Selenium

Hardy, Gil; Hardy, Ines

doi:10.1016/j.nut.2004.03.014

Cited by 34 publications

(7 citation statements)

References 32 publications

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“…The metabolism of Se, the associations of Se status with disease and the effects of Se supplementation show some sex-specific differences [6], [42]. It was therefore highly interesting to observe that the correlations of Se and SELENOP concentrations differ between the sexes, and that the correlation was poorest in young women.…”

Section: Discussionmentioning

confidence: 99%

Sex-specific and inter-individual differences in biomarkers of selenium status identified by a calibrated ELISA for selenoprotein P

Hybsier

Schulz²,

et al. 2017

Redox Biology

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Selenoprotein P (SELENOP) is a liver-derived transporter of selenium (Se) in blood, and a meaningful biomarker of Se status. Se is an essential trace element for the biosynthesis of enzymatically-active selenoproteins, protecting the organism from oxidative damage. The usage of uncalibrated assays hinders the comparability of SELENOP concentrations and their pathophysiological interpretation across different clinical studies. On this account, we established a new sandwich SELENOP-ELISA and calibrated against a standard reference material (SRM1950). The ELISA displays a wide working range (11.6–538.4 µg/L), high accuracy (2.9%) and good precision (9.3%). To verify whether SELENOP correlates to total Se and to SELENOP-bound Se, serum samples from healthy subjects and age-selected participants from the Berlin Aging Study II were analyzed by SELENOP-ELISA and Se quantification. SELENOP was affinity-purified and its Se content was determined from a subset of samples. There was a high correlation of total Se and SELENOP concentrations in young and elderly men, and in elderly women, but not in young women, indicating a specific sexual dimorphism in these biomarkers of Se status in young subjects. The Se content of isolated SELENOP was independent of sex and age (mean±SD: 5.4±0.5). By using this calibrated SELENOP-ELISA, prior reports on pathological SELENOP concentrations in diabetes and obesity are challenged as the reported values are outside reasonable limits. Biomarkers of Se status in clinical research need to be measured by validated assays in order to avoid erroneous data and incorrect interpretations, especially when analyzing young women. The Se content of circulating SELENOP differs between individuals and may provide some important diagnostic information on Se metabolism and status.

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Section: Discussionmentioning

confidence: 99%

Sex-specific and inter-individual differences in biomarkers of selenium status identified by a calibrated ELISA for selenoprotein P

Hybsier

Schulz²,

et al. 2017

Redox Biology

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“…Selenium has also been shown to exhibit differential uptake by the reproductive organs. While the retention rate for selenium is highly efficient in the testes [70], the female reproductive system does not appear to take up or retain significant levels of selenium [10, 11].…”

Section: Sex Differences After Selenium Supplementationmentioning

confidence: 99%

Sexual Dimorphism in Selenium Metabolism and Selenoproteins

Seale

Ogawa-Wong

Berry

2018

Free Radical Biology and Medicine

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Sexual dimorphism, the condition in which males and females in a species differ beyond the morphology of sex organs, delineates critical aspects of the biology of higher eukaryotes, including selenium metabolism. While sex differences in selenium biology have been described by several laboratories, delineation of the effects of sex in selenium function and regulation of selenoprotein expression is still in its infancy. This review encompasses the available information on sex-dependent parameters of selenium metabolism, as well as the effects of selenium on sex hormones. Gaps in the current knowledge of selenium and sex are identified and discussed.

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“…Recent studies suggest a significant role of selenium and the enzyme glutathione peroxidase in the pathogenesis of epilepsy [81,82]. Decreased activity of Se-BP1 (selenium-binding protein 1) pathognomonic for schizophrenia, with exacerbation it decreases to critical figures, and with replenishment, there is an improvement in the condition [83].…”

Section: Selenium Homeostasis In the Brainmentioning

confidence: 99%

Replacement Selenium Therapy in Acute Cerebral Damage

Savvina¹,

Nutsalova²,

Petrova³

et al. 2023

Selenium and Human Health

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The current literature covers the role of selenium in metabolic processes and the importance of correcting its level in various diseases and critical conditions, including acute cerebral damage due to severe traumatic brain injury (TBI) and sepsis-associated encephalopathy (SAE). Numerous experimental animal studies have demonstrated that selenium has protective properties and blocks the mechanisms of apoptosis, and is involved in maintaining the functional activity of neurons and inhibits astrogliosis. The study of the selenium content in the blood of patients with acute cerebral damage due to severe TBI and sepsis with verified SAE, and the development of schemes of replacement selenium therapy will improve outcomes, both in increasing survival and in reducing the resuscitation bed-day and the number of neurological deficits in the future.

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Selenium

Cited by 34 publications

References 32 publications

Sex-specific and inter-individual differences in biomarkers of selenium status identified by a calibrated ELISA for selenoprotein P

Sex-specific and inter-individual differences in biomarkers of selenium status identified by a calibrated ELISA for selenoprotein P

Sexual Dimorphism in Selenium Metabolism and Selenoproteins

Replacement Selenium Therapy in Acute Cerebral Damage

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