Selenium and Alzheimer's Disease: A Systematic Review

Loef, Martin; Schrauzer, G. N.; Walach, Harald

doi:10.3233/jad-2011-110414

Cited by 163 publications

(116 citation statements)

References 266 publications

Supporting

Mentioning

111

Contrasting

Unclassified

Order By: Relevance

“…A clinical picture of the disease is manifested by progressive loss of memory and speech as well as by cognition and behavioural deficits [99]. According to the classical hypothesis, the neurotoxic effect of Aβ is mediated by excessive free radical liberation and disturbances in Ca 2+ homeostasis [96,100]. An imbalance between free radical formation and efficiency of the antioxidant system is responsible for the widespread occurrence of protein and lipid oxidation, nucleic acid damage and mitochondrial abnormalities [99].…”

Section: Alzheimer's Diseasementioning

confidence: 99%

Selenium in the therapy of neurological diseases. Where is it going?

Dominiak¹,

Wilkaniec²,

Wroczyński³

et al. 2015

View full text Add to dashboard Cite

Selenium ( 34 Se), an antioxidant trace element, is an important regulator of brain function. These beneficial properties that Se possesses are attributed to its ability to be incorporated into selenoproteins as an amino acid. Several selenoproteins are expressed in the brain, in which some of them, e.g. glutathione peroxidases (GPxs), thioredoxin reductases (TrxRs) or selenoprotein P (SelP), are strongly involved in antioxidant defence and in maintaining intercellular reducing conditions. Since increased oxidative stress has been implicated in neurological disorders, including Parkinson's disease, Alzheimer's disease, stroke, epilepsy and others, a growing body of evidence suggests that Se depletion followed by decreased activity of Se-dependent enzymes may be important factors connected with those pathologies. Undoubtedly, the remarkable progress that has been made in understanding the biological function of Se in the brain has opened up new potential possibilities for the treatment of neurological diseases by using Se as a potential drug. However, further research in the search for optimal Se donors is necessary in order to achieve an effective and safe therapeutic income.

show abstract

Section: Alzheimer's Diseasementioning

confidence: 99%

Selenium in the therapy of neurological diseases. Where is it going?

Dominiak¹,

Wilkaniec²,

Wroczyński³

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Finally, relationships between Alzheimer's disease and several protective elements have also been established. In this sense, it has been demonstrated that a negative correlation exists between cognitive impairment and levels of selenium, as well as the activity of different selenoproteins, in patients affected by AD [22]. Furthermore, it has been described that zinc might play a neuroprotective role against Aβ-induced cytotoxicity due to its antioxidant properties [23].…”

Section: The Biological Importance Of Metalsmentioning

confidence: 99%

“…However, the exact role of these elements in pathogenesis of AD is still unknown. Numerous authors have also demonstrated a negative correlation between cognitive impairment and levels of selenium, as well as the activity of different selenoproteins, in patients affected by AD [22]. Thus, although results from selenium analysis in brain tissue are inconclusive [24,[49][50][51], levels of this metalloid in blood serum and plasma are usually decreased [26-27, 32, 36, 52-53], which could be indicative of a protective response against oxidative stress.…”

Section: The Biological Importance Of Metalsmentioning

confidence: 99%

Size Fractionation of Metal Species from Serum Samples for Studying Element Biodistribution in Alzheimer’s Disease

González‐Domínguez

2017

Neuromethods

View full text Add to dashboard Cite

This work considers the development of a novel analytical procedure for rapid and simple size fractionation of metal species from human serum samples, with a great potential for studying characteristic abnormalities of metal homeostasis associated with Alzheimer's disease and other neurodegenerative disorders. For this purpose, serum samples are subjected to protein precipitation under non-denaturing conditions, taking special care for maintaining the integrity of metal-biomolecule bindings and for preventing species transformation, and then both the supernatant (low molecular mass fraction) and the precipitate (high molecular mass fraction) are analyzed by ICP-MS in order to determine the biodistribution of serum trace elements. This methodology is validated for 11 trace elements, including aluminum, cadmium, cobalt, chromium, copper, iron, manganese, molybdenum, selenium, vanadium, and zinc, in terms of sensitivity, selectivity, accuracy, and precision.

show abstract

“…It could provide the neuroprotection against traumatic brain injury and could modulate the oxidative stress and cytokine values [101][102][103] . It's essential role has been reported in Alzheimer's and cognitive impairment [104][105][106] .…”

Section: (B) Exogenous Antioxidants In Neurodegenerative Diseasesmentioning

confidence: 99%

Antioxidants as a preventive therapeutic option for age related neurodegenerative diseases

Singh

2015

Ther Targets Neurol Dis

View full text Add to dashboard Cite

Neurodegenerative diseases: an overview -Neurodegenerative disease term illustrate a range of conditions in which primarily neurons get affected or die. Neurons are the building blocks of the central and peripheral nervous system. Neurons could not reproduce or replace themselves with age therefore, when they get damaged or die they cannot be replaced and lead to specific neurodegenerative disease. Few evidences for the presence of stem cells are reported [1] but still it is not understood whether damaged neuron could regenerate or not. The Parkinson's, Alzheimer's, and Huntington's diseases are the most prevalent age related neurodegenerative diseases of central nervous system involving death of specific neuronal population. The treatment of these neurodegenerative diseases might involve the re-supplementation of specific neuronal population with the help of stem cells but researchers and clinicians did not get noticeable success in this approach yet. Millions of people each year are getting affected by these neurodegenerative diseases and the incidences are increasing further significantly with the extended life expectancy. It has been reported by World Health Organisation (2006) that the number of older people of more than 65 years age are expected to increase to approximately 1 billion in 2030 worldwide. Developing countries like India and China will see the largest increase in numbers of aged persons. Therefore the percentage of aged population in developing countries would increase from 59% to 71% worldwide [2] . Since occurrence of most of the neurodegenerative Advances in our understanding for neurodegenerative mechanisms have increased significantly in last few decades. But still no novel disease modifying therapy has been developed which could prevent the disease progression and drawn our attention towards the development of new alternative therapy. The major obstacle for the development of disease therapy is incomplete knowledge about neurodegenerative mechanisms. Due to the insufficient information about neurodegenerative mechanisms no standard diagnostic tests for the detection of neurodegenerative disease could be develop to date, causes delayed diagnosis and disease worsening. So far the exploratory reports and clinical data have suggested the involvement of oxidative stress, mitochondrial impairment and apoptosis as major neurodegenerative mechanisms. Investigations have elicited that once initiated the degeneration of neurons could not be arrested therefore in the scarcity of curative therapy we should approach for the preventive neurodegenerative therapy. Since oxidative stress has noteworthy involvement in neuronal death solely, and in connection to other death pathways therefore, antioxidants as preventive therapeutics might provide beneficial effects in age related neurodegenerative diseases. With this hypothesis in this review we are discussing about the use of antioxidants as a preventive treatment of neurodegenerative diseases. Such therapies may work in the preventive phase or in curati...

show abstract

Selenium and Alzheimer's Disease: A Systematic Review

Cited by 163 publications

References 266 publications

Selenium in the therapy of neurological diseases. Where is it going?

Selenium in the therapy of neurological diseases. Where is it going?

Size Fractionation of Metal Species from Serum Samples for Studying Element Biodistribution in Alzheimer’s Disease

Antioxidants as a preventive therapeutic option for age related neurodegenerative diseases

Contact Info

Product

Resources

About