Selective sorption of uric acid by novel molecularly imprinted polymers

Leshchinskaya, A. P.; Polyakova, I. V.; Groshikova, A. R.; Писарев, О. А.; Панарин, Е. Ф.

doi:10.2478/molim-2012-0003

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…UA is characterized by polyfunctional interactions with synthetic and natural polymers [14]. In this study, we used as initial matrices (CPs) copolymers with different extents of hydrophobicity, prepared at HEMA to EGMD ratios of 50 : 50 and 80 : 20 (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Previously we synthesized network polymers with UA molecular imprints from ethylene glycol dimethacrylate (EGDM) and 2-dimethylaminoethyl methacrylate (DMAEMA) [7]. It is known that the use of ionic sorbents for operation with blood plasma is undesirable [8].…”

Section: Macromolecular Compounds and Polymeric Materialsmentioning

confidence: 99%

“…It is known that the use of ionic sorbents for operation with blood plasma is undesirable [8]. In addition, the synthesized polymers showed low sorption capacity in multicomponent media (18 μmol g -1 ) [9,10]. Therefore, in this study we chose as comonomers the hemocompatible comonomers, EGDM and 2-hydroxyethyl methacrylate (HEMA) [11].…”

Section: Macromolecular Compounds and Polymeric Materialsmentioning

confidence: 99%

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Synthesis and sorption properties of polymeric sorbents molecularly imprinted with uric acid

2015

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Polymeric sorbents molecularly imprinted with a uremic toxin, uric acid, were prepared by suspension copolymerization of 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate in the presence of uric acid. The physicochemical and sorption properties of the synthesized sorbents and of the corresponding control sorbents synthesized without uric acid were studied. The infl uence of the amount of the introduced template on the structural features and sorption capacity of the synthesized polymers was determined. As compared to control sorbents, the synthesized imprinted sorbents exhibit increased equilibrium sorption capacity for uric acid.

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Section: Resultsmentioning

confidence: 99%

Section: Macromolecular Compounds and Polymeric Materialsmentioning

confidence: 99%

Section: Macromolecular Compounds and Polymeric Materialsmentioning

confidence: 99%

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Synthesis and sorption properties of polymeric sorbents molecularly imprinted with uric acid

2015

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“…However, electrochemical techniques are more preferable in this context because of their ease of handling, cost-effectiveness, and higher accuracy level to avoid any false positive signaling. Electrochemical techniques like DPV, chronoamperometry (CA), square-wave voltammetry (SWV) are powerful tools among others to carry out sensing of UA at the physiological concentration level by modifying the bare electrode with polymers (ethylene glycol, dimethacrylate, (dimethylamino)ethyl methacrylate, etc.) and biomaterials , (norepinephrine, propionylcholine, etc.).…”

Section: Introductionmentioning

confidence: 99%

Zone-Specific Crystallization and a Porosity-Directed Scaling Marker for the Catalytic Efficacy of Au–Ag Alloy Nanoparticles

Mondal

Roy

et al. 2019

ACS Appl. Nano Mater.

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Bimetallic Au–Ag hollow nanoprisms (HNPrs) with variable effective surface areas, dynamic atomic compositions (Au:Ag), and distinct stepped surfaces between the central porous region and crystalline periphery are synthesized through a modified seed-mediated growth followed by a sacrificial galvanic replacement method. Porous central-cavity-induced distortion from prism to disk shape generates an increased number of numerous low-coordinated crystal defects on the crystalline nanodisk surface along with extended d-orbital spacing of the respective crystal disorders in the central-cavity region of HNPrs to control their adsorption efficiency for different redox reactions. Among the different HNPrs, HNPr250 possesses the highest density of the grain boundary with a preferable Au0:Ag0 ratio to form an extensive porous ligamentous central cavity, acts as a superior electrocatalyst to accelerate the kinetics of the uric acid (UA) oxidation (8.4 times compared to the blank electrode), and allows us to detect UA even in the nanomolar range. Experimental observations have been supported by density functional theory calculation to approximate the effective Au–Au displacement with a suitable percentage of Ag in different HNPrs to explain their measured catalytic activity.

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“…Since the sensors involving use of enzymes are expensive and time taking, it becomes necessary to have a cost effective method for the determination of UA in biological fluids. For fabrication of selective electrode, material with selective recognition properties can be obtained by molecular imprinting technology 24.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Determination of Uric Acid Based on Molecularly Imprinted Polymer Modified Carbon Paste Electrode

et al. 2015

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Molecularly imprinted polymer (MIP) for uric acid (UA) was synthesized by thermal polymerization using acrylic acid (AA) as functional monomer, ethylene glycol dimethacrylate (EGDMA) as cross linker and 2,2′‐azobis(2‐isobutyro) nitrile (AIBN) as initiator. The noncovalent interactions involved in four possible conformations of pre‐polymer complex were computationally studied by density functional theory. The hydrogen bond formation between UA and AA was confirmed by Fourier transform infrared (FTIR) spectrum of the MIP before extraction of UA. After extraction of the template, the molecularly imprinted polymer based carbon paste electrode (MIPCPE) was fabricated under optimized conditions. A significant enhancement in the electrocatalytic oxidation of UA was found at MIPCPE. The electrochemical behavior of sensor was investigated by cyclic voltammetry (CV) and differential pulse adsorptive stripping voltammetry (DPAdSV). The electrochemical impedance spectroscopy (EIS) studies revealed less charge transfer resistance (Rct) at MIPCPE than NIPCPE. Under optimized conditions, calibration curve was obtained with a linearity range of 0.5 µM to 100 µM and the limit of detection was 0.1 µM. The sensor showed good selectivity towards UA in the presence of interferents and was successfully applied for the determination of UA in spiked serum samples.

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Selective sorption of uric acid by novel molecularly imprinted polymers

Cited by 7 publications

References 20 publications

Synthesis and sorption properties of polymeric sorbents molecularly imprinted with uric acid

Synthesis and sorption properties of polymeric sorbents molecularly imprinted with uric acid

Zone-Specific Crystallization and a Porosity-Directed Scaling Marker for the Catalytic Efficacy of Au–Ag Alloy Nanoparticles

Voltammetric Determination of Uric Acid Based on Molecularly Imprinted Polymer Modified Carbon Paste Electrode

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