Selectivity Enhancement for Petroleum Hydrocarbons Using a Smectic Liquid Crystalline Stationary Phase in Supercritical Fluid Chromatography

Chang, H.-C.; Markides, Karin E.; Bradshaw, Jerald S.; Lee, M. L.

doi:10.1093/chromsci/26.6.280

Cited by 44 publications

(4 citation statements)

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“…Considering these results, this CSP is better suited for SFC than GC. The same conclusion was earlier reported by us for another stationary phase, a smectic liquid crystalline polysiloxane, that also has a size and shape selectivity mechanism [16].…”

Section: Resultssupporting

confidence: 89%

Chromatographic evaluation of chiral (1R‐trans)‐N, N′ ‐1,2‐cyclohexylenebisbenzamide‐oligodimethylsiloxane copolymeric stationary phases for capillary supercritical fluid chromatography

Petersson

Markides

Johnson

et al. 1992

J Microcolumn Separations

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Abstract.A novel approach to the design of chiral stationary phases (CSPs) is illustrated by the synthesis and evaluation of selective and efficient copolymeric CSPs with alternating chiral (1R-trans)-N,N'-1,2-cyclohexylenebisbenzamide and achiral (oligodimethylsiloxane) blocks. These materials are shown to resolve a variety of chiral diols. Evaluation of the performance of one of these phases in GC and SFC suggests that SFC can produce higher resolution because of its lower operating temperature which facilitates solute-stationary phase interactions. The influence of different chiral (position of substitution) and achiral (chain length) blocks of the copolymer on solute retention, efficiency, chiral selectivity, and resolution were studied, as well as the reproducibility of the column preparation method.

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Section: Resultssupporting

confidence: 89%

Chromatographic evaluation of chiral (1R‐trans)‐N, N′ ‐1,2‐cyclohexylenebisbenzamide‐oligodimethylsiloxane copolymeric stationary phases for capillary supercritical fluid chromatography

Petersson

Markides

Johnson

et al. 1992

J Microcolumn Separations

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“…Unlike conventional stationary phases separating analytes based on vapor pressure and differences in solubility, liquid crystals also reflect the arrangement of molecules forming a mesophase [254]. This adds a unique molecular shape selectivity [255], enabling the separation of positional and geometric isomers with close-boiling points [256]. The first report on liquid crystals used as stationary phase in SFC dates to 1985, when new liquid crystalline polymers were synthesized to overcome challenges connected with their use in capillary columns [256].…”

Section: Unconventional Stationary Phases In Sfcmentioning

confidence: 99%

“…Thus, the coupling of liquid crystals on polysiloxane through an alkyl spacer was developed to preserve the functional groups of liquid crystals with improved efficiency and thermal stability [258]. For example, the liquid crystalline polysiloxane was tested for the separation of PAH isomers [255]. Liq-uid crystal polysiloxane stationary phases were coated on silica particles and used for the analysis of fat-soluble vitamins [259].…”

Section: Unconventional Stationary Phases In Sfcmentioning

confidence: 99%

Columns in analytical‐scale supercritical fluid chromatography: From traditional to unconventional chemistries

Plachká

Pilařová

Horáček

et al. 2023

J of Separation Science

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Within this review, we thoroughly explored supercritical fluid chromatography (SFC) columns used across > 3000 papers published from the first study carried out under SFC conditions in 1962 to the end of 2022. We focused on the open tubular capillary, packed capillary, and packed columns, their chemistries, dimensions, and trends in used stationary phases with correlation to their specific interactions, advantages, drawbacks, used instrumentation, and application field. Since the 1990s, packed columns with liquid chromatography and SFC‐dedicated stationary phases for chiral and achiral separation are predominantly used. These stationary phases are based on silica support modified with a wide range of chemical moieties. Moreover, numerous unconventional stationary phases were evaluated, including porous graphitic carbon, titania, zirconia, alumina, liquid crystals, and ionic liquids. The applications of unconventional stationary phases are described in detail as they bring essential findings required for further development of the supercritical fluid chromatography technique.

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“…Liquid crystal stationary phases have been studied widely in gas chromatography (GC) and capillary SFC [4][5][6] for molecular shape recognition. The physical properties of these liquid crystal stationary phases were very similar to liquid crystals in solution because they were only surface coated on the capillary column wall.…”

Section: Introductionmentioning

confidence: 99%

Molecular shape recognition of polycyclic aromatic hydrocarbons with a liquid‐crystal bonded phase in supercritical fluid chromatography

Jinno

Mae

Saito

et al. 1991

J Microcolumn Separations

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Abstract. The chromatographic characteristics of a liquid crystal bonded phase have been evaluated for the separation of polycyclic aromatic hydrocarbons (PAHs), especially focusing on its shape recognition capability in supercritical fluid chromatography (SFC). The results clearly indicate that the phase has a stronger molecular planarity and shape recognition capability than typical polymeric and monomeric octadecylsilica (ODs) phases because of the very ordered bonded phase structure. The recognition capability was slightly dependent on SFC conditions such as column pressure, column temperature, and mobile phase density. Modifier addition did not make a large difference on the recognition capability. The phase seems to be a very promising stationary phase in SFC because the recognition capability is slightly influenced by the SFC conditions. Selectivity enhancement for molecular shape and planarity recognition has been found in SFC compared to reversed-phase LC separations with the same stationary phase.

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Selectivity Enhancement for Petroleum Hydrocarbons Using a Smectic Liquid Crystalline Stationary Phase in Supercritical Fluid Chromatography

Cited by 44 publications

References 0 publications

Chromatographic evaluation of chiral (1R‐trans)‐N, N′ ‐1,2‐cyclohexylenebisbenzamide‐oligodimethylsiloxane copolymeric stationary phases for capillary supercritical fluid chromatography

Chromatographic evaluation of chiral (1R‐trans)‐N, N′ ‐1,2‐cyclohexylenebisbenzamide‐oligodimethylsiloxane copolymeric stationary phases for capillary supercritical fluid chromatography

Columns in analytical‐scale supercritical fluid chromatography: From traditional to unconventional chemistries

Molecular shape recognition of polycyclic aromatic hydrocarbons with a liquid‐crystal bonded phase in supercritical fluid chromatography

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