Selective probes targeting c-MYC Pu22 G-quadruplex and their application in live mice imaging

Selectivec-MYCG4 DNA recognition based on a fluorescent light-up probe with disaggregation-induced emission characteristics

“…21 Several probes containing benzothiazole-guided conjugated systems (BGCS) were designed and synthesized in another work, and two molecules (BGCS5 and BGCS6) were determined as selective probes for targeting c-MYC G4 DNA over other DNAs. 22 Our group reported a fluorescent probe based on a benzo[ f ]quinolinium derivative with a styryl moiety. 23 This probe exhibited great fluorescence enhancement in the presence of c-MYC G4, while moderate or low enhancement was observed with other DNAs.…”

DPA‐Substituted Carbazole Derivative as a Fluorescent Ligand for G4 DNA

“…For the synthesis of the ligand Car-DPA, 1,2-dimethylpyridin-1-ium iodide and compound 4 were refluxed in ethanol with a catalytic amount of piperidine to obtain a yellow solid power. The structures of these compounds were characterized by 1 H-NMR, 13 C-NMR, and HR-MS (ESI), as shown in Supporting Information.…”

“…Both of them were bought from Qingdao Ocean Chemicals (Qingdao, China). 1 H-and 13 C-NMR spectra were collected by employing a Bruker AM400 NMR spectrometer. High-resolution mass spectra (HR-MS) were recorded on a Shimazu LCMS-IT-TOF instrument with an ESI detector.…”

“…However, the precise mechanisms of G4 DNAs in cells remain poorly characterized. Therefore, much effort has been put into the development of effective fluorescence probes derived either from natural products or synthetic compounds [13–23] …”