Selectivity in the sample preparation for the analysis of drug residues in products of animal origin using LC-MS

Berendsen, B.J.A.; Stolker, Linda; Nielen, Michel W. F.

doi:10.1016/j.trac.2012.09.019

Cited by 82 publications

(37 citation statements)

References 63 publications

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“…To prevent agglutination of the buffered extraction salts (MgSO 4 or Na 2 SO 4 ), the addition of an aliquot of water to obtain a ACN:H 2 O ratio of 1:1 is necessary. Instead of water, we added a 0.1 M Na 2 EDTA solution to enhance the recovery rates of tetracyclines by avoiding their typical chelate formation (Berendsen and Nielen 2013). The obtained results showed that only 19 of 30 substances could be detected and most of them showed unsatisfying recovery rates below 70%, indicating possible matrix interferences diminishing the ionization of the compounds, which is typical for ESI.…”

Section: Modified Quechers Approachesmentioning

confidence: 99%

Development and Validation of a Multi-class UHPLC-MS/MS Method for Determination of Antibiotic Residues in Dairy Products

2017

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In regard to the knowledge of provoking a worldwide resistance against antibiotics due to incorrect application and the resulting uptake of residues via the food chain, the European Union set maximum residue levels (MRLs) for these substances in animal derived products to protect the customers. In respect of these MRLs a multi-class UHPLC-MS/MS multiclass method has been developed for the simultaneous determination of 30 substances from different compound groups (quinolones, macrolides, lincosamides, β-lactams, sulphonamides, diamino-pyrimidine derivates and tetracyclines) in various kinds of dairy products. Since this method should be suitable for routine laboratory use, sample preparation requires an easy and fast approach to ensure high sample throughput. Therefore a sample preparation with C18EC dSPE bulk sorbent as a combination of the easy and quick sample preparation provided by QuEChERS and the clean-up principle of reversed phase SPE was applied. This method was validated for all compounds in all matrices in compliance with the requirements of Commission Decision 2002/657/EC.

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Section: Modified Quechers Approachesmentioning

confidence: 99%

Development and Validation of a Multi-class UHPLC-MS/MS Method for Determination of Antibiotic Residues in Dairy Products

2017

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“…To protect solvent is usually acidic acetonitrile (AcN), which improves their recovery (Blasco,76 Masia, Morillas & Picó, 2011)-and phase separation using a high salt content, followed 77 by dispersive SPE (dSPE), when a clean-up is required. A summary of applications 78 using QuEChERS for the analysis of multi-class veterinary drugs in products of animal 79 origin has been recently presented (Berendsen et al, 2013). For instance, QuEChERS 80 has been previously reported for the determination of quinolones in different food 81 matrices, such as bee products (Lombardo-Agüí et al, 2012) or milk 82 Gámiz-Gracia, Cruces-Blanco & García-Campaña, 2011), as well as for the multiclass 83 determination of antibiotics in different food commodities (Pereira Lopes et al, 2012a;84 Pereira Lopes et al, 2012b;Stubbings & Bigwood, 2009;Karageorgou, Myridakis, 85 Stephanou & Samanidou, 2013).…”

Section: A N U S C R I P Tmentioning

confidence: 99%

Determination of quinolones in fish by ultra-high performance liquid chromatography with fluorescence detection using QuEChERS as sample treatment

et al. 2015

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“…Simple and rapid methods stand out in this context because they are less dependent on high investments [147,148].…”

Section: Sample Preparation Techniquesmentioning

confidence: 99%

Veterinary Antibiotics in the Environment

Botelho¹,

Monteiro²,

LuizTornisielo³

2015

Emerging Pollutants in the Environment - Current and Further Implications

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In recent years, pharmaceutical pollution in the environment has been a great concern due to the potential effects on the human and animal health. Some of the most used classes such as antibiotics, which are used to prevent and treat bacterial infections and promote the growth of livestock, deserve to be highlighted since their intensive use has contaminated environmental matrices such as soil, water, sediment, plants, and animals with effects on the biota. To better understand the potential ecological risk of antibiotics in environments and to develop management strategies for these substances searching to reach the reduction of these compounds in aquatic systems, one of the most important steps is to determine the environmental concentrations of these compounds in the environments through analytical methods and evaluate their effects on the biota. The goal of this chapter is contribute with information about the effects of these compounds on the biota as well as its environmental behavior and bacterial resistance in additional to the main techniques for samples preparation and quantitative and confirmatory methods for its determination in the environment.

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Selectivity in the sample preparation for the analysis of drug residues in products of animal origin using LC-MS

Cited by 82 publications

References 63 publications

Development and Validation of a Multi-class UHPLC-MS/MS Method for Determination of Antibiotic Residues in Dairy Products

Development and Validation of a Multi-class UHPLC-MS/MS Method for Determination of Antibiotic Residues in Dairy Products

Determination of quinolones in fish by ultra-high performance liquid chromatography with fluorescence detection using QuEChERS as sample treatment

Veterinary Antibiotics in the Environment

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