Acute pancreatitis (AP) is a complex abdominal disease with high morbidity and mortality that involves a strong local and systemic inflammatory response. When AP develops into severe acute pancreatitis (SAP), it easily leads to multiple organ dysfunction syndrome, which is also one of the main reasons for death in SAP patients. [1] In the past decade, we have made substantial progress in our understanding of the pathophysiological mechanism of AP. The mechanism of calcium-mediated acinar cell damage and death has been elucidated.
c-MYC promoter is well-known as an important oncogene, whose overexpression leads to ∼80% of all solid tumors. The four-stranded G4 present in the c-MYC promoter has been shown to play...
Severe acute pancreatitis (SAP) is a potentially lethal disease with considerable morbidity and mortality. It is often accompanied by systemic inflammatory response syndrome, sepsis, and organ dysfunction. [1] It is generally believed that intestinal barrier dysfunction and bacterial translocation (BT) are the primary causes of systemic inflammation and sepsis complications in patients with SAP. [2] Recently, increasing evidence has shown that autophagy plays an important role in intestinal homeostasis. Autophagy can protect the intestinal mucosal barrier during SAP by degrading and recovering the cytoplasmic content of intestinal epithelial cells and damaged organelles, removing invading microorganisms, and participating in antigen presentation and lymphocyte development. [2,3] Therefore, regulating autophagy as a form of treatment for SAP may bring beneficial results.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.