Selenium and coronary heart disease: a meta-analysis

Abstract

Selenium concentrations were inversely associated with coronary heart disease risk in observational studies. Because observational studies have provided misleading evidence for other antioxidants, the validity of this association is uncertain. Few randomized trials have addressed the cardiovascular efficacy of selenium supplementation, and their findings are still inconclusive. Evidence from large ongoing trials is needed to establish low selenium concentrations as a cardiovascular disease risk factor. Currently, selenium supplements should not be recommended for cardiovascular disease prevention.

Selenium biochemistry and its role for human health

“…155 Two meta-analyses observational studies were also conducted on blood, serum/plasma or toenail Se levels and compared with the incidence of coronary heart disease (CHD); a moderate inverse correlation between total Se concentration and CHD risk was found. 156,157 However, a clear causal connection cannot be inferred under the observed differences, mainly because of the potential confounding effect of the other co-supplemented antioxidants. Similar shortcomings also affect randomized trials carried out to assess the effects of Se supplementation on CHD, 156 as well as most of the studies in the literature.…”

“…156,157 However, a clear causal connection cannot be inferred under the observed differences, mainly because of the potential confounding effect of the other co-supplemented antioxidants. Similar shortcomings also affect randomized trials carried out to assess the effects of Se supplementation on CHD, 156 as well as most of the studies in the literature. 158 Apart from possible preventive actions, Se-proteins may play a more evident role in cellular defence against ROS production during or after the development of CVD.…”

Symposium on ‘Geographical and geological influences on nutrition’ Factors controlling the distribution of selenium in the environment and their impact on health and nutrition

“…Gao et al (71) CHD A meta-analysis of twenty-five observational studies shows that a 50 % increase in Se concentrations is associated with a 24 % reduction in CHD Flores-Mateo et al (72) Fertility and reproduction…”

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“…• Selenio:el exceso de selenio determinaría una elevación de 4,3 mm Hg de la sistólica y 1,6 mm Hg de la diastólica, así como una mayor incidencia de dislipemia y diabetes 82 .También se ha descripto una relación en U con la incidencia de eventos cardiovasculares 83 . Al igual que en tema anterior, la relevancia clínica parece no ser importante.…”