Selective reductions in prefrontal glucose metabolism in murderers

Raine, Adrian; Buchsbaum, Monte S.; Stanley, C.J.; Lottenberg, Stephen; Abel, Leonard; Stoddard, Jacqueline L.

doi:10.1016/0006-3223(94)91211-4

Cited by 331 publications

(137 citation statements)

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“…Earlier PET studies have also associated reduced prefrontal, particularly orbital frontal and adjacent medial frontal, cortical metabolism with aggressive behavior (Goyer et al 1994;Raine et al 1994;Volkow and Tancredi 1987). For example, one study (Goyer et al 1994) found an inverse relationship between life history of "aggressive-impulsive behavior" and regional glucose metabolism in the orbital frontal cortex (Brodmann 11) and the right temporal lobe.…”

Section: Discussionmentioning

confidence: 97%

“…Positron emission tomography (PET) has revealed reduced prefrontal cortical activity in patients with bipolar depression (Baxter et al 1989), patients with personality disorders characterized by impulsive aggression (Goyer et al 1994), alcoholic criminal offenders with a history of impulsive aggression (Linnoila et al 1983), impulsive murderers (Raine et al 1994), and violent psychiatric inpatients (Volkow and Tancredi 1987). Fenfluramine administration increases cortical metabolism and/or blood flow in orbital frontal cortex in normal subjects (Kapur et al 1994;Mann et al 1996).…”

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confidence: 99%

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d,l-fenfluramine Response in Impulsive Personality Disorder Assessed with [18F]fluorodeoxyglucose Positron Emission Tomography

Siever

Buchsbaum

New

et al. 1999

Neuropsychopharmacology

266

121

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Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

d,l-fenfluramine Response in Impulsive Personality Disorder Assessed with [18F]fluorodeoxyglucose Positron Emission Tomography

Siever

Buchsbaum

New

et al. 1999

Neuropsychopharmacology

266

121

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“…In a first study they found reduced activity circumscribed to the anterior left pre-frontal cortex while performing the Continuous Performance Task (CPT), a measure of sustained attention (Raine et al, 1994). Lower prefrontal function was found in individuals who had committed impulsive murders as opposed to planned murders.…”

Section: Brain Imaging Structure and Function In Other Antisocial Dismentioning

confidence: 99%

Neurocognitive elements of antisocial behavior: Relevance of an orbitofrontal cortex account

Séguin

2004

Brain and Cognition

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This paper reviews the role of orbitofrontal cortex (OFC) lesions in antisocial behaviors and the adequacy of a strict OFC account of antisocial disorders where there is no evidence of lesion. Neurocognitive accounts of antisocial behaviors are extended beyond the OFC. Several methodological shortcomings specific to this neuroscience approach to antisocial behavior are identified. A developmental approach is advocated to chart the developmental sequences of impaired brain development and of the various comorbid states typically seen in antisocial disorders.

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“…Studying regional brain glucose metabolism in murderers with PET, Raine and coworkers [54] found decreased activity in the prefrontal cortex in comparison to controls (see Table 1 for detailed information on studies in this area based on a MEDLINE search using the terms "tomography", "imaging", "viol*" and "aggr*"), and several other studies on offenders have documented frontal or temporal abnormalities in functioning or structure (Table 1). All these studies have been cross-sectional, and regional dysfunctions in perpetrators under the stress of a court procedure, awaiting harsh sentences, may express state rather than trait.…”

mentioning

confidence: 99%

Central nervous changes in social dysfunction: Autism, aggression, and psychopathy

Anckarsäter

2006

Brain Research Bulletin

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Neurodevelopmental disorders such as autism and schizophrenia involve social interaction problems and poor mentalizing abilities, associated with abnormal regional cerebral activity.Similar problems may be present in aggressive personality disorders and psychopathy. This paper reviews brain imaging data from research aiming at establishing possible central nervous correlates to aggression and psychopathy. Studies in this field are associated with a range of method problems. Differences between criminal offenders and controls may be confounded by a number of factors unrelated to personality traits or aggression per se.Phenotypical characterisation varies between studies as do the laboratory methods and their interpretation. In spite of these problems, there are some recurrent findings in the present literature. Hypoactivity or structural reduction of the prefrontal cortex is a consistent finding in violent offenders or subjects with antisocial personality disorder. When defined as a personality disorder of social interaction and empathy, psychopathy seems to be associated rather with central abnormalities in the limbic circuitry. Indications of an increased dopaminergic neurotransmission relative to the serotonergic have also been connected to such personality traits, especially to the AD/HD-related behavioural aspects. Further studies using strict phenotypical definitions or experimental models are clearly warranted to establish a pathophysiological background to destructive personality traits and the propensity to violent acting out.

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Selective reductions in prefrontal glucose metabolism in murderers

Cited by 331 publications

References 20 publications

d,l-fenfluramine Response in Impulsive Personality Disorder Assessed with [18F]fluorodeoxyglucose Positron Emission Tomography

d,l-fenfluramine Response in Impulsive Personality Disorder Assessed with [18F]fluorodeoxyglucose Positron Emission Tomography

Neurocognitive elements of antisocial behavior: Relevance of an orbitofrontal cortex account

Central nervous changes in social dysfunction: Autism, aggression, and psychopathy

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