Selective reduction of nitroarenes using Ru/C and CaH₂

Abstract

Herein we report an efficient and highly selective method for the reduction of aromatic, heteroaromatic and halo- nitrocompounds using the rapid available and cost-effective Ru/C as catalyst and the unconventional...

Hydrodeoxygenation of Carbonyl Compounds Biomass Derivatives Using CaH2 over Pd/C

“…Recently, we have reported the regioselective reduction of nitro aromatic and heteroaromatic compounds to the corresponding amines using Ru/C and calcium hydride (CaH 2 ) as the catalytic system. [12] During this work, we observed that 4nitrobenzaldehyde was reduced to 4-aminotoluene when Pd/C was used instead of Ru/C. The use of hydrides for the full reduction of aldehydes or ketones has been previously reported with other hydride sources such as LiAlH 4 , NaBH 4 and NaBH 3 CN in the presence of Lewis acids, [19] or in combination with PdCl 2 .…”

“…This was also the case of the electron-poor aromatic ring, pyridine-2-carboxaldehyde (entry 8), which was reduced only to the corresponding alcohol. Interestingly, however, is the fact that nitrobenzaldehydes (o, m, p) were fully reduced to the corresponding methylanilines (entries 4,11,12) with yields up to 85 %, suggesting that the nitro group is reduced first to the corresponding amine and later it would occur the HDO of the aldehyde moiety. To confirm this idea, using p-nitrobenzaldehyde, the reaction was controlled at different reaction times.…”

“…Recently, we have reported the regioselective reduction of nitro aromatic and heteroaromatic compounds to the corresponding amines using Ru/C and calcium hydride (CaH 2 ) as the catalytic system [12] . During this work, we observed that 4‐nitrobenzaldehyde was reduced to 4‐aminotoluene when Pd/C was used instead of Ru/C.…”