produced embryos resulting from germinal vesicle (GV) oocytes was also significantly improved in Se-supplemented (ISe-S and OSe-S) groups compared to the Se-D mice, in which none of the embryos developed to the hatched blastocyst stage. RT-qPCR results revealed that mRNA expression of Gpx1, Gpx3, Gpx4, Selenof, p21, and Bcl-2 genes in ovaries of aging mice was differentially modulated by dietary Se levels. A considerably higher mRNA expression of Gpx1, Gpx3, Gpx4, and Selenof was observed in Se-supplemented groups compared to the Se-D group. Similarly, mRNA expression of Bcl-2 and p21 was significantly lower in Se-supplemented groups. Immunohistochemical assay also revealed a significantly higher expression of GPX4 in Se-supplemented mice. Our results reasonably indicate that Se deficiency (or marginal levels) can negatively impact the fertility and reproduction in females, particularly those of an advancing age, and that the Se supplementation (inorganic and organic) can substantiate ovarian function and overall reproductive efficiency in aging females.

show abstract

Role of Selenoprotein F in Protein Folding and Secretion: Potential Involvement in Human Disease

Cited by 41 publications

References 62 publications

Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer

Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer

Selenium Anticancer Properties and Impact on Cellular Redox Status

Dietary Selenium Supplementation Ameliorates Female Reproductive Efficiency in Aging Mice

Contact Info

Product

Resources

About