Selective voltammetric determination of electroactive neuromodulating species in biological samples using iron(II) phthalocyanine modified multi-wall carbon nanotubes paste electrode

Patrascu, Daniela; David, Iulia Gabriela; David, Vasile; Mihailciuc, Constantin; Stamatin, I.; Ciurea, Jean; Nagy, Lı́via; Nagy, Géza; Ciucu, Anton Alexandru

doi:10.1016/j.snb.2011.02.027

Cited by 41 publications

(16 citation statements)

References 40 publications

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“…The regression coefficient (R 2 ) was 0.95 and the limit of detection was 10 nM. To the best of our knowledge, the sensing ability of Co/Co‐N@NPC‐CPE was excellent, when compared to the previously reported cobalt mediated sensors for dopamine (Table ) .…”

Section: Resultsmentioning

confidence: 99%

Co/Co‐N@Nanoporous Carbon Derived from ZIF‐67: A Highly Sensitive and Selective Electrochemical Dopamine Sensor

et al. 2018

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Co/Co‐N nanoparticles incorporated nitrogen‐doped nanoporous carbon (Co/Co‐N@NPC) nanostructures were fabricated via pyrolysis of metal organic framework, ZIF‐67, under argon atmosphere. The ZIF‐67 derived Co/Co‐N@NPC modified carbon paste electrode exhibited excellent performance during electroanalysis of dopamine, displaying two linear ranges; 10 nM to 50 μM, and 50 μM–500 μM with sensitivity of 12.4±0.3 μA/μM/cm2 and11.69±0.06 μA/μM/cm2, respectively. The modified electrodes were observed to be highly selective towards dopamine even in presence of other interfering biomolecules such as ascorbic acid, glucose and uric acid. To the best of our knowledge, the sensing ability of Co/Co‐N@NPC with a lower limit of detection as 6 nM is the best compared to the previously reported cobalt mediated sensors for dopamine. Practical feasibility of the sensor was demonstrated in real sample analysis of dopamine measurement in human urine samples and dopamine hydrochloride injection samples.

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Section: Resultsmentioning

confidence: 99%

Co/Co‐N@Nanoporous Carbon Derived from ZIF‐67: A Highly Sensitive and Selective Electrochemical Dopamine Sensor

et al. 2018

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“…Non-enzymatic electrochemical sensors (also called enzyme-free or direct electrochemical sensors) have been widely used for the determination of NTs as some of them are electroactive and measuring their concentration in biological samples is of high importance for clinical diagnosis. Among these can be mentioned monoamines like dopamine, norepinephrine, serotonin [57,58,59].…”

Section: Non-enzymatic Electrochemical Sensorsmentioning

confidence: 99%

Latest Trends in Electrochemical Sensors for Neurotransmitters: A Review

Tavakolian-Ardakani

Hosu

Cristea

et al. 2019

Sensors

101

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Neurotransmitters are endogenous chemical messengers which play an important role in many of the brain functions, abnormal levels being correlated with physical, psychotic and neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's disease. Therefore, their sensitive and robust detection is of great clinical significance. Electrochemical methods have been intensively used in the last decades for neurotransmitter detection, outclassing more complicated analytical techniques such as conventional spectrophotometry, chromatography, fluorescence, flow injection, and capillary electrophoresis. In this manuscript, the most successful and promising electrochemical enzyme-free and enzymatic sensors for neurotransmitter detection are reviewed. Focusing on the activity of worldwide researchers mainly during the last ten years (2010–2019), without pretending to be exhaustive, we present an overview of the progress made in sensing strategies during this time. Particular emphasis is placed on nanostructured-based sensors, which show a substantial improvement of the analytical performances. This review also examines the progress made in biosensors for neurotransmitter measurements in vitro, in vivo and ex vivo.

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“…Carbon Nanotubes (CNTs) working electrodes have been proved beneficial helping the electron exchange reaction in redox processes of different species like DA, epinephrine, and 5-HT among other compounds [130,131]. We develop a novel assay for the enhanced electrochemical detection of low dopamine concentrations in the presence of serotonin in deproteinized serum samples based on the electrocatalytic action of Carbon Nanotubes Paste Electrodes (CNTPEs) modified with iron(II) phthalocyanine (FePc) has been investigated [132]. The developed FePc-MWCNTP electrodes were able to detect dopamine with a detection limit of 2.05·x 10 -7 M in the presence of 5-HT, comparable with data found in the literature or even better [117,127].…”

Section: Catecolaminesmentioning

confidence: 99%

Chemically Modified Electrodes in Biosensing

Ciucu¹

2014

J Biosens Bioelectron

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The development of chemical sensors has received a great deal of scientific interest in the last decades. Not only the chemical industry may benefit from these sensors but also the food industry, bio-industry, medicine, environmental control because of their capability to give continuously and reversibly a selective and fast response to the presence of a specific compound in a complex mixture of components, without perturbing the system. Biosensors combine the power of analytical detection techniques with the specificity of biological recognition system and therefore they are the most promising devices today about this selectivity. Furthermore, biosensors possess many unique features such as compact size, simplicity of use, one-step reagentless analysis, absence of radioactivity, etc., that make them very attractive alternatives to conventional bioanalytical techniques. The present short review highlights some modern aspects of Chemically Modified Electrodes (CMEs) based on redox enzymes used in amperometric biosensing, a detection method which has already found a large number of applications in health care, food industry and environmental analysis. Some relevant applications of amperometric biosensors based on CMEs to real sample analysis are also presented and some possible future trends highlighted.

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Selective voltammetric determination of electroactive neuromodulating species in biological samples using iron(II) phthalocyanine modified multi-wall carbon nanotubes paste electrode

Cited by 41 publications

References 40 publications

Co/Co‐N@Nanoporous Carbon Derived from ZIF‐67: A Highly Sensitive and Selective Electrochemical Dopamine Sensor

Co/Co‐N@Nanoporous Carbon Derived from ZIF‐67: A Highly Sensitive and Selective Electrochemical Dopamine Sensor

Latest Trends in Electrochemical Sensors for Neurotransmitters: A Review

Chemically Modified Electrodes in Biosensing

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