Selective myelinated nerve fiber stimulation via temporal interfering electric fields

Wang, Gonglei; Dokos, Socrates

doi:10.1109/embc46164.2021.9630073

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…Therefore, TI electrical stimulation may not be effective on all neuron types, indicating the possibility of second-order networklevel effects of this approach. In another study, the researchers studied the selective electrical stimulation of myelinated nerve fibers of TI electrical fields (Wang and Dokos, 2021). The results showed that TI electrical stimulation could selectively stimulate myelinated nerve fibers in nerve bundles.…”

Section: Possible Mechanismsmentioning

confidence: 99%

A novel non-invasive brain stimulation technique: “Temporally interfering electrical stimulation”

Guo

He²,

Zhang³

et al. 2023

Front. Neurosci.

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For decades, neuromodulation technology has demonstrated tremendous potential in the treatment of neuropsychiatric disorders. However, challenges such as being less intrusive, more concentrated, using less energy, and better public acceptance, must be considered. Several novel and optimized methods are thus urgently desiderated to overcome these barriers. In specific, temporally interfering (TI) electrical stimulation was pioneered in 2017, which used a low-frequency envelope waveform, generated by the superposition of two high-frequency sinusoidal currents of slightly different frequency, to stimulate specific targets inside the brain. TI electrical stimulation holds the advantages of both spatial targeting and non-invasive character. The ability to activate deep pathogenic targets without surgery is intriguing, and it is expected to be employed to treat some neurological or psychiatric disorders. Recently, efforts have been undertaken to investigate the stimulation qualities and translation application of TI electrical stimulation via computational modeling and animal experiments. This review detailed the most recent scientific developments in the field of TI electrical stimulation, with the goal of serving as a reference for future research.

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Section: Possible Mechanismsmentioning

confidence: 99%