Selective suppression of the anaerobic oropharyngeal microflora with local metronidazole

Borthen, L.; Heimdahl, Anders; Nord, Carl Erik

doi:10.1016/0266-4356(87)90156-2

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…The oropharynx normally harbors a complex population of microflora that includes more than 300 different bacterial species. Both aerobic and anaerobic microorganisms are present, and anaerobes outnumber aerobes by a factor of 10 to one (6). Knowing this, it would seem logical to administer prophylactic antibiotics to patients undergoing third molar surgery; however, the use of antibiotics for preventing wound infection in elective surgery is controversial.…”

Section: Introductionmentioning

confidence: 99%

The value of routine antibiotic prophylaxis in mandibular third molar surgery: Acute-phase protein levels as indicators of infection.

Bulut

Etikán

et al. 2001

Journal of Oral Science

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Postoperative infections in the oral region are usually caused by anaerobic bacteria. While some authors claim that routine antibiotic prophylaxis is necessary after third molar surgery, others do not recommend this practice. The major subject of controversy is what constitutes postoperative infection. Previous studies that have examined the benefit of routine antibiotic prophylaxis have used several clinical symptoms (pain, swelling, and trismus) as indicators of infection; however, these clinical symptoms may be vague and unreliable, and cannot be evaluated scientifically. As a result, their use has only sparked more debate in this area of research. The present study assessed the value of routine antibiotic prophylaxis in impacted mandibular third molar surgery using acutephase protein levels as potential indicators of early and late postoperative infection. Specifically, serum levels of C-reactive protein and alpha-1 antitrypsin were measured preoperatively and postoperatively in patients who received either prophylactic antibiotics or placebos. The results revealed no statistically significant difference between treated and control patients in terms of incidence of postoperative infection.

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Section: Introductionmentioning

confidence: 99%

The value of routine antibiotic prophylaxis in mandibular third molar surgery: Acute-phase protein levels as indicators of infection.

Bulut

Etikán

et al. 2001

Journal of Oral Science

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“…A less rigid practice is often applied to the face and jaws due to the age-old surgical principle attributed to their profuse blood supply. However, Borthen et al (12) showed that the mouth is a heavily contaminated environment with some 300 species of organisms present, especially anaerobes. Despite good aseptic techniques and wound toilet, extraction wounds contain not only bacteria but also bone and cementum chips, squames and probably a variety of other surgical debris (13).…”

Section: Third Molar Surgerymentioning

confidence: 99%

Third Molar Surgery: The Effect of Primary Closure, Wound Dressing and Metronidazole on Postoperative Recovery

Lyall¹

1991

J R Army Med Corps

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One hundred and forty eight patients with bilateral symmetrically impacted lower third molars entered a clinical crossover trial to compare the effects on postoperative recovery of a Bismuth Iodoform Paraffin Paste (BIPP) socket dressing, primary closure using a resorbable suture (Softgut) and to ascertain if prophylactic metronidazole influenced the outcome. The results reaffirm the surgical principle that contaminated surgical wounds such as third molar sockets are best kept open with a dressing. Attempts at primary closure should be resisted if there is no intention to prescribe antibiotic cover. However, if a suitable antibiotic is taken then primary closure using a resorbable suture can be carried out with confidence. This may reduce the need for outpatient follow up.

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Antimicrobial Prophylaxis: Proceedings of the Symposium on Antimicrobial Prophylaxis. Oslo, May 4–5, 1990

Bergan¹,

Nord²

1989

Scandinavian Journal of Infectious Diseases

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Selective suppression of the anaerobic oropharyngeal microflora with local metronidazole

Cited by 4 publications

References 14 publications

The value of routine antibiotic prophylaxis in mandibular third molar surgery: Acute-phase protein levels as indicators of infection.

The value of routine antibiotic prophylaxis in mandibular third molar surgery: Acute-phase protein levels as indicators of infection.

Third Molar Surgery: The Effect of Primary Closure, Wound Dressing and Metronidazole on Postoperative Recovery

Antimicrobial Prophylaxis: Proceedings of the Symposium on Antimicrobial Prophylaxis. Oslo, May 4–5, 1990

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