Selective laser sintering 3D printing – an overview of the technology and pharmaceutical applications

Charoo, Naseem A.; Ali, Sogra F. Barakh; Mohamed, Eman M.; Kuttolamadom, Mathew; Ozkan, Tanil; Khan, Mansoor A.; Rahman, Ziyaur

doi:10.1080/03639045.2020.1764027

Cited by 155 publications

(68 citation statements)

References 60 publications

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“…This technology produces 3D objects layer-by-layer [ 154 ] using a computer-controlled, high-power laser that selectively heats and fuses tightly compact, small powder particles such as metal, plastics, polymers, or ceramics. These particles then solidify and form a 3D structure with the desired shape and properties [ 91 , 100 , 151 , 155 ]. Direct metal laser sintering (DMLS) is an extension of the SLS process and produces 3D printed objects by sintering the powdered metals with a precise, high-intensity laser [ 154 ].…”

Section: Fabrication Of Microneedles Using 3d Printing Technologiesmentioning

confidence: 99%

“…Direct metal laser sintering (DMLS) is an extension of the SLS process and produces 3D printed objects by sintering the powdered metals with a precise, high-intensity laser [ 154 ]. The SLS and DLMS systems consist of a laser system, powder bed, and spreading platform [ 155 ]. In DLMS, the powder bed is filled with metal alloy powders such as bronze, steel, stainless steel 316 L, titanium, or Al-30% Si without a binder or fluxing agent [ 112 ].…”

Section: Fabrication Of Microneedles Using 3d Printing Technologiesmentioning

confidence: 99%

“…The 3D process starts with CAD data exported in the industry-standard exchange file format, STL [ 153 ]. Subsequently, the powder is distributed uniformly onto the building platform by using a slot feeder and a scraper blade (roller) that even the surface [ 28 , 155 ]. Sintering means that the printing process is maintained at a temperature that does not completely melt the powders, as it is below the melting point of the material, which is sufficient to enable fusion between particles at the molecular level [ 28 , 91 , 153 , 155 ].…”

Section: Fabrication Of Microneedles Using 3d Printing Technologiesmentioning

confidence: 99%

“…Subsequently, the powder is distributed uniformly onto the building platform by using a slot feeder and a scraper blade (roller) that even the surface [ 28 , 155 ]. Sintering means that the printing process is maintained at a temperature that does not completely melt the powders, as it is below the melting point of the material, which is sufficient to enable fusion between particles at the molecular level [ 28 , 91 , 153 , 155 ]. The powder bed is lowered by the thickness of one layer so that a subsequent layer of powder is loaded into the build tank and fused by the laser.…”

Section: Fabrication Of Microneedles Using 3d Printing Technologiesmentioning

confidence: 99%

“…The powder bed is lowered by the thickness of one layer so that a subsequent layer of powder is loaded into the build tank and fused by the laser. The process is repeated until the final 3D model is created ( Figure 6 ) [ 100 , 155 ]. Support during the 3D printing process is provided by unsintered powder particles present on the build platform, which are then removed by hand, a vacuum, or sieving [ 28 , 91 , 155 ].…”

Section: Fabrication Of Microneedles Using 3d Printing Technologiesmentioning

confidence: 99%

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3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery

et al. 2021

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Microneedles (MNs) represent the concept of attractive, minimally invasive puncture devices of micron-sized dimensions that penetrate the skin painlessly and thus facilitate the transdermal administration of a wide range of active substances. MNs have been manufactured by a variety of production technologies, from a range of materials, but most of these manufacturing methods are time-consuming and expensive for screening new designs and making any modifications. Additive manufacturing (AM) has become one of the most revolutionary tools in the pharmaceutical field, with its unique ability to manufacture personalized dosage forms and patient-specific medical devices such as MNs. This review aims to summarize various 3D printing technologies that can produce MNs from digital models in a single step, including a survey on their benefits and drawbacks. In addition, this paper highlights current research in the field of 3D printed MN-assisted transdermal drug delivery systems and analyzes parameters affecting the mechanical properties of 3D printed MNs. The current regulatory framework associated with 3D printed MNs as well as different methods for the analysis and evaluation of 3D printed MN properties are outlined.

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Section: Fabrication Of Microneedles Using 3d Printing Technologiesmentioning

confidence: 99%

Section: Fabrication Of Microneedles Using 3d Printing Technologiesmentioning

confidence: 99%

Section: Fabrication Of Microneedles Using 3d Printing Technologiesmentioning

confidence: 99%

Section: Fabrication Of Microneedles Using 3d Printing Technologiesmentioning

confidence: 99%

Section: Fabrication Of Microneedles Using 3d Printing Technologiesmentioning

confidence: 99%

See 3 more Smart Citations

3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery

et al. 2021

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Factors Affecting the Printability of Foods

2022

3D Printing of Foods

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Digital Light Processing of 2D Lattice Composites for Tunable Self‐Sensing and Mechanical Performance

et al. 2023

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This study investigates the mechanical and piezoresistive self‐sensing performance of additive manufacturing‐enabled 2D nanocomposite lattices under monotonic and cyclic tensile loading. Lattice structures comprising hexagonal, chiral, triangular, and reentrant unit cell topologies are realized via digital light processing using an acrylic photocurable resin filled with carbon nanotubes (CNTs). The results reveal that the piezoresistive sensitivity of reentrant and triangular lattices is nearly insensitive to changes in relative density. In contrast, the gauge factors of the hexagonal and chiral lattices rise by 300% and 500%, respectively, with an increase in relative density from 20 to 40%, which can be ascribed to their bend‐dominated behavior, causing an increase in surface strains in the lattice struts with increasing relative density for an imposed macroscopic strain. The measured stress versus strain responses compare well with nonlinear finite element results. Under strain‐controlled cyclic loading, the electrical resistance of the 2D lattices is found to decline over time due to reorientation of the CNTs in the surrounding viscoelastic polymer matrix. The findings provide valuable insights into the interrelations between sensing performance, cell architecture, and relative density of the lattices, and offer guidelines for the design of architected strain sensors and self‐sensing lightweight structures.

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Selective laser sintering 3D printing – an overview of the technology and pharmaceutical applications

Cited by 155 publications

References 60 publications

3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery

3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery

Factors Affecting the Printability of Foods

Digital Light Processing of 2D Lattice Composites for Tunable Self‐Sensing and Mechanical Performance

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