Selenium Ameliorate Peripheral Nerve Ischemic-Reperfusion Injury via Decreased TNF-α

Zendedel, Abolfazl; Gharibi, Z Zandi Dareh; Anbari, Khatereh; Abbaszadeh, Abolfazl; khayat, Zahra Khanipour; Khorramabadi, Reza Mohammadrezaei; Soleymaninejad, Maryam; Gholami, Mohammadreza

doi:10.1007/s12011-016-0836-7

Cited by 17 publications

(15 citation statements)

References 28 publications

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“…Recent reports indicate the importance of peripheral OFR production in the oxidative peripheral nerve injuries . However, it is well known that nociceptive processing involves additional tissues including brain and injuries are triggered via neurogenic muscle atrophy and blood damage following a peripheral nerve injury, affecting several neural networks, plasma components and muscle metabolisms . In addition to oxidative stress, apoptotic and inflammatory pathways are activated by induction of sciatic nerve injury (SNI), and the inhibition of these pathways has great interest in treatment of primary and secondary complications of SNI in brain, soleus muscle and blood .…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3]7] However, it is well known that nociceptive processing involves additional tissues including brain and injuries are triggered via neurogenic muscle atrophy and blood damage following a peripheral nerve injury, affecting several neural networks, plasma components and muscle metabolisms. [3][4][5]8,9] In addition to oxidative stress, apoptotic and inflammatory pathways are activated by induction of sciatic nerve injury (SNI), and the inhibition of these pathways has great interest in treatment of primary and secondary complications of SNI in brain, soleus muscle and blood. [5,8,9] Therefore, there is a general belief that OFR-induced lipid peroxidation, inflammation and apoptosis in tissues of experimental animals and patients with SNI may play an important role, [4,9] although the patient has not been detail clarified yet.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5]8,9] In addition to oxidative stress, apoptotic and inflammatory pathways are activated by induction of sciatic nerve injury (SNI), and the inhibition of these pathways has great interest in treatment of primary and secondary complications of SNI in brain, soleus muscle and blood. [5,8,9] Therefore, there is a general belief that OFR-induced lipid peroxidation, inflammation and apoptosis in tissues of experimental animals and patients with SNI may play an important role, [4,9] although the patient has not been detail clarified yet.…”

Section: Introductionmentioning

confidence: 99%

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Hypericum perforatum L. supplementation protects sciatic nerve injury-induced apoptotic, inflammatory and oxidative damage to muscle, blood and brain in rats

Nazıroğlu

Sönmez

2017

Journal of Pharmacy and Pharmacology

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hypericum perforatum L. supplementation protects sciatic nerve injury-induced apoptotic, inflammatory and oxidative damage to muscle, blood and brain in rats

Nazıroğlu

Sönmez

2017

Journal of Pharmacy and Pharmacology

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“…NF-kB is recognized as a transcription factor that regulates the expression of inflammatory cytokines including tumor necrosis factor (TNF)-a and interleukin (IL)-6 (Gillani et al;Sahebkar et al, 2016). These inflammatory proteins specifically TNF-α has a critical role in the development of damage caused by skeletal muscles Ischemia-reperfusion (IR) Zendedel et al, 2017). TNF-α as an inflammatory cytokine in has been distributed different organs.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Honey, Apis mellifera Meda Skorikov, on Ischemia-Reperfusion Induced Muscle Injury

