Selective Sentinel Lymphadenectomy for Malignant Melanoma, Merkel Cell Carcinoma, and Squamous Cell Carcinoma

Leong, Stanley P. L.

doi:10.1007/0-387-23604-x_3

Cited by 18 publications

(4 citation statements)

References 121 publications

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“…The surgeon should master the techniques of preoperative lymphoscintigraphy and intraoperative lymphatic mapping. An SLN is defined as a blue, “hot,” and any subsequent lymph node greater than 10% of the ex vivo count of the hottest lymph node [71]. Any enlarged or indurated lymph node in the nodal basin should be excised.…”

Section: Definitive Surgerymentioning

confidence: 99%

A Practical Update of Surgical Management of Merkel Cell Carcinoma of the Skin

Tai¹

2013

ISRN Surgery

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The role of surgeons in the treatment of Merkel cell carcinoma (MCC) of the skin is reviewed, with respect to diagnosis and treatment. Most of the data in the literature are case reports. Surgery is the mainstay of treatment. A wide local excision, with sentinel node (SLN) biopsy, is the recommended treatment of choice. If SLN is involved, nodal dissection should be performed; unless patient is unfit, then regional radiotherapy can be given. Surgeons should always refer patients for assessment of the need for adjuvant treatments. Adjuvant radiotherapy is well tolerated and effective to minimize recurrence. Adjuvant chemotherapy may be considered for selected node-positive patients, as per National Comprehensive Cancer Network guideline. Data are insufficient to assess whether adjuvant chemotherapy improves survival. Recurrent disease should be treated by complete surgical resection if possible, followed by radiotherapy and possibly chemotherapy. Generally results of multimodality treatment for recurrent disease are better than lesser treatments. Future research should focus on newer chemotherapy and molecular targeted agents in the adjuvant setting and for gross disease.

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Section: Definitive Surgerymentioning

confidence: 99%

A Practical Update of Surgical Management of Merkel Cell Carcinoma of the Skin

Tai¹

2013

ISRN Surgery

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“…Two patients with positive sentinel nodes had further neck dissection to gain prognostic information for adjuvant treatment even though its effect on survival remains unclear. 16,17 In our study, 4 (23.5%) patients developed regional lymph node metastasis after sentinel node biopsy or neck dissection and one of them could be salvaged by neck dissection. Adjuvant RT should be considered for close or positive margin where re-excision is not feasible, for baseline risk factors such as large primary tumor (>2 cm), lymphovascular invasion, or profound immunosuppression, and for failed SLNB or node-positive neck.…”

Section: Discussionmentioning

confidence: 56%

Merkel Cell Carcinoma of the Head and Neck

2021

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Merkel cell carcinoma (MCC) of the head and neck is a rare and aggressive non-melanoma skin cancer. The objective of this study was to assess the oncological outcome of MCC by retrospective review of electronic and paper records of a population-based cohort of 17 consecutive cases of the head and neck MCC without distant metastasis, diagnosed in Manitoba between 2004 and 2016. The average age of the patients at initial presentation was 74.1 ± 14.4 years with 6 patients presenting with stage I, 4 with stage II, and 7 with stage III disease. Both surgery or radiotherapy alone were the primary treatment modalities in 4 patients each and the remaining 9 patients had a combination of surgery with adjuvant radiotherapy. During the median follow-up of 52 months, 8 patients had recurrent/residual disease and 7 eventually died of it ( P = .001). Metastatic spread of disease to the regional lymph nodes was observed in 11 patients either at presentation or during the follow-up and to the distant sites in 3 patients. At the time of the last contact on November 30, 2020, 4 patients were alive and disease-free, 7 had died of disease, and 6 had died of other causes. The case fatality rate was 41.2%. Five-year disease-free and disease-specific survivals were 51.8% and 59.7%, respectively. The 5-year disease-specific survival was 75% for early stage MCC (stage I and II) and 35.7% for stage III MCC. Early diagnosis and intervention are crucial for disease control and improving survival.

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“…Lymphatic mapping and sentinel node biopsy has also become very common in the high risk squamous cell carcinoma (SCC) of the skin [10,11] including SCC of the genital area [12,13].…”

Section: Literature Review and Discussionmentioning

confidence: 99%

Lymphatic mapping and sentinel node biopsy in a patient with upper limb Merkel Cell Carcinoma: a case report and brief review of literature

Kermani¹,

Rezaei²,

Zarifmahmoudi³

et al. 2016

Nucl. Med. Rev.

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Sentinel node mapping is an integral part of regional lymph node staging in many solid tumors and plays an important role in surgical oncology. This technique has been used with excellent results for non-melanoma skin cancers including Merkel Cell Carcinoma (MCC). In the current study, we reported our first MCC patient who underwent successful sentinel node mapping.We also reviewed the available literature regarding the prognostic significance of sentinel node mapping in cN0 MCC patients.

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Selective Sentinel Lymphadenectomy for Malignant Melanoma, Merkel Cell Carcinoma, and Squamous Cell Carcinoma

Cited by 18 publications

References 121 publications

A Practical Update of Surgical Management of Merkel Cell Carcinoma of the Skin

A Practical Update of Surgical Management of Merkel Cell Carcinoma of the Skin

Merkel Cell Carcinoma of the Head and Neck

Lymphatic mapping and sentinel node biopsy in a patient with upper limb Merkel Cell Carcinoma: a case report and brief review of literature

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