et al. 2020

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GHOLAMI, M. R.; ABBASZADEH, A.; ANBARI, K.; KHAKSARIAN, M.; SHABOONI, F.; KHAYAT, Z. K.; KHORRAMABADI, R. M. & GHARRAVI, A. M. Protective effects of honey, Apis mellifera meda skorikov, on ischemia-reperfusion induced muscle injury. Int. J. Morphol., 38(3):804-810, 2020. SUMMARY:Honey is a natural antioxidant that its protective effects have been proven against ischemia-reperfusion (IR) injury. The aim of this study was to evaluate the ameliorative effect of Persian Honey, Apis mellifera meda skorikov, on gastrocnemius muscle IR injury. Eighty adult male Sprague-Dawley rats weighing 250-300 g were used. They were divided into ten groups (N=8 per group). The ischemia was conducted with a silk suture 6-0 using the slipknot technique. All groups were rendered in ischemic for 3 h, and reperfused for various times of 3 days (3-day reperfusion), 7 days (7-day reperfusion), 14 days (14-day reperfusion), and 28 days (28-day reperfusion). Half of the groups had experimental honey (5 %) treatment immediately after ischemia. After reperfusion, the rats, based on the grouping, were killed with high doses of anesthetic, and the gastrocnemius muscles were removed and fixed. After the tissue processing, the evaluation of edema and mast cells infiltration was performed with hematoxylin-eosin and toluidine blue staining, respectively. TNF-α was detected with immunohistochemistry method. The amount of TNF-α as an index of acute inflammatory except the 3rd day significantly decreased on the other day of reperfusion ( 7th , 14 7th and 28 7th days). The mast cells infiltration was significantly decreased on 7 7th and 14 7th days. The tissue edema was decreased significantly in honey administrated group in the comparison with placebo groups. Honey administration can reduce damage caused by ischemia-reperfusion in the rat gastrocnemius muscle. GHOLAMI, M. R.; ABBASZADEH, A.; ANBARI, K.; KHAKSARIAN, M.; SHABOONI, F.; KHAYAT, Z. K.; KHORRAMABADI, R. M. & GHARRAVI, A. M. Protective effects of honey,Apis mellifera meda skorikov, on ischemia-reperfusion induced muscle injury. Int. J. Morphol., 38(3):804-810, 2020.

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“…When NF-κB is activated, the expression of some of inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) is regulated. TNF-α has the potential to increase damage caused by IR (Sahebkar, Cicero, Simental-Mendía, Aggarwal, & Gupta, 2016;Zendedel et al, 2016). Antioxidants, in particular natural antioxidants, suppress oxidative stress and subsequent inflammatory responses (Alipour et al, 2011;Gholami et al, 2008;Gholami et al, 2007;Gholami et al, 2015;Li, Shen, & Luo, 2016).…”

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confidence: 99%

Quercetin postconditioning attenuates gastrocnemius muscle ischemia/reperfusion injury in rats

Khorramabadi

Anbari

Salahshoor

et al. 2020

Journal Cellular Physiology

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Quercetin, an antioxidant derived from plants, can play a beneficial role in the protection of various tissues against ischemia‐reperfusion injuries (IRI). The purpose of the present research was to investigate the protective effects of quercetin on gastrocnemius muscle ischemia‐reperfusion. A total of 80 adult male Wistar rats (weights: 250–300 g) were divided into ten groups (n = 8 per group). We used silk 6.0 surgical thread to create a knit to occlude the femoral artery and vein for 3 hr. The treated groups, which comprised half of each experimental group, received intraperitoneal injections of 150 mg/kg quercetin after the ischemia. Blood flow was subsequently reestablished in the reperfusion phase. The rats were kept in reperfusion for 3, 7, 14, or 28 days after which they were killed with high doses of anesthetic drugs, and the gastrocnemius muscles were removed and fixed. Tissue processing, hematoxylin and eosin and toluidine blue staining, and immunohistochemistry were used to assess tumor necrosis factor‐α (TNF‐α) and nuclear factor κB (NF‐κB) levels. A comparison between treated and untreated ischemic sites showed that on the third day of reperfusion, the severity of edema and NF‐κB level decreased significantly; on the 7th day of reperfusion, the severity of edema and the levels of TNF‐α and NF‐κB decreased significantly; and on the 14th day of reperfusion, all of the parameters showed significant decreases. On the 28th day of reperfusion, there were significantly decreased levels of TNF‐α and NF‐κB, and decreased mast cell infiltration when compared with the untreated groups. According to the results, administration of quercetin after ischemia could significantly prevent gastrocnemius muscle IRI.

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Selenium Ameliorate Peripheral Nerve Ischemic-Reperfusion Injury via Decreased TNF-α

Cited by 17 publications

References 28 publications

Hypericum perforatum L. supplementation protects sciatic nerve injury-induced apoptotic, inflammatory and oxidative damage to muscle, blood and brain in rats

Hypericum perforatum L. supplementation protects sciatic nerve injury-induced apoptotic, inflammatory and oxidative damage to muscle, blood and brain in rats

Protective Effects of Honey, Apis mellifera Meda Skorikov, on Ischemia-Reperfusion Induced Muscle Injury

Quercetin postconditioning attenuates gastrocnemius muscle ischemia/reperfusion injury in rats

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